Cardiovascular risk in obesity: Different activation of inflammation and immune system between obese and morbidly obese subjects

European Journal of Internal Medicine

Volumn 22, Issue 4, 2011, Pages 418-423

  Graziani, Francesca ^a   Cialdella, Pio ^a   Liuzzo, Giovanna ^a   Basile, Eloisa ^a   Brugaletta, Salvatore ^a   Pedicino, Daniela ^a   Leccesi, Laura ^a   Guidone, Caterina ^a   Iaconelli, Amerigo ^a   Mingrone, Geltrude ^a   Biasucci, Luigi Marzio ^a   Crea, Filippo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

CD4 +CD28 null T lymphocytes; Immunity; Inflammation; Obesity

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; LEPTIN;

ADULT; ARTICLE; BLOOD VESSEL INJURY; BODY MASS; BODY WEIGHT; CARDIOVASCULAR RISK; CD4+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOASSAY; IMMUNONEPHELOMETRY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MALE; MORBID OBESITY; NULL CELL; RADIOIMMUNOASSAY; T LYMPHOCYTE SUBPOPULATION; WAIST CIRCUMFERENCE;

BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION; ITALY; MALE; MIDDLE AGED; MORBIDITY; OBESITY; OBESITY, MORBID; RADIOIMMUNOASSAY; RETROSPECTIVE STUDIES; RISK FACTORS; T-LYMPHOCYTES;

EID: 79960563741     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2011.04.010     Document Type: Article

References (46)

1. A. Lombardo, L.M. Biasucci, G.A. Lanza, S. Coli, P. Silvestri, and D. Cianflone Inflammation as a possible link between coronary and carotid plaque instability Circulation 109 2004 3158 3163
2. V. Fuster, J. Badimon, J.J. Badimon, and J.H. Chesebro The pathogenesis of coronary artery disease and acute coronary syndromes N Engl J Med 326 1992 310 318
3. L.M. Buja, and J.T. Willerson Role of inflammation in coronary plaque disruption Circulation 89 1992 503 505
4. P. Libby Molecular bases of the acute coronary syndromes Circulation 91 1995 2844 2850
5. A.C. Van der Wal, A.E. Becker, C.M. Van der Loos, and P.K. Das Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 90 1994 775 778
6. P. Libby, P.M. Ridker, and A. Maseri Inflammation and atherosclerosis Circulation 105 2002 1135 1143 (Pubitemid 34212626)
7. P. Libby, J.T. Willerson, and E. Braunwald C-reactive protein and coronary heart disease N Engl J Med 351 2004 295 298
8. G. Liuzzo, L.M. Biasucci, A.G. Rebuzzi, J.R. Gallimore, G. Caligiuri, and G.A. Lanza Plasma protein acute-phase response in unstable angina is not induced by ischemic injury Circulation 94 1996 2373 2380 (Pubitemid 26403561)
9. P.R. Moreno, E. Falk, I.F. Palacios, J.B. Newell, V. Fuster, and J.T. Fallon Macrophages infiltration an acute coronary syndromes: implications for plaque rupture Circulation 90 1994 775 778 (Pubitemid 24242744)
10. L.M. Biasucci, G. Liuzzo, S. Giubilato, R. Della Bona, M. Leo, and M. Pinnelli Delayed neutrophil apoptosis in patients with unstable angina: relation to C-reactive protein and recurrence of instability Eur Heart J 30 2009 2220 2225
11. G.G. Neri Serneri, D. Prisco, F. Martini, A.M. Gori, T. Brunelli, and L. Poggesi Acute T-cell activation is detectable in unstable angina Circulation 95 1997 1806 1812 (Pubitemid 27164397)
12. L. Jonasson, J. Holm, O. Skalli, G. Bondjers, and G.K. Hansson Regional accumulation of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque Arteriosclerosis 6 1986 131 138 (Pubitemid 16024121)
13. C.M. Weyand, J.J. Goronzy, G. Liuzzo, S.L. Kopecky, D.R. Holmes Jr., and R. Frye T-cell immunity in acute coronary syndromes Mayo Clin Proc 76 2001 1011 1020 (Pubitemid 32946013)
14. A.N. Vallejo, M. Schirmer, C.M. Weyand, and J.J. Goronzy Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways J Immunol 165 2000 6301 6307
15. D. Schmidt, J.J. Goronzy, and C.M. Weyand CD4+CD7-CD28+ T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity J Clin Invest 97 1996 2027 2037 (Pubitemid 26143956)
16. G. Liuzzo, S.L. Kopecky, R.L. Frye, W.M. O'Fallon, A. Maseri, and J.J. Goronzy Perturbation of the T-cell repertoire in patients with unstable angina Circulation 100 1999 2135 2139
17. G. Liuzzo, J.J. Goronzy, H. Yang, S.L. Kopecky, D.R. Holmes, and R.L. Frye Monoclonal T cell proliferation and plaque instability in acute coronary syndromes Circulation 201 2000 2883 2888 (Pubitemid 30415876)
18. G. Liuzzo, L.M. Biasucci, G. Trotta, S. Brugaletta, M. Pinnelli, and G. Digianuario Unusual CD4+CD28null T lymphocytes and recurrence of acute coronary events J Am Coll Cardiol 50 2007 1450 1458 (Pubitemid 47494592)
19. S.C. Smith, J.J. Allen, S.N. Blair, R.O. Bonow, L.M. Brass, and G.C. Fonarow AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute Circulation 113 2006 2363 2372 (Pubitemid 43947981)
20. P. Poirier, T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, and F.X. Pi-Sunyer Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism Circulation 113 2006 898 918
21. G.S. Hotamisligil Inflammation and metabolic disorder Nature 444 2006 860 867
22. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 2003 1796 1808 (Pubitemid 38063703)
23. H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, and C.J. Chou Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 2003 1821 1830 (Pubitemid 38063705)
24. C.A. Curat, A. Miranville, C. Sengenes, M. Diehl, C. Tonus, and R. Busse From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes Diabetes 53 2004 1285 1292 (Pubitemid 38569015)
25. A. Bouloumiè, L. Casteilla, and M. Lafontan Adipose tissue lymphocytes and macrophages in obesity and insulin resistance Arterioscler Thromb Vasc Biol 28 2008 1211 1213
26. U. Kintscher, M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, and M. Wabitsch T-lymphocyte infiltration in visceral adipose tissue. A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance Arterioscler Thromb Vasc Biol 28 2008 1304 1310
27. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 29 2006 S43 S48
28. National Cholesterol Education Program (NCEP) Expert Panel Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report Circulation 106 2002 3143 3421
29. A.V. Chobanian, G.L. Bakris, and H.R. Black The seventh report of the joint national committee on prevention, detection, evaluation and treatment of high blood pressure: the JNC7 report JAMA 19 2003 2560 2572 (Pubitemid 37430158)
30. A.N. Vallejo, J.C. Brandes, C.M. Weyand, and J.J. Goronzy Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence J Immunol 162 1999 6572 6579 (Pubitemid 29309380)
31. V. Rizzello, G. Liuzzo, S. Brugaletta, A. Rebuzzi, L.M. Biasucci, and F. Crea Modulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina Circulation 113 2006 2272 2277 (Pubitemid 43947972)
32. null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanism of incrased cardiovascular risk in diabetes mellitus Eur Heart J Jan. 8 2011 [Epub ahead of print]
33. P. Trayhurn, and I.S. Wood Adipokines: inflammation and the pleiotropic role of white adipose tissue Br J Nutr 92 2004 347 355 (Pubitemid 40277057)
34. J.P. Despres, and I. Lemieux Abdominal obesity and metabolic syndrome Nature 444 2006 881 887 (Pubitemid 46024995)
35. M. Karmazyn, D.M. Purdham, V. Rajapurohitam, and A. Zeidan Signalling mechanism underlying the metabolic and other effects of adipokines on the heart Cardiovasc Res 79 2008 279 286 (Pubitemid 351951616)
36. P.J. Havel Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis Exp Biol Med 226 2001 963 977
37. C.J. Hukshorn, F.M. van Dielen, W.A. Buurman, M.S. Westerterp-Plantenga, L.A. Campfield, and W.H. Saris The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects Int J Obes Relat Metab Disord 26 2002 504 509 (Pubitemid 34407263)
38. M. Halle, and P.B. Persson Role of leptin and leptin receptor in inflammation Am J Physiol Regul Integr Comp Physiol 284 2003 760 762
39. S. Loffreda, S.Q. Yang, H.Z. Lin, C.L. Karp, M.L. Brengman, and D.J. Wang Leptin regulates proinflammatory immune responses FASEB J 12 1998 57 65 (Pubitemid 28060271)
40. C. Bjørbaek Central leptin receptor action and resistance in obesity J Investig Med 57 2009 789 794
41. D.C. Lau, B. Dhillon, H. Yan, P.E. Szmitko, and S. Verma Adipokines: molecular links between obesity and atherosclerosis Am J Physiol Heart Circ Physiol 288 2005 2031 2041
42. T. Ronti, G. Lupattelli, and E. Mannarino The endocrine function of adipose tissue: an update Clin Endocrinol 64 2006 355 365
43. A.H. Berg, and P.E. Scherer Adipose tissue, inflammation, and cardiovascular disease Circ Res 96 2005 939 949 (Pubitemid 40712793)
44. L.M. Biasucci, F. Graziani, G. Liuzzo, P. Cialdella, E. Basile, and S. Brugaletta Cardiovascular risk in obesity: different activation of inflammation and immune system between obese and morbidly obese subjects. Abstract P5478, ESC Congress 2010; 28 Aug 2010-01 Sep 2010, Stockholm-Sweden Eur Heart J 31 2010 1004 [Abstract Supplement]
45. L.M. Biasucci, F. Graziani, V. Rizzello, G. Liuzzo, C. Guidone, and A.R. De Caterina Paradoxycal preservation of vascolar function in morbid obesity Am J Med 123 2010 727 734
46. F. Graziani, L.M. Biasucci, P. Cialdella, G. Liuzzo, S. Giubilato, and R. Della Bona Reduced thromboxane production in morbidly obese subjects Am J Cardiol Mar. 23 2011 [Epub ahead of print]