Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice

Pediatric Allergy and Immunology

Volumn 22, Issue 5, 2011, Pages 497-504

  Weise, Christin ^a   Heunemann, Carolin ^a   Loddenkemper, Christoph ^a   Herz, Udo ^b   van Tol, Eric A F ^b   Worm, Margitta ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Mead Johnson Nutritionals   (United States)

Author keywords

Arachidonic acid; Atopic eczema; Docosahexaenoic acid; Keratinocytes; Regulatory T cells

Indexed keywords

ALLERGEN; ARACHIDONIC ACID; ARASCO; DOCOSAHEXAENOIC ACID; INTERLEUKIN 10; INTERLEUKIN 4; KI 67 ANTIGEN; OVALBUMIN; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE SEVERITY; DRUG TOLERABILITY; FEMALE; IMMUNOHISTOLOGY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY; SKIN DEFECT; SKIN INFLAMMATION;

ALLERGENS; ANIMALS; ARACHIDONIC ACID; CELL LINE; DERMATITIS, ATOPIC; DIET THERAPY; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DRUG THERAPY, COMBINATION; FEMALE; KERATINOCYTES; MICE; MICE, INBRED BALB C; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY; TREATMENT OUTCOME;

EID: 79960562675     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2010.01133.x     Document Type: Article

References (30)

1. Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Allergy 2006: 61: 969-87.
2. Spector AA. Essentiality of fatty acids. Lipids 1999: 34 (Suppl): S1-3.
3. Stables MJ, Gilroy DW. Old and new generation lipid mediators in acute inflammation and resolution. Prog Lipid Res 2010: 50: 35-57. Jul 23.
4. Sala-Vila A, Miles EA, Calder PC. Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined. Clin Exp Allergy 2008: 38: 1432-50.
5. Chapkin RS, Kim W, Lupton JR, McMurray DN. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot Essent Fatty Acids 2009: 81: 187-91.
6. Kim W, Khan NA, McMurray DN, Prior IA, Wang N, Chapkin RS. Regulatory activity of polyunsaturated fatty acids in T-cell signaling. Prog Lipid Res 2010: 49: 250-61.
7. Mohrenschlager M, Darsow U, Schnopp C, Ring J. Atopic eczema: what's new? J Eur Acad Dermatol Venereol 2006: 20: 503-11. 13; quiz 12.
8. Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007: 85: 1457-64.
9. Field CJ, Clandini MT, Aerde JV. Polyunsaturated fatty acids and T-cell function: implications for the neonate. Lipids 2001: 36: 1025-32.
10. Werfel T. The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol 2009: 129: 1878-91.
11. Dahten A, Koch C, Ernst D, Schnoller C, Hartmann S, Worm M. Systemic PPARgamma Ligation Inhibits Allergic Immune Response in the Skin. J Invest Dermatol 2008: 128: 2211-8.
12. Rühl R, Koch C, Marosvolgyi T, et al. Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution. Br J Nutr 2008: 99: 1239-46.
13. Beissert S, Schwarz A, Schwarz T. Regulatory T cells. J Invest Dermatol 2006: 126: 15-24.
14. Liu YJ. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol 2007: 120: 238-44. quiz 45-6.
15. Decsi T, Koletzko B. Growth, fatty acid composition of plasma lipid classes, and plasma retinol and alpha-tocopherol concentrations in full-term infants fed formula enriched with omega-6 and omega-3 long-chain polyunsaturated fatty acids. Acta Paediatr 1995: 84: 725-32.
16. Field CJ, Thomson CA, Van Aerde JE, et al. Lower proportion of CD45R0+ cells and deficient interleukin-10 production by formula-fed infants, compared with human-fed, is corrected with supplementation of long-chain polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 2000: 31: 291-9.
17. Ziboh VA. Implications of dietary oils and polyunsaturated fatty acids in the management of cutaneous disorders. Arch Dermatol 1989: 125: 241-5.
18. Wright S. Essential fatty acids and the skin. Br J Dermatol 1991: 125: 503-15.
19. Nagelkerken L, Verzaal P, Lagerweij T, et al. Development of atopic dermatitis in mice transgenic for human apolipoprotein C1. J Invest Dermatol 2008: 128: 1165-72.
20. Mayser P, Mayer K, Mahloudjian M, et al. A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis. JPEN J Parenter Enteral Nutr 2002: 26: 151-8.
21. Broughton KS, Wade JW. Total fat and (n-3):(n-6) fat ratios influence eicosanoid production in mice. J Nutr 2002: 132: 88-94.
22. Hoffman D, Ziegler E, Mitmesser SH, Harris CL, Diersen-Schade DA. Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. Lipids 2008: 43: 29-35.
23. Schwab JM, Serhan CN. Lipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol 2006: 6: 414-20.
24. Serhan CN, Hong S, Gronert K, et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 2002: 21: 196.
25. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol 2005: 6: 1191-7.
26. Storey A, McArdle F, Friedmann PS, Jackson MJ, Rhodes LE. Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. J Invest Dermatol 2005: 124: 248-55.
27. Sapuntsova SG, Mel'nikova NP, Deigin VI, Kozulin EA, Timoshin SS. Proliferative processes in the epidermis of patients with atopic dermatitis treated with thymo-depressin. Bull Exp Biol Med 2002: 133: 488-90.
28. Goldstein JT, Dobrzyn A, Clagett-Dame M, Pike JW, DeLuca HF. Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor. Arch Biochem Biophys 2003: 420: 185-93.
29. Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008: 9: 310-8.
30. Stulnig TM. Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int Arch Allergy Immunol 2003: 132: 310-21.