Systemic PPARγ ligation inhibits allergic immune response in the skin

Journal of Investigative Dermatology

Volumn 128, Issue 9, 2008, Pages 2211-2218

  Dahten, Anja ^a   Koch, Christin ^a   Ernst, Dennis ^a   Schnöller, Corinna ^b   Hartmann, Susanne ^b   Worm, Margitta ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CIGLITAZONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; OVALBUMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; IMMUNOGLOBULIN G; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG INHIBITION; FEMALE; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; SENSITIZATION; SKIN ALLERGY; SKIN DEFECT; SKINFOLD THICKNESS; ANIMAL; ATOPIC DERMATITIS; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; PATHOLOGY; SKIN;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; FEMALE; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LIGANDS; MAST CELLS; MICE; MICE, INBRED BALB C; OVALBUMIN; PPAR GAMMA; SKIN; THIAZOLIDINEDIONES;

EID: 49549092038     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.84     Document Type: Article

References (49)

1. Akdis M, Simon HU, Weigl L, Kreyden O, Blaser K, Akdis CA (1999) Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol 163:466-75
2. Allam JP, Novak N (2006) The pathophysiology of atopic eczema. Clin Exp Dermatol 31:89-93
3. Bikle DD, Tu CL, Xie Z, Oda Y (2003) Vitamin D regulated keratinocyte differentiation: role of coactivators. J Cell Biochem 88:290-5
4. Boguniewicz M, Schmid-Grendelmeier P, Leung DY (2006) Atopic dermatitis. J Allergy Clin Immunol 118:40-3
5. Chen L, Martinez O, Overbergh L, Mathieu C, Prabhakar BS, Chan LS (2004) Early upregulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin Exp Immunol 138:375-87
6. Coffman RL (1993) Mechanisms of helper T-cell regulation of B-cell activity. Ann N Y Acad Sci 681:25-8
7. Dahten A, Mergemeier S, Worm M (2007) PPARgamma expression profile and its cytokine driven regulation in atopic dermatitis. Allergy 62:926-33
8. Demerjian M, Man MQ, Choi EH, Brown BE, Crumrine D, Chang S et al. (2006) Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. Exp Dermatol 15:154-60
9. Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC et al. (2000) Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-16
10. Flohr C, Johansson SG, Wahlgren CF, Williams H (2004) How atopic is atopic dermatitis? J Allergy Clin Immunol 114:150-8
11. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-12
12. Geha RS, Jabara HH, Brodeur SR (2003) The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol 3:721-32
13. Greene ME, Pitts J, McCarville MA, Wang XS, Newport JA, Edelstein C et al. (2000) PPARgamma: observations in the hematopoietic system. Prostaglandins Other Lipid Mediat 62:45-73
14. Gutermuth J, Ollert M, Ring J, Behrendt H, Jakob T (2004) Mouse models of atopic eczema critically evaluated. Int Arch Allergy Immunol 135:262-76
15. Hahn C, Teufel M, Herz U, Renz H, Erb KJ, Wohlleben G et al. (2003) Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. J Allergy Clin Immunol 111:1361-9
16. Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Dermatol Venerol 92:44-7
17. Hennino A, Vocanson M, Toussaint Y, Rodet K, Benetiere J, Schmitt AM et al. (2007) Skin-infiltrating CD8+ T cells initiate atopic dermatitis lesions. J Immunol 178:5571-7
18. Leung DY, Bieber T (2003) Atopic dermatitis. Lancet 361:151-60
19. Leung DY, Hirsch RL, Schneider L, Moody C, Takaoka R, Li SH et al. (1990) Thymopentin therapy reduces the clinical severity of atopic dermatitis. J Allergy Clin Immunol 85:927-33
20. Lewkowich IP, Rempel JD, HayGlass KT (2004) Antigen-specific versus total immunoglobulin synthesis: total IgE and IgG1, but not IgG2a levels predict murine antigen-specific responses. Int Arch Allergy Immunol 133:145-53
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-8
22. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J et al. (1997) Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 9:461-6
23. Mueller C, Weaver V, Vanden Heuvel JP, August A, Cantorna MT (2003) Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys 418:186-96
24. Natarajan C, Muthian G, Barak Y, Evans RM, Bright JJ (2003) Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J Immunol 171:5743-50
25. Nelde A, Teufel M, Hahn C, Duschl A, Sebald W, Brocker EB et al. (2001) The impact of the route and frequency of antigen exposure on the IgE response in allergy. Int Arch Allergy Immunol 124:461-9
26. Nencioni A, Grunebach F, Zobywlaski A, Denzlinger C, Brugger W, Brossart P (2002) Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. J Immunol 169:1228-35
27. Nie M, Corbett L, Knox AJ, Pang L (2005) Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. J Biol Chem 280:2550-61
28. Novak N, Bieber T (2003) Allergic and nonallergic forms of atopic diseases. J Allergy Clin Immunol 112:252-62
29. Ohmen JD, Hanifin JM, Nickoloff BJ, Rea TH, Wyzykowski R, Kim J et al. (1995) Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. J Immunol 154:1956-63
30. Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S (1998) Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-21
31. Ruhl R, Dahten A, Schweigert FJ, Herz U, Worm M (2003) Inhibition of IgE-production by peroxisome proliferator-activated receptor ligands. J Invest Dermatol 121:757-64
32. Savinko T, Lauerma A, Lehtimaki S, Gombert M, Majuri ML, Fyhrquist-Vanni N et al. (2005) Topical superantigen exposure induces epidermal accumulation of CD8+ T cells, a mixed Th1/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis. J Immunol 175:8320-6
33. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S et al. (2004) Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-83
34. Simon D, Vassina E, Yousefi S, Kozlowski E, Braathen LR, Simon HU (2004) Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment. J Allergy Clin Immunol 114:887-95
35. Spergel JM, Mizoguchi E, Brewer JP, Martin TR, Bhan AK, Geha RS (1998) Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 101:1614-22
36. Spergel JM, Mizoguchi E, Oettgen H, Bhan AK, Geha RS (1999) Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103:1103-11
37. Spergel JM, Paller AS (2003) Atopic dermatitis and the atopic march. J Allergy Clin Immunol 112:S118-27
38. Straus DS, Glass CK (2007) Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 28:551-8
39. Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA et al. (1999) A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 104:383-9
40. Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, Heim M et al. (2001) Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 15:3263-77
41. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241-52
42. Trifilieff A, Bench A, Hanley M, Bayley D, Campbell E, Whittaker P (2003) PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol 139:163-71
43. Venkatraman MS, Chittiboyina A, Meingassner J, Ho CI, Varani J, Ellis CN et al. (2004) Alpha-lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases. Arch Dermatol Res 296:97-104
44. Vollberg TM Sr, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM (1992) Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. Mol Endocrinol 6:667-76
45. Wang G, Savinko T, Wolff H, Dieu-Nosjean MC, Kemeny L, Homey B et al. (2007) Repeated epicutaneous exposures to ovalbumin progressively induce atopic dermatitis-like skin lesions in mice. Clin Exp Allergy 37:151-61
46. Wang LF, Lin JY, Hsieh KH, Lin RH (1996) Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J Immunol 156:4077-82
47. Woerly G, Honda K, Loyens M, Papin JP, Auwerx J, Staels B et al. (2003) Peroxisome proliferator-activated receptors alpha and gamma downregulate allergic inflammation and eosinophil activation. J Exp Med 198:411-21
48. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C et al. (2002) Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 118:11-6
49. Zingarelli B, Cook JA (2005) Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock 23:393-9