Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4445-4453

  Hocková, Dana ^a   Holý, Antonín ^a   Andrei, Graciela ^b   Snoeck, Robert ^b   Balzarini, Jan ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside phosphonates; Antiviral activity; Drug design; Purines; Pyrimidines

Indexed keywords

9 [2 (1 PHOSPHONOALKAN 2 YLOXY)ETHYL]ADENINE; 9 [2 (1 PHOSPHONOALKAN 2 YLOXY)ETHYL]ADENINE DERIVATIVE; 9 [2 (1 PHOSPHONOBUTAN 2 YLOXY)ETHYL]ADENINE; 9 [2 (1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]DIAMINOPURINE; 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]ADENINE; 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]GUANINE; 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]HYPOXANTHINE; 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]ADENINE; 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]GUANINE; 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]HYPOXANTHINE; 9 [2 (3 PHENYL 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]ADENINE; ACYCLIC NUCLEOSIDE; DIETHYL 1 [2 (1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]CYTOSINE; DIETHYL 1 [2 (1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]THYMINE; DIETHYL 1 [2 (1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]URACIL; DIETHYL 1 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]THYMINE; DIETHYL 3 (BENZYLOXY) 2 (2 HYDROXYETHOXY)PROPYLPHOSPHONATE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL] 2 AMINO 6 CHLOROPURINE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL] 6 CHLOROPURINE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]ADENINE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]GUANINE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]HYPOXANTHINE; DIETHYL 9 [2 (3 BENZYLOXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]URACIL; DIETHYL 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]GUANINE; DIETHYL 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]HYPOXANTHINE; DIETHYL 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]THYMINE; DIETHYL 9 [2 (3 HYDROXY 1 PHOSPHONOPROPAN 2 YLOXY)ETHYL]URACIL; NUCLEIC ACID BASE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOMEGALOVIRUS; DEBENZYLATION; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN IMMUNODEFICIENCY VIRUS; MITSUNOBU REACTION; NONHUMAN; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VACCINIA VIRUS; VARICELLA ZOSTER VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; HERPES SIMPLEX; HIV; HIV INFECTIONS; HUMANS; MICE; NUCLEOSIDES; PHOSPHONIC ACIDS; SIMPLEXVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VACCINIA; VACCINIA VIRUS; VIRUS DISEASES; VIRUSES;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 3; VACCINIA VIRUS;

EID: 79960561753     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.045     Document Type: Article

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