Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4601-4607

  Ma, Xiao Dong ^a   Zhang, Xuan ^b,c   Dai, Hui Fang ^a   Yang, Shi Qiong ^a   Yang, Liu Meng ^b   Gu, Shuang Xi ^a   Zheng, Yong Tang ^b   He, Qiu Qin ^a   Chen, Fen Er ^a  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Benzophenone derivatives; HIV; Naphthyl; NNRTIs; SAR

Indexed keywords

BENZOPHENONE DERIVATIVE; DELAVIRDINE; EFAVIRENZ; GW 678248; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 (1 BENZOYL 2 NAPHENOXY)ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 (6 BROMO 1 BENZOYL 2 NAPHENOXY)ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (2,4 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (2,5 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3 CHLORO 5 BROMOBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3 CHLORO 5 CYANOBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3 CHLOROBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3 METHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3,4 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [1 (3,5 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (2,4 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (2,5 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3 CHLORO 5 BROMOBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3 CHLOROBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3 FLUOROBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3 METHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3,4 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 BROMO 1 (3,5 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 CYANO 1 (3 CHLOROBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 CYANO 1 (3 METHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 CYANO 1 (3,4 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; N [4 (AMINOSULFONYL) 2 METHYLPHENYL] 2 [6 CYANO 1 (3,5 DIMETHYLBENZOYL) 2 NAPHENOXY]ACETAMIDE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS STRAIN;

ANTI-HIV AGENTS; BENZOPHENONES; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79960555807     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.007     Document Type: Article

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