A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia

BMC Gastroenterology

Volumn 11, Issue , 2011, Pages

  Thiel, Karolin ^a   Schenk, Martin ^a   Etspüler, Alexander ^a   Schenk, Thomas ^a   Morgalla, Matthias H ^a   Königsrainer, Alfred ^a   Thiel, Christian ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; CREATININE; ENDOTOXIN; LACTIC ACID; LACTIC ACID DERIVATIVE;

ACUTE LIVER FAILURE; AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; INDUCED HYPOTHERMIA; LACTATE BLOOD LEVEL; LIVER ASSIST DEVICE; LIVER RESECTION; MEDICAL INSTRUMENTATION; NONHUMAN; SEPSIS; SURVIVAL TIME; ANIMAL; BLOOD; EXTRACORPOREAL CIRCULATION; RANDOMIZATION; SWINE;

AMMONIA; ANIMALS; BODY TEMPERATURE; CREATININE; EXTRACORPOREAL CIRCULATION; FEMALE; HEPATECTOMY; HYPOTHERMIA, INDUCED; LACTATES; LIVER FAILURE, ACUTE; MODELS, ANIMAL; RANDOM ALLOCATION; SWINE;

EID: 79960555655     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-11-79     Document Type: Article

References (29)

1. Jalan R. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis 2003, 23:271-282.
2. Auzinger G, Wendon J. Intensive care management of acute liver failure. Curr Opin Crit Care 2008, 14:179-188. 10.1097/MCC.0b013e3282f6a450, 18388681.
3. Polson J, Lee WM. AASLD position paper: the management of acute liver failure. Hepatology 2005, 41:1179-1197. 10.1002/hep.20703, 15841455.
4. Sen S, Rose C, Ytrebo LM, Davies NA, Nedredal GI, Drevland SS, Kjonno M, Prinzen FW, Hodges SJ, Deutz NE, Williams R, Butterworth RF, Revhaug A, Jalan R. Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Crit Care Med 2006, 34:158-164. 10.1097/01.CCM.0000196203.39832.3C, 16374170.
5. Ytrebo LM, Sen S, Rose C, Davies NA, Nedredal GI, Fuskevaag OM, Ten Have GA, Prinzen FW, Williams R, Deutz NE, Jalan R, Revhaug A. Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis. Scand J Gastroenterol 2006, 41:1350-1360. 10.1080/00365520600714527, 17060130.
6. Hochleitner B, Hengster P, Bucher H, Ladurner R, Schneeberger S, Krismer A, Kleinsasser A, Barnas U, Klima G, Margreiter R. Significant survival prolongation in pigs with fulminant hepatic failure treated with a novel microgravity-based bioartificial liver. Artif Organs 2006, 30:906-914. 10.1111/j.1525-1594.2006.00323.x, 17181831.
7. Ytrebo LM, Nedredal GI, Langbakk B, Revhaug A. An experimental large animal model for the assessment of bioartificial liver support systems in fulminant hepatic failure. Scand J Gastroenterol 2002, 37:1077-1088. 10.1080/003655202320378293, 12378705.
8. Ryska M, Kieslichova E, Pantoflicek T, Ryska O, Zazula R, Skibova J, Hajek M. Devascularization surgical model of acute liver failure in minipigs. Eur Surg Res 2004, 36:179-184. 10.1159/000077261, 15178908.
9. Benoist S, Sarkis R, Baudrimont M, Delelo R, Robert A, Vaubourdolle M, Balladur P, Calmus Y, Capeau J, Nordlinger B. A reversible model of acute hepatic failure by temporary hepatic ischemia in the pig. J Surg Res 2000, 88:63-69. 10.1006/jsre.1999.5778, 10644469.
10. Ladurner R, Hochleitner B, Schneeberger S, Barnas U, Krismer A, Kleinsasser A, Offner F, Konigsrainer I, Margreiter R, Konigsrainer A. Extended liver resection and hepatic ischemia in pigs: a new, potentially reversible model to induce acute liver failure and study artificial liver support systems. Eur Surg Res 2005, 37:365-369. 10.1159/000090338, 16465062.
11. Knubben K, Thiel C, Schenk M, Etspuler A, Schenk T, Morgalla MH, Konigsrainer A. A new surgical model for hepatectomy in pigs. Eur Surg Res 2008, 40:41-46.
12. Thiel C, Thiel K, Etspueler A, Morgalla MH, Rubitschek S, Schmid S, Steurer W, Konigsrainer A, Schenk M. A Reproducible Porcine Model of Acute Liver Failure Induced by Intrajejunal Acetaminophen Administration. Eur Surg Res 2011, 46:118-126. 10.1159/000323411, 21252557.
13. Takada Y, Ishiguro S, Fukunaga K. Large-animal models of fulminant hepatic failure. J Artif Organs 2003, 6:9-13. 10.1007/s100470300001, 14598118.
14. Ho DW, Lam DK, Chen YB, To J, Ng IO, Fan ST. Galactosamine-induced fulminant liver failure--observation in a porcine model. Asian J Surg 2002, 25:73-79.
15. Fruhauf NR, Oldhafer KJ, Holtje M, Kaiser GM, Fruhauf JH, Stavrou GA, Bader A, Broelsch CE. A bioartificial liver support system using primary hepatocytes: a preclinical study in a new porcine hepatectomy model. Surgery 2004, 136:47-56. 10.1016/j.surg.2003.12.017, 15232539.
16. Tunon MJ, Alvarez M, Culebras JM, Gonzalez-Gallego J. An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol 2009, 15:3086-3098. 10.3748/wjg.15.3086, 2705730, 19575487.
17. Ambrosino G, Varotto S, Stefano Basso SM, Galavotri D, Cecchetto A, Carraro P, Naso A, De Silvestro G, Plebani M, Giron G, Abatangelo G, Donato D, Cestrone A, Marrelli L, Trombetta M, Lorenzelli V, Picardi A, Colantoni A, Van Thiel D, Ricordi C, D'Amico FD. Development of a new bioartificial liver using a porcine autologous biomatrix as hepatocyte support. ASAIO J 2002, 48:592-597. 10.1097/00002480-200211000-00004, 12455768.
18. Thiel C, Thiel K, Etspueler A, Schenk T, Morgalla MH, Koenigsrainer A, Schenk M. Standardized intensive care unit management in an anhepatic pig model: new standards for analyzing liver support systems. Crit Care 2010, 14:R138. 10.1186/cc9196, 2945114, 20649958.
19. Polderman KH. Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet 2008, 371:1955-1969. 10.1016/S0140-6736(08)60837-5, 18539227.
20. Schreckinger M, Marion DW. Contemporary Management of Traumatic Intracranial Hypertension: Is There a Role for Therapeutic Hypothermia?. Neurocrit Care 2009,
21. Jalan R, Davies NA, Olde Damink SW. Hypothermia for the management of intracranial hypertension in acute liver failure. Metab Brain Dis 2002, 17:437-444. 10.1023/A:1021930506853, 12602519.
22. Arkadopoulos N, Kostopanagiotou G, Nastos C, Papalois A, Papoutsidakis N, Kalimeris K, Defterevos G, Kanna T, Polyzois K, Kampouroglou G, Kypriotis D, Costopanagiotou C, Pafiti A, Tzanatos H, Smyrniotis V. Reversal of experimental posthepatectomy liver failure in pigs: a new application of hepatocyte bioreactors. Artif Organs 2011, 35:29-36. 10.1111/j.1525-1594.2010.01016.x, 20618230.
23. Ryska M, Laszikova E, Pantoflicek T, Ryska O, Prazak J, Koblihova E. Fractionated plasma separation and adsorption significantly decreases intracranial pressure in acute liver failure: experimental study. Eur Surg Res 2009, 42:230-235. 10.1159/000208790, 19279388.
24. Desille M, Fremond B, Mahler S, Malledant Y, Seguin P, Bouix A, Lebreton Y, Desbois J, Campion JP, Clement B. Improvement of the neurological status of pigs with acute liver failure by hepatocytes immobilized in alginate gel beads inoculated in an extracorporeal bioartificial liver. Transplant Proc 2001, 33:1932-1934. 10.1016/S0041-1345(00)02718-4, 11267577.
25. Ho DW, Fan ST, To J, Woo YH, Zhang Z, Lau C, Wong J. Selective plasma filtration for treatment of fulminant hepatic failure induced by D-galactosamine in a pig model. Gut 2002, 50:869-876. 10.1136/gut.50.6.869, 1773226, 12010892.
26. Dmello D, Cruz-Flores S, Matuschak GM. Moderate hypothermia with intracranial pressure monitoring as a therapeutic paradigm for the management of acute liver failure: a systematic review. Intensive Care Med 2010, 36:210-213. 10.1007/s00134-009-1702-2, 19847396.
27. Rozga J, Morsiani E, Levchenko N, Fujioka H, Demetriou AA. Anhepatic pig:evaluation of a model [abstract]. J Hepatol 1993, 18:S72.
28. Vaquero J, Rose C, Butterworth RF. Keeping cool in acute liver failure: rationale for the use of mild hypothermia. J Hepatol 2005, 43:1067-1077. 10.1016/j.jhep.2005.05.039, 16246452.
29. Stravitz RT, Larsen FS. Therapeutic hypothermia for acute liver failure. Crit Care Med 2009, 37:S258-S264. 10.1097/CCM.0b013e3181aa5fb8, 19535956.