Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change

Acta Biochimica et Biophysica Sinica

Volumn 40, Issue 4, 2008, Pages 339-348

  Yang, Ling ^a   Liu, Xiaoyu ^a   Hao, Jinyu ^a   Yang, Yunlong ^a   Zhao, Mingxia ^a   Zuo, Ji ^a   Liu, Wen ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Bax conformational change; Cytochrome c release; Glucose deprivation; Glucose regulated protein 75

Indexed keywords

BAX PROTEIN, RAT; CYTOCHROME C; GLUCOSE; GLUCOSE REGULATED PROTEINS; GLUCOSE-REGULATED PROTEINS; HEAT SHOCK PROTEIN 70; MEMBRANE PROTEIN; PROTEIN BAX;

ANIMAL; APOPTOSIS; ARTICLE; CELL STRAIN; CHEMISTRY; METABOLISM; PROTEIN CONFORMATION; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CYTOCHROMES C; GLUCOSE; HSP70 HEAT-SHOCK PROTEINS; MEMBRANE PROTEINS; PC12 CELLS; PROTEIN CONFORMATION; RATS;

EID: 42449116100     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2008.00409.x     Document Type: Article

References (34)

1. Gupta S. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci 2001, 69 : 2957 2964.
2. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004, 116 : 205 219.
3. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305 : 626 629.
4. Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003, 22 : 8590 8607.
5. Wall NR, Mohammad RM, Al-Katib AM. Bax: Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh. Leuk Res 1999, 23 : 881 888.
6. Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ et al. Loss of Bif-1 suppresses Bax-Bak conformational change and mitochondrial apoptosis. Mol Cell Biol 2005, 25 : 9369 9382.
7. Young JC, Agashe VR, Siegers K, Hartl FU. Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol 2004, 5 : 781 791.
8. Wadhwa R, Kaul SC, Ikawa Y, Sugimoto Y. Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype. J Biol Chem 1993, 268 : 6615 6621.
9. Ran Q, Wadhwa R, Kawai R, Kaul SC, Sifers RN, Bick RJ, Smith JR et al. Extramitochondrial localization of mortalin-mthsp70-PBP74-GRP75. Biochem Biophys Res Commun 2000, 275 : 174 179.
10. Wadhwa R, Taira K, Kaul SC. An Hsp70 family chaperone, mortalin-mthsp70-PBP74-Grp75: what, when, and where Cell Stress Chap-erones 2002, 7 : 309 316.
11. Liu Y, Liu W, Song XD, Zuo J. Effect of GRP75-mthsp70-PBP74-mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells. Mol Cell Biochem 2005, 268 : 45 51.
12. Zheng DH, Zuo J, Yang ZJ, Xia BL, Zhang XN. Grp75 protects cells from injuries caused by glucose deprivation. Yi Chuan Xue Bao 2000, 27 : 666 671.
13. -ΔΔCT) method. Methods 2001, 25 : 402 408.
14. Aubry JP, Blaecke A, Lecoanet-Henchoz S, Jeannin P, Herbault N, Caron G, Moine V et al. Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 1999, 37 : 197 204.
15. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001, 292 : 624 626.
16. Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA 1997, 94 : 3668 3672.
17. Wadhwa R, Pereira-Smith OM, Reddel RR, Sugimoto Y, Mitsui Y, Kaul SC. Correlation between complementation group for immortality and the cellular distribution of mortalin. Exp Cell Res 1995, 216 : 101 106.
18. Kaula SC, Reddelb RR, Sugiharac T, Mitsuia Y, Wadhwac R. Inacti-vation of p53 and life span extension of human diploid fibroblasts by mot-2. FEBS Lett 2000, 474 : 159 164.
19. Xu J, Xiao HH, Sartorelli AC. Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70. Oncol Res 1999, 11 : 429 435.
20. Mizukoshi E, Suzuki M, Loupatov A, Uruno T, Hayashi H, Misono T, Kaul SC et al. Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75-mortalin. Biochem J 1999, 343 : 461 466.
21. +]i ratio in cultured vascular smooth muscle cells. Circ Res 2002, 91 : 915 922.
22. Massa SM, Longo FM, Zuo J, Wang S, Chen J, Sharp FR. Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain. J Neurosci Res 1995, 40 : 807 819.
23. Reed JC, Green DR. Remodeling for demolition: Changes in mitochondrial ultrastructure during apoptosis. Mol Cell 2002, 9 : 1 3.
24. Kulms D, Schwarz T. Molecular mechanisms involved in UV-induced apoptotic cell death. Skin Pharmacol Appl Skin Physiol 2002, 15 : 342 347.
25. Goyeneche AA, Harmon JM, Telleria CM. Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis. Reproduction 2006, 131 : 103 111.
26. Farrow SN, Brown R. New members of the Bcl-2 family and their protein partners. Curr Opin Genet Dev 1996, 6 : 45 49.
27. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997, 275 : 1129 1132.
28. Zha H, Reed JC. Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells. J Biol Chem 1997, 272 : 31482 31488.
29. Schinzel A, Kaufmann T, Schuler M, Martinalbo J, Grubb D, Borner C. Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol 2004, 164 : 1021 1032.
30. Samali A, Cotter TG. Heat shock proteins increase resistance to apoptosis. Exp Cell Res 1996, 223 : 163 170.
31. McClellan AJ, Frydman J. Molecular chaperones and the art of recognizing a lost cause. Nat Cell Biol 2001, 3 : E51 E53.
32. Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002, 295 : 1852 1858.
33. Wadhwa R, Yaguchi T, Hasan MK, Mitsui Y, Reddel RR, Kaul SC. Hsp70 family member, mot-2-mthsp70-GRP75, binds to the cyto-plasmic sequestration domain of the p53 protein. Exp Cell Res 2002, 274 : 246 253.
34. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004, 303 : 1010 1014.