Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma

Histopathology

Volumn 59, Issue 1, 2011, Pages 90-97

  Okumura, Yoshihide ^a,b   Miyabe, Satoru ^a,b   Nakayama, Takahisa ^a,b   Fujiyoshi, Yukio ^a   Hattori, Hideo ^a   Shimozato, Kazuo ^b   Inagaki, Hiroshi ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

CRTC1 3 MAML2 fusions; Histological classification; Mucoepidermoid; Prognosis

Indexed keywords

CREB REGULATED TRANSCRIPTION COACTIVATOR 1; CREB REGULATED TRANSCRIPTION COACTIVATOR 3; HYBRID PROTEIN; NOTCH COACTIVATOR MASTERMIND LIKE GENE 2; ONCOPROTEIN; UNCLASSIFIED DRUG;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE FUSION; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR BIOLOGY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, MUCOEPIDERMOID; CHILD; DNA-BINDING PROTEINS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NUCLEAR PROTEINS; ONCOGENE FUSION; ONCOGENE PROTEINS, FUSION; PROGNOSIS; SALIVARY GLAND NEOPLASMS; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 79960467125     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03890.x     Document Type: Article

References (17)

1. Goode RK, El-Naggar AK. Mucoepidermoid carcinoma. In Barnes L, Eveson J, Reichart P, Sidransky D eds. Pathology and genetics of head and neck tumours. World Health Organization classification of tumours. Lyon: IARC Press, 2005; 219-220.
2. Tonon G, Modi S, Wu L et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat. Genet. 2003; 33; 208-213.
3. Enlund F, Behboudi A, Andren Y et al. Altered Notch signaling resulting from expression of a WAMTP1-2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp. Cell Res. 2004; 292; 21-28.
4. Coxon A, Rozenblum E, Park YS et al. MECT1-MAML2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res. 2005; 65; 7137-7144.
5. Wu L, Liu J, Gao P et al. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J. 2005; 24; 2391-2402.
6. Okabe M, Miyabe S, Nagatsuka H et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin. Cancer Res. 2006; 12; 3902-3907.
7. Behboudi A, Enlund F, Winnes M et al. Molecular classification of mucoepidermoid carcinomas - prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosom. Cancer 2006; 45; 470-481.
8. Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosom. Cancer 2007; 46; 708-715.
9. Miyabe S, Okabe M, Nagatsuka H et al. Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. J. Oral Maxillofac. Surg. 2009; 67; 1432-1441.
10. Fehr A, Röser K, Heidorn K, Hallas C, Löning T, Bullerdiek J. A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosom. Cancer 2008; 47; 203-206.
11. Nakayama T, Miyabe S, Okabe M et al. Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Mod. Pathol. 2009; 22; 1575-1581.
12. Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 1992; 69; 2021-2030.
13. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 1998; 82; 1217-1224.
14. Brandwein MS, Ivanov K, Wallace DI et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am. J. Surg. Pathol. 2001; 25; 835-845.
15. Ozawa H, Tomita T, Sakamoto K et al. Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn. J. Clin. Oncol. 2008; 38; 414-418.
16. Zhang H, Oliveira AM. Fusion genes in epithelial neoplasia. J. Clin. Pathol. 2010; 63; 4-11.
17. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. Reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am. J. Surg. Pathol. 2010; 34; 1106-1121.