Correlations between sadness-induced cerebral activations and schizophrenia symptoms: An fMRI study of sex differences

European Psychiatry

Volumn 26, Issue 5, 2011, Pages 320-326

  Mendrek, A ^a   Jimenez J A ^a   Mancini Marie A ^a   Fahim, C ^a   Stip, E ^a  

^a CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

Author keywords

Emotion processing; FMRI; Positive and negative symptoms; Schizophrenia; Sex differences

Indexed keywords

CHLORPROMAZINE; HALOPERIDOL; OLANZAPINE; QUETIAPINE; RISPERIDONE; ZUCLOPENTHIXOL;

ADULT; ANTERIOR CINGULATE; ARTICLE; ASSOCIATION; AUDIOVISUAL EQUIPMENT; BRAIN DEPTH STIMULATION; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DEPRESSION INVENTORY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; MALE; NEGATIVE SYNDROME; NEUROIMAGING; OCCIPITAL CORTEX; PARIETAL CORTEX; POSITIVE AND NEGATIVE SYNDROME SCALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; STIMULUS RESPONSE; TEMPORAL CORTEX;

ADULT; BRAIN MAPPING; CEREBRAL CORTEX; EMOTIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SCHIZOPHRENIA; SEX CHARACTERISTICS;

EID: 79960466634     PISSN: 09249338     EISSN: 17783585     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2010.04.007     Document Type: Article

References (46)

1. Andia A.M., et al. Gender differences in schizophrenia. J Nerv Ment Dis 1995, 183(8):522-528.
2. Beauregard M., Levesque J., Bourgouin P. Neural correlates of conscious self-regulation of emotion. J Neurosci 2001, 21(18):pRC165.
3. Das P., et al. Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophr Res 2007, 90(1-3):284-294.
4. Demaree H.A., et al. Brain lateralization of emotional processing: historical roots and a future incorporating " dominance" Behav Cogn Neurosci Rev 2005, 4(1):3-20.
5. Epstein J., Stern E., Silbersweig D. Mesolimbic activity associated with psychosis in schizophrenia. Symptom-specific PET studies. Ann N Y Acad Sci 1999, 877:562-574.
6. Eugene F., et al. The impact of individual differences on the neural circuitry underlying sadness. Neuroimage 2003, 19(2 Pt 1):354-364.
7. Fahim C., et al. Brain activity during emotionally negative pictures in schizophrenia with and without flat affect: an fMRI study. Psychiatry Res 2005, 140(1):1-15.
8. Grimm S., et al. Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry 2008, 63(4):369-376.
9. Gross J.J. Emotion regulation in adulthood: timing is everything. Curr Dir Psychol Sci 2001, 10(6):214-219.
10. Gross J.J. Handbook of Emotion Regulation 2007, Guilford Press, New York.
11. Gur R.C., et al. Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cereb Cortex 2002, 12(9):998-1003.
12. Karama S., et al. Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 2002, 16(1):1-13.
13. Kay S.R., Opler L.A., Fiszbein A. Significance of positive and negative syndromes in chronic schizophrenia. Br J Psychiatry 1986, 149:439-448.
14. Kohler C.G., et al. Facial emotion recognition in schizophrenia: intensity effects and error pattern. Am J Psychiatry 2003, 160(10):1768-1774.
15. Kosaka H., et al. Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophr Res 2002, 57(1):87-95.
16. Kring A.M., Neale J.M. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?. J Abnorm Psychol 1996, 105(2):249-257.
17. Lee T.M., et al. Neural activities associated with emotion recognition observed in men and women. Mol Psychiatry 2005, 10(5):450-455.
18. Leppänen J.M. Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 2006, 19(1):34-39.
19. Leung A., Chue P. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand Suppl 2000, 401:3-38.
20. Levesque J., et al. Neural circuitry underlying voluntary suppression of sadness. Biol Psychiatry 2003, 53(6):502-510.
21. Lewine R., Burbach D., Meltzer H.Y. Effect of diagnostic criteria on the ratio of male to female schizophrenic patients. Am J Psychiatry 1984, 141(1):84-87.
22. Mendrek A., et al. Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients. Aust N Z J Psychiatry 2007, 41(2):136-141.
23. Paradiso S., et al. Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography. Am J Psychiatry 2003, 160(10):1775-1783.
24. Phillips M.L., et al. A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Res 1999, 92(1):11-31.
25. Poline J.B., et al. Combining spatial extent and peak intensity to test for activations in functional imaging. Neuroimage 1997, 5(2):83-96.
26. Ring N., et al. Gender differences in the incidence of definite schizophrenia and atypical psychosis-focus on negative symptoms of schizophrenia. Acta Psychiatr Scand 1991, 84(6):489-496.
27. Sanjuan J., et al. Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations. Psychiatry Res 2007, 154(1):21-29.
28. Schneider F., et al. Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology. Schizophr Res 1995, 17(1):67-75.
29. Schneider F., et al. Differential amygdala activation in schizophrenia during sadness. Schizophr Res 1998, 34(3):133-142.
30. Schultz S.K., et al. The life course of schizophrenia: age and symptom dimensions. Schizophr Res 1997, 23(1):15-23.
31. Semkovska M., Bedard M.A., Stip E. Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives. Encephale 2001, 27(5):405-415.
32. Shtasel D.L., et al. Gender differences in the clinical expression of schizophrenia. Schizophr Res 1992, 7(3):225-231.
33. Stip E., et al. Neural correlates of sad feelings in schizophrenia with and without blunted affect. Can J Psychiatry 2005, 50(14):909-917.
34. Surguladze S., et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry 2005, 57(3):201-209.
35. Szymanski S., et al. Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. Am J Psychiatry 1995, 152(5):698-703.
36. Takahashi T., et al. Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders. A magnetic resonance imaging study. Eur Arch Psychiatry Clin Neurosci 2004, 254(5):273-280.
37. Taylor R., Langdon R. Understanding gender differences in schizophrenia: a review of the literature. Curr Psychiatry Rev 2006, 2:255-265.
38. Taylor S.F., et al. A functional anatomic study of emotion in schizophrenia. Schizophr Res 2002, 58(2-3):159-172.
39. Taylor S.F., et al. Neural response to emotional salience in schizophrenia. Neuropsychopharmacology 2005, 30(5):984-995.
40. Tzourio-Mazoyer N., et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002, 15(1):273-289.
41. Wager T.D., et al. Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging. Neuroimage 2003, 19(3):513-531.
42. Walters N.B., et al. In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation. Proc Natl Acad Sci U S A 2003, 100(5):2981-2986.
43. Weinberger D.R., Berman K.F. Prefrontal function in schizophrenia: confounds and controversies. Philos Trans R Soc Lond B Biol Sci 1996, 351(1346):1495-1503.
44. Williams L.M., et al. Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am J Psychiatry 2004, 161(3):480-489.
45. Williams L.M., et al. Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes. Psychiatry Res 2007, 155(1):29-44.
46. Woods S.W. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 2003, 64(6):663-667.