메뉴 건너뛰기




Volumn 52, Issue 8, 2011, Pages 1435-1445

Treatment of refractory or relapsed acquired aplastic anemia: Review of established and experimental approaches

Author keywords

alemtuzumab; Bone marrow failure; cyclosporine A; pancytopenia

Indexed keywords

ALEMTUZUMAB; ANDROGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DACLIZUMAB; DANAZOL; ELTROMBOPAG; ERYTHROPOIETIN; ETANERCEPT; FLUCONAZOLE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; MESNA; MYCOPHENOLIC ACID; NORFLOXACIN; PARACETAMOL; RAPAMYCIN; RECOMBINANT STEM CELL FACTOR; RITUXIMAB; STEM CELL FACTOR; SULFAMETHOXAZOLE; THYMOCYTE ANTIBODY; TRIMETHOPRIM; UNINDEXED DRUG; VALACICLOVIR; VASCULOTROPIN;

EID: 79960413981     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.568646     Document Type: Review
Times cited : (12)

References (90)
  • 1
    • 33750628439 scopus 로고    scopus 로고
    • Current concepts in the pathophysiology and treatment of aplastic anemia
    • Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 2006;108:2509-2519
    • (2006) Blood , vol.108 , pp. 2509-2519
    • Young, N.S.1    Calado, R.T.2    Scheinberg, P.3
  • 2
    • 30344440780 scopus 로고    scopus 로고
    • Evaluation of angiogenesis and vascular endothelial growth factor expression in the bone marrow of patients with aplastic anemia
    • Füreder W, Krauth MT, Sperr WR, et al. Evaluation of angiogenesis and vascular endothelial growth factor expression in the bone marrow of patients with aplastic anemia. Am J Pathol 2006; 168:123-130.
    • (2006) Am J Pathol , vol.168 , pp. 123-130
    • Füreder, W.K.1
  • 3
    • 77953042879 scopus 로고    scopus 로고
    • Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia
    • Chao YH, Peng CT, Harn HJ, Chan CK, Wu KH. Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia. Ann Hematol 2010;89:715-723
    • (2010) Ann Hematol , vol.89 , pp. 715-723
    • Chao, Y.H.1    Peng, C.T.2    Harn, H.J.3    Chan, C.K.4    Wu, K.H.5
  • 4
    • 64949094793 scopus 로고    scopus 로고
    • Bone marrow angiogenesis in aplastic anemia-a study of CD34 and VEGF expression in bone marrow biopsies
    • Gupta P, Khurana N, Singh T, Gupta D, Dhingra KK. Bone marrow angiogenesis in aplastic anemia-a study of CD34 and VEGF expression in bone marrow biopsies. Hematology 2009;14:16-21
    • (2009) Hematology , vol.14 , pp. 16-21
    • Gupta, P.1    Khurana, N.2    Singh, T.3    Gupta, D.4    Dhingra, K.K.5
  • 6
    • 4944249404 scopus 로고    scopus 로고
    • Diazepam-binding inhibitor-related protein 1: A candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells
    • DOI 10.1182/blood-2004-05-1839
    • Feng X, Chuhjo T, Sugimori C, et al. Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. Blood 2004;104:2425-2431 (Pubitemid 39331843)
    • (2004) Blood , vol.104 , Issue.8 , pp. 2425-2431
    • Feng, X.1    Chuhjo, T.2    Sugimori, C.3    Kotani, T.4    Lu, X.5    Takami, A.6    Takamatsu, H.7    Yamazaki, H.8    Nakao, S.9
  • 7
    • 33947206248 scopus 로고    scopus 로고
    • Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
    • DOI 10.1182/blood-2006-07-036715
    • Takamatsu H, Feng X, Chuhjo T, et al. Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia. Blood 2007;109:2514-2520 (Pubitemid 46425896)
    • (2007) Blood , vol.109 , Issue.6 , pp. 2514-2520
    • Takamatsu, H.1    Feng, X.2    Chuhjo, T.3    Lu, X.4    Sugimori, C.5    Okawa, K.6    Yamamoto, M.7    Iseki, S.8    Nakao, S.9
  • 8
    • 77953078209 scopus 로고    scopus 로고
    • Aplastic anemia: Pathophysiology and treatment
    • Young NS, Bacigalupo A, Marsh JCW. Aplastic anemia: pathophysiology and treatment. Biol Blood Marrow Transplant 2010;16(1 Suppl.):119-125
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.1 SUPPL. , pp. 119-125
    • Young, N.S.1    Bacigalupo, A.2    Jcw, M.3
  • 9
    • 70349213313 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of aplastic anaemia
    • Marsh JCW, Ball SE, Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol 2009;147:43-70
    • (2009) Br J Haematol , vol.147 , pp. 43-70
    • Jcw, M.1    Ball, S.E.2    Cavenagh, J.3
  • 10
    • 0037441586 scopus 로고    scopus 로고
    • Antithymocyte globulin with or without cyclosporin A: 11-Year follow-up of a randomized trial comparing treatments of aplastic anemia
    • DOI 10.1182/blood-2002-04-1134
    • Frickhofen N, Heimpel H, Kaltwasser JP, Schrezenmeier H. Antithymocyte globulin with or without cyclosporine A: 11- year follow up of a randomized trial comparing treatments of aplastic anemia. Blood 2003;101:1236-1242 (Pubitemid 36182490)
    • (2003) Blood , vol.101 , Issue.4 , pp. 1236-1242
    • Frickhofen, N.1    Heimpel, H.2    Kaltwasser, J.P.3    Schrezenmeier, H.4
  • 11
    • 0036566542 scopus 로고    scopus 로고
    • Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia
    • DOI 10.1182/blood.V99.9.3129
    • Maciejewski JP, Risitano A, Sloand EM, Nunez O, Young NS. Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia. Blood 2002;99:3129-3135 (Pubitemid 34525289)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3129-3135
    • Maciejewski, J.P.1    Risitano, A.2    Sloand, E.M.3    Nunez, O.4    Young, N.S.5
  • 12
    • 32644434385 scopus 로고    scopus 로고
    • - blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia
    • DOI 10.1182/blood-2005-06-2485
    • Sugimori C, Chuhjo T, Feng X, et al. Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Blood 2006;107:1308-1314 (Pubitemid 43242363)
    • (2006) Blood , vol.107 , Issue.4 , pp. 1308-1314
    • Sugimori, C.1    Chuhjo, T.2    Feng, X.3    Yamazaki, H.4    Takami, A.5    Teramura, M.6    Mizoguchi, H.7    Omine, M.8    Nakao, S.9
  • 13
    • 58149090759 scopus 로고    scopus 로고
    • Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia
    • Scheinberg P, Wu CO, Nunez O, Young NS. Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia. Br J Haematol 2009;144:206-216
    • (2009) Br J Haematol , vol.144 , pp. 206-216
    • Scheinberg, P.1    Wu, C.O.2    Nunez, O.3    Young, N.S.4
  • 14
    • 74049143812 scopus 로고    scopus 로고
    • Predictors of response to immunosuppressive therapy with antithymocyte globulin and cyclosporine and prognostic factors for survival in patients with severe aplastic anemia
    • Chang MH, Kim KH, Kim HS, et al. Predictors of response to immunosuppressive therapy with antithymocyte globulin and cyclosporine and prognostic factors for survival in patients with severe aplastic anemia. Eur J Haematol 2010;84:154-159
    • (2010) Eur J Haematol , vol.84 , pp. 154-159
    • Chang, M.H.1    Kim, K.H.2    Kim, H.S.3
  • 15
    • 67649562293 scopus 로고    scopus 로고
    • Is the early cyclosporine A level predictive of the outcome of immunosuppressive therapy in severe aplastic anemia?
    • Song MK, Chung JS, Joo YD, et al. Is the early cyclosporine A level predictive of the outcome of immunosuppressive therapy in severe aplastic anemia? Eur J Haematol 2009;83:72-78
    • (2009) Eur J Haematol , vol.83 , pp. 72-78
    • Song, M.K.1    Chung, J.S.2    Joo, Y.D.3
  • 16
    • 24744440150 scopus 로고    scopus 로고
    • Immunosuppressive therapy for aplastic anemia in children: A more severe disease predicts better survival
    • Führer M, Rampf U, Baumann I, et al. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood. 2005; 106: 2102-2104.
    • (2005) Blood , vol.106 , pp. 2102-2104
    • Führer, M.R.1
  • 17
    • 0033514487 scopus 로고    scopus 로고
    • Effectiveness of immunosuppressive therapy in older patients with aplastic anemia. European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party
    • Tichelli A, Socié G, Henry-Amar M, et al. Effectiveness of immunosuppressive therapy in older patients with aplastic anemia. European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party. Ann Intern Med 1999;130:193-201
    • (1999) Ann Intern Med , vol.130 , pp. 193-201
    • Tichelli, A.1    Socié, G.2    Henry-Amar, M.3
  • 21
  • 23
    • 62649106211 scopus 로고    scopus 로고
    • Diagnosis and treatment of acquired aplastic anemia
    • Bacigalupo A, Passweg J. Diagnosis and treatment of acquired aplastic anemia. Hematol Oncol Clin North Am 2009;23:159-170
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 159-170
    • Bacigalupo, A.1    Passweg, J.2
  • 24
    • 77955659229 scopus 로고    scopus 로고
    • Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: A singlecenter retrospective study
    • Atta EH, Dias DS, Marra VL, de Azevedo AM. Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: a singlecenter retrospective study. Ann Hematol 2010;89:851-859
    • (2010) Ann Hematol , vol.89 , pp. 851-859
    • Atta, E.H.1    Dias, D.S.2    Marra, V.L.3    De Azevedo, A.M.4
  • 25
    • 0036456675 scopus 로고    scopus 로고
    • Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia
    • DOI 10.1046/j.1365-2141.2002.03947.x
    • Gluckman E, Rokicka-Milewska R, Hann I, et al. Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia. Br J Haematol 2002;119:1075-1082 (Pubitemid 35463836)
    • (2002) British Journal of Haematology , vol.119 , Issue.4 , pp. 1075-1082
    • Gluckman, E.1    Rokicka-Milewska, R.2    Hann, I.3    Nikiforakis, E.4    Tavakoli, F.5    Cohen-Scali, S.6    Bacigalupo, A.7
  • 26
    • 0034096024 scopus 로고    scopus 로고
    • What is the definition of cure for aplastic anemia?
    • Camitta BM. What is the definition of cure for aplastic anemia? Acta Haematol 2000;103:16-18 (Pubitemid 30150901)
    • (2000) Acta Haematologica , vol.103 , Issue.1 , pp. 16-18
    • Camitta, B.M.1
  • 27
    • 70349213313 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of aplastic anaemia
    • Marsh JCW, Ball SE, Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol 2009;147:43-70
    • (2009) Br J Haematol , vol.147 , pp. 43-70
    • Jcw, M.1    Ball, S.E.2    Cavenagh, J.3
  • 29
    • 33646684489 scopus 로고    scopus 로고
    • Retreatment with rabbit anti-thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia
    • DOI 10.1111/j.1365-2141.2006.06098.x
    • Scheinberg P, Nunez O, Young NS. Retreatment with rabbit anti-thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia. Br J Haematol 2006;133:622-627 (Pubitemid 43742776)
    • (2006) British Journal of Haematology , vol.133 , Issue.6 , pp. 622-627
    • Scheinberg, P.1    Nunez, O.2    Young, N.S.3
  • 32
    • 28544434394 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: A report from the EBMT-SAA Working Party
    • DOI 10.1038/sj.bmt.1705165, PII 1705165
    • Bacigalupo A, Locatelli F, Lanino E, et al. Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party. Bone Marrow Transplant 2005;36:947-950 (Pubitemid 41741556)
    • (2005) Bone Marrow Transplantation , vol.36 , Issue.11 , pp. 947-950
    • Bacigalupo, A.1    Locatelli, F.2    Lanino, E.3    Marsh, J.4    Socie, G.5    Maury, S.6    Prete, A.7    Locasciulli, A.8    Cesaro, S.9    Passweg, J.10
  • 34
    • 15544377256 scopus 로고    scopus 로고
    • Marrow transplants from matched unrelated donors for aplastic anaemia using alemtuzumab, fludarabine and cyclophosphamide based conditioning
    • DOI 10.1038/sj.bmt.1704799
    • Gupta V, Ball SE, Sage D, et al. Marrow transplants from matched unrelated donors for aplastic anaemia using alemtuzumab, fludarabine and cyclophosphamide based conditioning. Bone Marrow Transplant 2005;35:467-471 (Pubitemid 40403349)
    • (2005) Bone Marrow Transplantation , vol.35 , Issue.5 , pp. 467-471
    • Gupta, V.1    Ball, S.E.2    Sage, D.3    Ortin, M.4    Freires, M.5    Gordon-Smith, E.C.6    Marsh, J.C.W.7
  • 36
    • 33645240407 scopus 로고    scopus 로고
    • Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia
    • Passweg JR, Pérez WS, Eapen M, et al. Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. Bone Marrow Transplant 2006; 37:641-649
    • (2006) Bone Marrow Transplant , vol.37 , pp. 641-649
    • Passweg, J.R.1    Pérez, W.S.2    Eapen, M.3
  • 38
    • 77953184315 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: A retrospective study from the EBMT-SAA Working Party
    • Bacigalupo A, Socie G, Lanino E, et al. Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: A retrospective study from the EBMT-SAA Working Party. Haematologica 2010;95:976-982
    • (2010) Haematologica , vol.95 , pp. 976-982
    • Bacigalupo, A.1    Socie, G.2    Lanino, E.3
  • 39
    • 0032619794 scopus 로고    scopus 로고
    • Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy
    • Deeg HJ, Seidel K, Casper J, et al. Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy. Biol Blood Marrow Transplant 1999;5:243-252
    • (1999) Biol Blood Marrow Transplant , vol.5 , pp. 243-252
    • Deeg, H.J.1    Seidel, K.2    Casper, J.3
  • 41
    • 16244393128 scopus 로고    scopus 로고
    • Non-radiotherapy conditioning with stem cell transplantation from alternative donors in children with refractory severe aplastic anemia
    • DOI 10.1038/sj.bmt.1704792
    • Urban C, Benesch M, Sykora KW, Schwinger W, Lackner H. Non-radiotherapy conditioning with stem cell transplantation from alternative donors in children with refractory severe aplastic anemia. Bone Marrow Transplant 2005;35:591-594 (Pubitemid 40450458)
    • (2005) Bone Marrow Transplantation , vol.35 , Issue.6 , pp. 591-594
    • Urban, C.1    Benesch, M.2    Sykora, K.W.3    Schwinger, W.4    Lackner, H.5
  • 44
    • 0035143045 scopus 로고    scopus 로고
    • Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia
    • DOI 10.1038/sj.bmt.1702748
    • Kremens B, Basu O, Grosse-Wilde H, Sauerwein W, Schaefer UW, Havers W. Transplantation of CD34-enriched peripheral stem cells from an HLA-haplotype mismatched donor to a patient with severe aplastic anemia. Bone Marrow Transplant 2001;27:111-113 (Pubitemid 32124417)
    • (2001) Bone Marrow Transplantation , vol.27 , Issue.1 , pp. 111-113
    • Kremens, B.1    Basu, O.2    Grosse-Wilde, H.3    Sauerwein, W.4    Schaefer, U.W.5    Havers, W.6
  • 47
    • 70350743156 scopus 로고    scopus 로고
    • Successful salvage unrelated umbilical cord blood transplantation with two units after engraftment failure with single unit in severe aplastic anemia
    • Lee JW, Kang HJ, Kim EK, Shin HY, Ahn HS. Successful salvage unrelated umbilical cord blood transplantation with two units after engraftment failure with single unit in severe aplastic anemia. J Korean Med Sci 2009;24:744-746
    • (2009) J Korean Med Sci , vol.24 , pp. 744-746
    • Lee, J.W.1    Kang, H.J.2    Kim, E.K.3    Shin, H.Y.4    Ahn, H.S.5
  • 48
    • 33646887741 scopus 로고    scopus 로고
    • Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning
    • DOI 10.1111/j.1399-3046.2006.00486.x
    • Ohga S, Ichino K, Goto K, et al. Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning. Pediatr Transplant 2006;10:497-500 (Pubitemid 43780685)
    • (2006) Pediatric Transplantation , vol.10 , Issue.4 , pp. 497-500
    • Ohga, S.1    Ichino, K.2    Goto, K.3    Hattori, S.4    Nomura, A.5    Takada, H.6    Nakamura, K.7    Hara, T.8
  • 49
    • 37349091436 scopus 로고    scopus 로고
    • Umbilical-cord blood cell transplantation conditioned with a reduced intensity-regimen is a practical salvage therapy for severe aplastic anemia refractory to immunosuppressive therapy with antithymocyte globulin/ciclosporin
    • Tajika K, Mizuki T, Nakayama K, Yamaguchi H, Dan K. Umbilical-cord blood cell transplantation conditioned with a reduced intensity-regimen is a practical salvage therapy for severe aplastic anemia refractory to immunosuppressive therapy with antithymocyte globulin/ciclosporin. J Nippon Med Sch 2007;74:424-429 (Pubitemid 350291644)
    • (2007) Journal of Nippon Medical School , vol.74 , Issue.6 , pp. 424-429
    • Tajika, K.1    Mizuki, T.2    Nakayama, K.3    Yamaguchi, H.4    Dan, K.5
  • 50
    • 0742306755 scopus 로고    scopus 로고
    • Umbilical cord blood transplant for adult patients with severe aplastic anemia using anti-lymphocyte globulin and cyclophosphamide as conditioning therapy
    • DOI 10.1038/sj.bmt.1704295
    • Mao P, Wang S, Wang S, et al. Umbilical cord blood transplant for adult patients with severe aplastic anemia using anti-lymphocyte globulin and cyclophosphamide as conditioning therapy. Bone Marrow Transplant 2004;33:33-38 (Pubitemid 38159701)
    • (2004) Bone Marrow Transplantation , vol.33 , Issue.1 , pp. 33-38
    • Mao, P.1    Wang, S.2    Wang, S.3    Zhu, Z.4    Liv, Q.5    Xuv, Y.6    Mo, W.7    Ying, Y.8
  • 51
    • 26844533706 scopus 로고    scopus 로고
    • Sustained and stable hematopoietic donor-recipient mixed chimerism after unrelated cord blood transplantation for adult patients with severe aplastic anemia
    • DOI 10.1111/j.1600-0609.2005.00538.x
    • Mao P, Zhu Z, Wang H, et al. Sustained and stable hematopoietic donor-recipient mixed chimerism after unrelated cord blood transplantation for adult patients with severe aplastic anemia. Eur J Haematol 2005;75:430-435 (Pubitemid 41445084)
    • (2005) European Journal of Haematology , vol.75 , Issue.5 , pp. 430-435
    • Mao, P.1    Zhu, Z.2    Wang, H.3    Wang, S.4    Mo, W.5    Ying, Y.6    Li, Q.7    Xu, Y.8
  • 52
    • 84858699230 scopus 로고    scopus 로고
    • Influence of nucleated cell dose on overall survival of unrelated cord blood transplant for patients with severe acquired aplastic anemia: A study by EUROCORD and the Aplastic Anemia Working Party of the EBMT
    • Peffault de Latour R, Purtill D, Ruggeri A, et al. Influence of nucleated cell dose on overall survival of unrelated cord blood transplant for patients with severe acquired aplastic anemia: a study by EUROCORD and the Aplastic Anemia Working Party of the EBMT. Biol Blood Marrow Transplant 2010; 17:78-85
    • (2010) Biol Blood Marrow Transplant , vol.17 , pp. 78-85
    • Peffault De Latour, R.1    Purtill, D.2    Ruggeri, A.3
  • 54
    • 34250662988 scopus 로고    scopus 로고
    • Mobilization, collection, and immunomagnetic selection of peripheral blood CD34 cells in recovered aplastic anemia patients
    • DOI 10.1111/j.1537-2995.2007.01258.x
    • Sloand EM, Read EJ, Scheinberg P, et al. Mobilization, collection, and immunomagnetic selection of peripheral blood CD34 cells in recovered aplastic anemia patients. Transfusion 2007;47:1250-1253 (Pubitemid 46934317)
    • (2007) Transfusion , vol.47 , Issue.7 , pp. 1250-1253
    • Sloand, E.M.1    Read, E.J.2    Scheinberg, P.3    Tang, Y.4    More, K.5    Leitman, S.F.6    Maciejewski, J.7    Young, N.S.8
  • 55
    • 76449093834 scopus 로고    scopus 로고
    • Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and single-lineage marrow failure: A pilot study and a survey from the EBMT WPSAA
    • Risitano AM, Selleri C, Serio B, et al. Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and single-lineage marrow failure: a pilot study and a survey from the EBMT WPSAA. Br J Haematol 2010;148: 791-796
    • (2010) Br J Haematol , vol.148 , pp. 791-796
    • Risitano, A.M.1    Selleri, C.2    Serio, B.3
  • 56
    • 56949093138 scopus 로고    scopus 로고
    • A pilot dose-escalating study of alemtuzumab plus cyclosporine for patients with bone marrow failure syndrome
    • Kim H, Min YJ, Baek JH, et al. A pilot dose-escalating study of alemtuzumab plus cyclosporine for patients with bone marrow failure syndrome. Leuk Res 2009;33:222-231
    • (2009) Leuk Res , vol.33 , pp. 222-231
    • Kim, H.1    Min, Y.J.2    Baek, J.H.3
  • 57
    • 77949321839 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemia
    • Gómez-Almaguer D, Jaime-Pérez JC, Garza-Rodr?́guez V, et al. Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemia. Ann Hematol 2010;89:299-303
    • (2010) Ann Hematol , vol.89 , pp. 299-303
    • Gómez-Almaguer, D.1    Jaime-Pérez, J.C.2    Garza-Rodŕguez, V.3
  • 58
    • 0030031677 scopus 로고    scopus 로고
    • Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation
    • Brodsky RA, Sensenbrenner LL, Jones RJ. Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation. Blood 1996; 87:491-494 (Pubitemid 26030304)
    • (1996) Blood , vol.87 , Issue.2 , pp. 491-494
    • Brodsky, R.A.1    Sensenbrenner, L.L.2    Jones, R.J.3
  • 60
    • 2442490982 scopus 로고    scopus 로고
    • High-dose cyclophosphamide as salvage therapy for severe aplastic anemia
    • DOI 10.1016/j.exphem.2004.02.002, PII S0301472X04000426
    • Brodsky RA, Chen AR, Brodsky I, Jomes RJ. High dose cyclophosphamide as salvage therapy for severe aplastic anemia. Exp Hematol 2004;32:435-440 (Pubitemid 38624327)
    • (2004) Experimental Hematology , vol.32 , Issue.5 , pp. 435-440
    • Brodsky, R.A.1    Chen, A.R.2    Brodsky, I.3    Jones, R.J.4
  • 61
    • 77950412952 scopus 로고    scopus 로고
    • High dose cyclophosphamide for severe aplastic anemia: Long-term follow-up
    • Brodsky RA, Chen AR, Dorr D, et al. High dose cyclophosphamide for severe aplastic anemia: long-term follow-up. Blood 2010;115:2136-2141
    • (2010) Blood , vol.115 , pp. 2136-2141
    • Brodsky, R.A.1    Chen, A.R.2    Dorr, D.3
  • 62
    • 74849111526 scopus 로고    scopus 로고
    • High-dose cycloophosphamide treatment for refractory severe aplastic anemia in children
    • Audino AN, Blatt J, Carcamo B, et al. High-dose cycloophosphamide treatment for refractory severe aplastic anemia in children. Pediatr Blood Cancer 2010;54:269-272
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 269-272
    • Audino, A.N.1    Blatt, J.2    Carcamo, B.3
  • 63
    • 0034605715 scopus 로고    scopus 로고
    • High-dose cyclophosphamide in severe aplastic anaemia: A randomised trial
    • Tisdale JF, Dunn DE, Geller N, et al. High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. Lancet 2000;356:1554-1559
    • (2000) Lancet , vol.356 , pp. 1554-1559
    • Tisdale, J.F.1    Dunn, D.E.2    Geller, N.3
  • 64
    • 0037114747 scopus 로고    scopus 로고
    • Late complications following treatment for severe aplastic anemia (SAA) with high-dose cyclophosphamide (CY): Follow-up of a randomized trial
    • DOI 10.1182/blood-2002-02-0494
    • Tisdale JF, Maciejewski JP, Nun? ez O, Rosenfeld SJ, Young NS. Late complications following treatment for severe aplastic anemia (SAA) with high-dose cyclophosphamide (Cy): follow-up of a randomized trial. Blood 2002;100: 4668-4670 (Pubitemid 35429713)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4668-4670
    • Tisdale, J.F.1    Maciejewski, J.P.2    Nunez, O.3    Rosenfeld, S.J.4    Young, N.S.5
  • 65
    • 77950438786 scopus 로고    scopus 로고
    • Cyclophosphamide in aplastic anemia?
    • Socié G. Cyclophosphamide in aplastic anemia? Blood 2010; 115:2120-2121
    • (2010) Blood , vol.115 , pp. 2120-2121
    • Socié, G.1
  • 66
    • 0018771131 scopus 로고
    • A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia
    • Camitta B, Thomas ED, Nathan DG, et al. A prospective study of androgens and bone marrow transplantation for tretament of severe aplastic anemia. Blood 1979;53:504-514 (Pubitemid 9140408)
    • (1979) Blood , vol.53 , Issue.3 , pp. 504-514
    • Camitta, B.M.1    Thomas, E.D.2    Nathan, D.G.3
  • 67
    • 0021842458 scopus 로고
    • Do androgens enhance the response to antithymocyte globulin in patients with aplastic anemia? A prospective randomized trial
    • Champlin RE, Ho WG, Feig SA, Winston DJ, Lenarsky C, Gale RP. Do androgens enhance the response to antithymocyte globulin in patients with aplastic anemia? A prospective randomized trial. Blood 1985;66:184-188 (Pubitemid 15004802)
    • (1985) Blood , vol.66 , Issue.1 , pp. 184-188
    • Champlin, R.E.1    Ho, W.G.2    Feig, S.A.3
  • 69
    • 0000566055 scopus 로고
    • Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases
    • Shahidi NT, Diamond LK. Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases. N Engl J Med 1961;264: 953-967
    • (1961) N Engl J Med , vol.264 , pp. 953-967
    • Shahidi, N.T.1    Diamond, L.K.2
  • 70
    • 70349569075 scopus 로고    scopus 로고
    • Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
    • Calado RT, Yewdell WT, Wilkerson KL, et al. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood 2009;114:2236-2243
    • (2009) Blood , vol.114 , pp. 2236-2243
    • Calado, R.T.1    Yewdell, W.T.2    Wilkerson, K.L.3
  • 72
    • 70449578590 scopus 로고    scopus 로고
    • TERTrific hormones promote hematopoiesis
    • Haneline LS. TERTrific hormones promote hematopoiesis. Blood 2009;114:2207-2208
    • (2009) Blood , vol.114 , pp. 2207-2208
    • Haneline, L.S.1
  • 73
    • 42949139242 scopus 로고    scopus 로고
    • Danazol therapy for aplastic anemia refractory to immunosuppressive therapy
    • DOI 10.1002/ajh.21118
    • Chuhjo T, Yamazaki H, Omine M, Nakao S. Danazol therapy for aplastic anemia refractory to immunosuppressive therapy. Am J Hematol 2008;83:387-389 (Pubitemid 351614752)
    • (2008) American Journal of Hematology , vol.83 , Issue.5 , pp. 387-389
    • Chuhjo, T.1    Yamazaki, H.2    Omine, M.3    Nakao, S.4
  • 74
    • 0035672698 scopus 로고    scopus 로고
    • Interferon γ and tumour necrosis factor α are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia
    • DOI 10.1046/j.1365-2141.2001.03212.x
    • Dufour C, Corcione A, Svahn J, Haupt R, Battilana N, Pistoia V. Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia. Br J Haematol 2001;115:1023-1031 (Pubitemid 34042928)
    • (2001) British Journal of Haematology , vol.115 , Issue.4 , pp. 1023-1031
    • Dufour, C.1    Corcione, A.2    Svahn, J.3    Haupt, R.4    Battilana, N.5    Pistoia, V.6
  • 75
    • 0141567661 scopus 로고    scopus 로고
    • TNF-α and IFN-γ are overexpressed in the bone marrow of Fanconi anemia patients and TNF-α suppresses erythropoiesis in vitro
    • DOI 10.1182/blood-2003-01-0114
    • Dufour C, Corcione A, Svahn J, et al. TNF-alpha and IFNgamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood 2003;102:2053-2059 (Pubitemid 37122379)
    • (2003) Blood , vol.102 , Issue.6 , pp. 2053-2059
    • Dufour, C.1    Corcione, A.2    Svahn, J.3    Haupt, R.4    Poggi, V.5    Beka'ssy, A.N.6    Scime, R.7    Pistorio, A.8    Pistoia, V.9
  • 76
    • 62449291872 scopus 로고    scopus 로고
    • Etanercept as a salvage treatment for refractory aplastic anemia
    • Dufour C, Giacchino R, Ghezzi P, et al. Etanercept as a salvage treatment for refractory aplastic anemia. Pediatr Blood Cancer 2009;52:522-525
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 522-525
    • Dufour, C.1    Giacchino, R.2    Ghezzi, P.3
  • 77
    • 33751067013 scopus 로고    scopus 로고
    • Stable response after administration of stem cell factor combined with granulocyte colony-stimulating factor in aplastic anemia
    • DOI 10.1532/IJH97.05098
    • Usuki K, Iki S, Arai S, Iijima K, Takaku F, Urabe A. Stable response after administration of stem cell factor combined with granulocyte colony-stimulating factor in aplastic anemia. Int J Hematol 2006;83:404-407 (Pubitemid 44756790)
    • (2006) International Journal of Hematology , vol.83 , Issue.5 , pp. 404-407
    • Usuki, K.1    Iki, S.2    Arai, S.3    Iijima, K.4    Takaku, F.5    Urabe, A.6
  • 78
    • 14644393642 scopus 로고    scopus 로고
    • Thrombopoietic factors in chronic bone marrow failure states: The platelet problem revisited
    • DOI 10.1158/1078-0432.CCR-04-1094
    • Kurzrock R. Thrombopoietic factors in chronic bone marrow failure states: the platelet problem revisited. Clin Cancer Res 2005;11:1361-1367 (Pubitemid 40315214)
    • (2005) Clinical Cancer Research , vol.11 , Issue.4 , pp. 1361-1367
    • Kurzrock, R.1
  • 79
    • 72449136688 scopus 로고    scopus 로고
    • The role of ancestim (recombinant human stem-cell factor, rhSCF) in hematopoietic stem cell mobilization and hematopoietic reconstitution
    • Herbert KE, Prince HM, Ritchie DS, Seymour JF. The role of ancestim (recombinant human stem-cell factor, rhSCF) in hematopoietic stem cell mobilization and hematopoietic reconstitution. Expert Opin Biol Ther 2010; 10:113-125
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 113-125
    • Herbert, K.E.1    Prince, H.M.2    Ritchie, D.S.3    Seymour, J.F.4
  • 80
    • 0029012835 scopus 로고
    • A phase I/II trial of recombinant human interleukin-6 in patients with aplastic anaemia
    • Schrezenmeier H, Marsh JC, Stromeyer P, et al. A phase I/II trial of recombinant human interleukin-6 in patients with aplastic anaemia. Br J Haematol 1995;90:283-292
    • (1995) Br J Haematol , vol.90 , pp. 283-292
    • Schrezenmeier, H.1    Marsh, J.C.2    Stromeyer, P.3
  • 82
    • 0345275884 scopus 로고    scopus 로고
    • Sequential interleukin 3 and granulocyte-macrophage-colony stimulating factor therapy in patients with bone marrow failure with long-term follow-up of responses
    • DOI 10.1002/cncr.11810
    • Wu HH, Talpaz M, Champlin RE, Pilat SR, Kurzrock R. Sequential interleukin 3 and granulocyte-macrophage-colony stimulating factor therapy in patients with bone marrow failure with long-term follow-up of responses. Cancer 2003;98:2410-2419 (Pubitemid 37466656)
    • (2003) Cancer , vol.98 , Issue.11 , pp. 2410-2419
    • Wu, H.H.1    Talpaz, M.2    Champlin, R.E.3    Pilat, S.R.4    Kurzrock, R.5
  • 83
    • 28544432438 scopus 로고    scopus 로고
    • Aplastic anemia successfully treated with rituximab
    • DOI 10.1002/ajh.20428
    • Hansen PB, Lauritzen AM. Aplastic anemia successfully treated with rituximab. Am J Hematol 2005;80:292-294 (Pubitemid 41746177)
    • (2005) American Journal of Hematology , vol.80 , Issue.4 , pp. 292-294
    • Hansen, P.B.1    Lauritzen, A.M.F.2
  • 84
    • 33750473058 scopus 로고    scopus 로고
    • Rituximab therapy of severe aplastic anemia induced by fludarabine and cyclophosphamide in a patient affected by B-cell chronic lymphocytic leukemia [12]
    • DOI 10.1080/10428190600709630, PII R12Q0078222L787N
    • Castiglioni MG, Scatena P, Pandolfo C, Mechelli S, Bianchi M. Rituximab therapy of severe aplastic anemia induced by fludarabine and cyclophosphamide in a patient affected by Bcell chronic lymphocytic leukemia. Leuk Lymphoma 2006;47: 1985-1986 (Pubitemid 44649793)
    • (2006) Leukemia and Lymphoma , vol.47 , Issue.9 , pp. 1985-1986
    • Castiglioni, M.G.1    Scatena, P.2    Pandolfo, C.3    Mechelli, S.4    Bianchi, M.5
  • 85
    • 33846868833 scopus 로고    scopus 로고
    • Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: A 25-year personal odyssey
    • DOI 10.1007/s10875-006-9060-0
    • Waldmann TA. Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune disease, and in the prevention of allograft rejection: a 25-year personal odyssey. J Clin Immunol 2007;27:1-18 (Pubitemid 46224930)
    • (2007) Journal of Clinical Immunology , vol.27 , Issue.1 , pp. 1-18
    • Waldmann, T.A.1
  • 86
    • 0242579305 scopus 로고    scopus 로고
    • Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia
    • DOI 10.1182/blood-2003-04-1032
    • Maciejewski JP, Sloand EM, Nunez O, Boss C, Young NS. Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia. Blood 2003;102:3584-3586 (Pubitemid 37409374)
    • (2003) Blood , vol.102 , Issue.10 , pp. 3584-3586
    • Maciejewski, J.P.1    Sloand, E.M.2    Nunez, O.3    Boss, C.4    Young, N.S.5
  • 87
    • 77949707207 scopus 로고    scopus 로고
    • Long-term followup of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab
    • Sloand EM, Olnes MJ, Weinstein B, et al. Long-term followup of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab. Haematologica 2010;95:382-387
    • (2010) Haematologica , vol.95 , pp. 382-387
    • Sloand, E.M.1    Olnes, M.J.2    Weinstein, B.3
  • 88
    • 14644425189 scopus 로고    scopus 로고
    • Mycophenolate mofetil as treatment of patients with acquired aplastic anaemia failing to durably respond to standard immunosuppressive treatment
    • Abstract 0363
    • Schrezenmeier H, Bacigalupo A, Dohner H, et al. Mycophenolate mofetil as treatment of patients with acquired aplastic anaemia failing to durably respond to standard immunosuppressive treatment. Bone Marrow Transplant 2003;31(Suppl. 1):Abstract 0363
    • (2003) Bone Marrow Transplant , vol.31 , Issue.SUPPL. 1
    • Schrezenmeier, H.1    Bacigalupo, A.2    Dohner, H.3
  • 89
    • 33646688643 scopus 로고    scopus 로고
    • Treatment of severe aplastic anaemia with combined immunosuppression: Anti-thymocyte globulin, ciclosporin and mycophenolate mofetil
    • DOI 10.1111/j.1365-2141.2006.06085.x
    • Scheinberg P, Nunez O, Wu C, Young NS. Treatment of severe aplastic anaemia with combined immunosuppression: anti-thymocyte globulin, ciclosporin and mycophenolate mofetil. Br J Haematol 2006;133:606-611 (Pubitemid 43742774)
    • (2006) British Journal of Haematology , vol.133 , Issue.6 , pp. 606-611
    • Scheinberg, P.1    Nunez, O.2    Wu, C.3    Young, N.S.4
  • 90
    • 62949210719 scopus 로고    scopus 로고
    • Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: A prospective randomized study
    • Scheinberg P, Wu CO, Nunez O, et al. Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study. Haematologica 2009;94:348-354
    • (2009) Haematologica , vol.94 , pp. 348-354
    • Scheinberg, P.1    Wu, C.O.2    Nunez, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.