Immunoablative high-dose cyclophosphamide without stem-cell rescue for refractory, severe autoimmune disease

Annals of Internal Medicine

Volumn 129, Issue 12, 1998, Pages 1031-1035

  Brodsky, Robert A ^a   Petri, Michelle ^b   Smith, B Douglas ^a   Seifter, Eric J ^a   Spivak, Jerry L ^b   Styler, Michael ^c   Dang, Chi V ^b   Brodsky, Isadore ^c   Jones, Richard J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; AZATHIOPRINE; COLCHICINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DANAZOL; DEXAMETHASONE; HYDROXYCHLOROQUINE; METHYLPREDNISOLONE; PREDNISONE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; VINBLASTINE;

ADULT; APLASTIC ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; REMISSION; THROMBOCYTE TRANSFUSION;

EID: 0032535657     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-129-12-199812150-00007     Document Type: Article

References (20)

1. Marmont AM, Van Bekkum DW. Stem cell transplantation for severe autoimmune diseases: new proposals but still unanswered questions. Bone Marrow Transplant. 1995;16:497-8.
2. Tyndall A, Gratwohl A. Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases. Ann Rheum Dis. 1996;55:149-51.
3. Levite M, Zinger H, Zisman E, Reisner Y, Mozes E. Beneficial effects of bone marrow transplantation on the serological manifestations and kidney pathology of experimental systemic lupus erythematosus. Cell Immunol. 1995;162:138-45.
4. Karussis DM, Vourka-Karussis U, Lehmann D, Abramsky O, Ben-Nun A, Slavin S. Immunomodulation of autoimmunity in MRL/1pr mice with syngeneic bone marrow transplantation (SBMT). Clin Exp Immunol. 1995;100: 111-7.
5. Jacobs P, Vincent MD, Mantel RW. Prolonged remission of severe refractory rheumatoid arthritis following allogeneic bone marrow transplantation for drug-induced aplastic anemia. Bone Marrow Transplant. 1986;1:237-9.
6. Lowenthal RM, Cohen ML, Atkinson K, Biggs JC. Apparent cure of rheumatoid arthritis by bone marrow transplantation. J Rheumatol. 1993;20: 137-40.
7. Euler HH, Marmont AM, Bacigalupo A, Fastenrath S, Dreger P, Hoffknecht M, et al. Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood. 1996;88: 3621-5.
8. Snowden JA, Brooks PM, Biggs JC. Haemopoietic stem cell transplantation for autoimmune diseases. Er J Haematol. 1997;99:9-22.
9. Brodsky RA, Sensenbrenner LL, Jones RJ. Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation. Blood. 1996;87:491-4.
10. Young NS. Autoimmunity and its treatment in aplastic anemia [Editorial]. Ann Intern Med. 1997;126:166-8.
11. Jones RJ, Collector MI, Barber JP, Vala MS, Fackler MJ, May WS, et al. Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity. Blood. 1996;88:487-91.
12. Gordon MY, Goldman JM, Gordon-Smith EC. 4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocyte-macrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells. Leuk Res. 1985;9:1017-21.
13. Gourley MF, Austin HA 3d, Scott D, Yarboro CH, Vaughan EM, Muir J. et al. Methylprednisolone and cydophosphamide, alone or in combination, in patients with lupus nephritis. Ann Intern Med. 1996;125:549-57.
14. Petri M, Hellmann D, Hochberg M. Validity and reliability of lupus activity measures in the routine clinic setting. J Rheumatol. 1992;19:53-9.
15. Buccheri G, Ferrigno D, Tamburini M. Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. Eur J Cancer. 1996;32A:1135-41.
16. Santos GW, Owens AH Jr. A comparison of the effects of selected cytotoxic agents on allogeneic skin graft survival in rats. Bull Hopkins Hosp. 1965;116: 327-40.
17. Zhang Q, Mayumi H, Umesue M, Tomita Y, Nomoto K, Yasui H. Fractionated dosing of cyclophosphamide for establishing long-lasting skin allograft survival, stable mixed chimerism, and intrathymic clonal deletion in mice primed with allogeneic spleen cells. Transplantation. 1997;63:1667-73.
18. Reiner A, Gernsheimer T, Slichter SJ. Pulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura. Blood. 1995;85:351-8.
19. Sanders JE, Buckner CD, Amos D, Levy W, Appelbaum FR, Doney K, et al. Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol. 1988;6:813-8.
20. Socie G, Henry-Amar M, Bacigalupo A, Hows J, Tichelli A, Ljungman P, et al. Malignant tumors occurring after treatment of aplastic anemia. N Engl J Med. 1993;329:1152-7.