A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase

Biochemistry

Volumn 44, Issue 30, 2005, Pages 10298-10304

  Wakabayashi, Hironao ^a   Su, Ya Chi ^b   Ahmad, Syed S ^b   Walsh, Peter N ^b   Fay, Philip J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; MUTAGENESIS; PHOSPHOLIPIDS; REACTION KINETICS;

PLATELET MEMBRANES; SYNTHETIC PHOSPHOLIPIDS; THROMBIN; VESICLES;

CALCIUM;

ALANINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; CALCIUM ION; GLUTAMIC ACID; THROMBIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME KINETICS; GENE MUTATION; MUTAGENESIS; NONHUMAN; PARAMETER; PHOSPHOLIPID VESICLE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; THROMBOCYTE MEMBRANE; WILD TYPE;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CALCIUM; CELL LINE; CELL MEMBRANE; COS CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; FACTOR IXA; FACTOR VIII; GLUTAMIC ACID; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PHOSPHOLIPIDS; PLATELET ACTIVATION; THROMBIN;

EID: 23044498602     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050638t     Document Type: Article

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