Pruritus and atopic dermatitis

Clinical Reviews in Allergy and Immunology

Volumn 41, Issue 3, 2011, Pages 237-244

  Darsow, Ulf ^a,b,c   Pfab, Florian ^a,b,c   Valet, Michael ^a   Huss Marp, Johannes ^b   Behrendt, Heidrun ^b,c   Ring, Johannes ^a,c   Ständer, Sonja ^d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Christine Kuhne Center for Allergy Research and Education CK CARE   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Antipruritic treatment; Atopic dermatitis; Eczema; Itch

Indexed keywords

ACETYLCHOLINE; BETA ENDORPHIN; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CLEMASTINE; CORTICOSTEROID; CYCLOSPORIN A; DIMETINDENE; DOXEPIN; DOXYLAMINE; ENKEPHALIN; GAMMA INTERFERON; HISTAMINE H4 RECEPTOR; HYDROXYZINE; INTERLEUKIN 2; INTERLEUKIN 31; KALLIKREIN; LEUKOTRIENE; NALMEFENE; NEUROTROPHIN 4; PIMECROLIMUS; PROSTAGLANDIN; SEROTONIN; SOMATOSTATIN; SUBSTANCE P; TACROLIMUS; THROMBOCYTE ACTIVATING FACTOR; TRYPTASE; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACUPUNCTURE; ANTIBIOTIC THERAPY; ARTICLE; ATOPIC DERMATITIS; BEHAVIOR MODIFICATION; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; CINGULATE GYRUS; CONTACT DERMATITIS; CORTICOSTEROID THERAPY; EPPENDORF ITCH QUESTIONNAIRE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULA; MCGILL PAIN QUESTIONNAIRE; NONHUMAN; PATHOPHYSIOLOGY; PATIENT COUNSELING; PATIENT EDUCATION; PHOTOTHERAPY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIMARY MOTOR CORTEX; PRURITUS; QUESTIONNAIRE; SCORING SYSTEM; SOMATOSENSORY CORTEX; THALAMUS; VISUAL ANALOG SCALE;

BRAIN; DERMATITIS, ATOPIC; HUMANS; PERCEPTION; PRURITUS;

EID: 79960392177     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-010-8230-2     Document Type: Article

References (64)

1. Hafenreffer S (1660) In: Kühnen B (ed) De pruritu, in Nosodochium, in quo cutis, eique adaerentium partium, affectus omnes, singulari methodo, et cognoscendi et curandi fidelissime traduntur. Ulm, pp 98-102
2. Ring J (2005) Allergy in practice. Springer, Berlin
3. U Darsow E Scharein B Bromm J Ring 1997 Skin testing of the pruritogenic activity of histamine and cytokines (interleukin-2 and tumour necrosis factor-alpha) at the dermal-epidermal junction Br J Dermatol 137 415 417 9349340 10.1111/j.1365-2133.1997.tb03749.x 1:CAS:528:DyaK2sXmslyitL0%3D (Pubitemid 27421571)
4. S Ständer M Steinhoff 2002 Pathophysiology of pruritus in atopic dermatitis: an overview Exp Dermatol 11 12 24 11952824 10.1034/j.1600-0625.2002. 110102.x (Pubitemid 36934620)
5. S Ständer M Steinhoff M Schmelz E Weisshaar D Metze T Luger 2003 Neurophysiology of pruritus: cutaneous elicitation of itch Arch Dermatol 139 1463 1470 14623706 10.1001/archderm.139.11.1463 (Pubitemid 37441284)
6. S Ständer E Weisshaar TA Luger 2008 Neurophysiological and neurochemical basis of modern pruritus treatment Exp Dermatol 17 161 169 18070080 10.1111/j.1600-0625.2007.00664.x (Pubitemid 351233860)
7. M Steinhoff J Bienenstock M Schmelz M Maurer E Wei T Biro 2006 Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus J Invest Dermatol 126 1705 1718 16845410 10.1038/sj.jid.5700231 1:CAS:528:DC%2BD28XmvFant7o%3D (Pubitemid 44102116)
8. HH Johnson GA DeOreo WP Lascheid F Mitchell 1960 Skin histamine levels in chronic atopic dermatitis J Invest Dermatol 34 237 238 14407457 1:CAS:528:DyaF3MXhtF2lt7g%3D
9. L Juhlin 1967 Localization and content of histamine in normal and diseased skin Acta Derm Venereol 47 383 391 4168800 1:STN:280: DyaF1c%2FotV2ntg%3D%3D
10. CF Wahlgren Ö Hägermark R Bergström 1990 The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis Br J Dermatol 122 545 551 2110817 10.1111/j.1365-2133.1990.tb14732.x 1:STN:280:DyaK3c3kvVaktw%3D%3D (Pubitemid 20137375)
11. D Dijkstra R Leurs P Chazot FC Shenton H Stark T Werfel, et al. 2007 Histamine downregulates monocyte CCL2 production through the histamine H4 receptor J Allergy Clin Immunol 120 300 307 17507084 10.1016/j.jaci.2007.03.024 1:CAS:528:DC%2BD2sXotlWktb0%3D (Pubitemid 47102370)
12. R Gutzmer S Mommert M Gschwandtner K Zwingmann H Stark T Werfel 2009 The histamine H4 receptor is functionally expressed on Th2 cells J Allergy Clin Immunol 123 619 625 19281909 10.1016/j.jaci.2008.12.1110 1:CAS:528: DC%2BD1MXjtFKqurw%3D
13. E Sonkoly A Muller AI Lauerma, et al. 2006 IL-31: a new link between T cells and pruritus in atopic skin inflammation J Allergy Clin Immunol 117 411 417 16461142 10.1016/j.jaci.2005.10.033 1:CAS:528:DC%2BD28XhtlCktb4%3D (Pubitemid 43192023)
14. WB Shelley RP Arthur 1957 The neurohistology and neurophysiology of the itch sensation in man AMA Arch Derm 76 296 323 13457411 1:STN:280: DyaG1c%2FgtVSjtg%3D%3D
15. S Ständer M Gunzer D Metze T Luger M Steinhoff 2002 Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin Regul Pept 110 75 83 12468112 10.1016/S0167-0115(02)00159-3 (Pubitemid 35435335)
16. J Ring T Senter RC Cornell CM Arroyave EM Tan 1978 Complement and immunoglobulin deposits in the skin of patients with atopic dermatitis Br J Dermatol 99 495 501 361063 10.1111/j.1365-2133.1978.tb02016.x 1:STN:280:DyaE1M%2FktF2ksg%3D%3D (Pubitemid 9048952)
17. MW Greaves PD Wall 1996 Pathophysiology of itching Lancet 348 938 940 8843816 10.1016/S0140-6736(96)04328-0 1:CAS:528:DyaK28XmsFCgs7s%3D (Pubitemid 26333854)
18. M Schmelz 2001 A neural pathway for itch Nat Neurosci 4 9 10 11135635 10.1038/82956 1:CAS:528:DC%2BD3MXitVehtA%3D%3D (Pubitemid 32095518)
19. M Schmelz M Hilliges R Schmidt K Orstavik C Vahlquist C Weidner, et al. 2003 Active "itch fibers" in chronic pruritus Neurology 61 564 566 12939442 1:STN:280:DC%2BD3svgtFSgtQ%3D%3D (Pubitemid 37028307)
20. M Schmelz R Schmidt A Bickel HO Handwerker HE Torebjörk 1997 Specific C-receptors for itch in human skin J Neurosci 17 8003 8008 9315918 1:CAS:528:DyaK2sXms1egu7k%3D (Pubitemid 27426235)
21. M Steinhoff U Neisius A Ikoma M Fartasch G Heyer PS Skov, et al. 2003 Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin J Neurosci 23 6176 6180 12867500 1:CAS:528:DC%2BD3sXlvVCgsr0%3D (Pubitemid 36875617)
22. U Darsow J Ring 2001 Neuroimmune interactions in the skin Curr Opin Allergy Clin Immunol 1 435 439 11964724 1:STN:280:DC%2BD383ivVWrtg%3D%3D
23. G Heyer FJ Ulmer J Schmitz HO Handwerker 1995 Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls Acta Derm Venereol 75 348 352 8615049 1:STN:280:DyaK287ovVansg%3D%3D
24. U Darsow A Drzezga M Frisch F Munz F Weilke P Bartenstein, et al. 2000 Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions J Invest Dermatol 115 1029 1033 11121137 10.1046/j.1523-1747.2000.00193.x 1:CAS:528:DC%2BD3MXhtFalsA%3D%3D (Pubitemid 32037447)
25. JC Hsieh O Hägermark M Stahle-Backdahl K Ericson L Eriksson S Stone-Elander, et al. 1994 Urge to scratch represented in the human cerebral cortex during itch J Neurophysiol 72 3004 3008 7897505 1:STN:280: DyaK2M3gsFamsw%3D%3D (Pubitemid 24382124)
26. JC Hsieh BA Meyerson M Ingvar 1999 PET study on central processing of pain in trigeminal neuropathy Eur J Pain 3 51 65 10700337 10.1016/S1090-3801(99) 90188-X (Pubitemid 29166622)
27. F Pfab M Valet T Sprenger TR Tölle GI Athanasiadis H Behrendt, et al. 2006 Short-term alternating temperature enhances histamine-induced itch: a biphasic stimulus model J Invest Dermatol 126 2673 2678 17008877 10.1038/sj.jid.5700577 1:CAS:528:DC%2BD28Xht1SgtL7M (Pubitemid 44767494)
28. F Pfab M Valet T Sprenger J Huss-Marp GI Athanasiadis HJ Baurecht A Konstantinow C Zimmer H Behrendt J Ring TR Tölle U Darsow 2010 Temperature modulated histamine-itch in lesional and nonlesional skin in atopic eczema - a combined psychophysical and neuroimaging study Allergy 65 84 94 19804445 10.1111/j.1398-9995.2009.02163.x 1:STN:280:DC%2BC3c%2FivFegsQ%3D%3D
29. M Valet F Pfab T Sprenger A Woller C Zimmer H Behrendt, et al. 2008 Cerebral processing of histamine-induced itch using short-term alternating temperature modulation-an FMRI study J Invest Dermatol 128 426 433 17657239 1:CAS:528:DC%2BD1cXmsV2luw%3D%3D
30. SG Leknes S Bantick CM Willis JD Wilkinson RG Wise I Tracey 2007 Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans J Neurophysiol 97 415 422 16914620 10.1152/jn.00070.2006 (Pubitemid 46150787)
31. H Mochizuki N Sadato DN Saito H Toyoda M Tashiro N Okamura, et al. 2007 Neural correlates of perceptual difference between itching and pain: a human fMRI study Neuroimage 36 706 717 17524669 10.1016/j.neuroimage.2007.04.003 (Pubitemid 46907645)
32. G Yosipovitch Y Ishiuji TS Patel MI Hicks Y Oshiro RA Kraft, et al. 2008 The brain processing of scratching J Invest Dermatol 128 1806 1811 18239615 10.1038/jid.2008.3 1:CAS:528:DC%2BD1cXntVeqsro%3D (Pubitemid 351847393)
33. L Herde C Forster M Strupf HO Handwerker 2007 Itch induced by a novel method leads to limbic deactivations a functional MRI study J Neurophysiol 98 2347 2356 17715198 10.1152/jn.00475.2007 (Pubitemid 47584417)
34. R Cunnington C Windischberger E Moser 2005 Premovement activity of the pre-supplementary motor area and the readiness for action: studies of time-resolved event-related functional MRI Hum Mov Sci 24 644 656 16337295 10.1016/j.humov.2005.10.001 (Pubitemid 43124617)
35. BA Vogt 2005 Pain and emotion interactions in subregions of the cingulate gyrus Nat Rev Neurosci 6 533 544 15995724 10.1038/nrn1704 1:CAS:528: DC%2BD2MXlslGnsb4%3D (Pubitemid 40942820)
36. CL Kwan AP Crawley DJ Mikulis KD Davis 2000 An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli Pain 85 359 374 10781909 10.1016/S0304-3959(99) 00287-0 1:STN:280:DC%2BD3c3ksFKhsg%3D%3D (Pubitemid 30214163)
37. TR Tölle T Kaufmann T Siessmeier S Lautenbacher A Berthele F Munz, et al. 1999 Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis Ann Neurol 45 40 47 9894875 10.1002/1531-8249(199901)45:1<40::AID-ART8>3.0. CO;2-L (Pubitemid 29036430)
38. C Buchel K Bornhovd M Quante V Glauche B Bromm C Weiller 2002 Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study J Neurosci 22 970 976 11826125 1:CAS:528:DC%2BD38XhtFynsLw%3D (Pubitemid 34141776)
39. HJ Freund 2001 The parietal lobe as a sensorimotor interface: a perspective from clinical and neuroimaging data Neuroimage 14 S142 S146 11373146 10.1006/nimg.2001.0863 1:STN:280:DC%2BD3M3ptVGrtQ%3D%3D (Pubitemid 32554543)
40. Fuster JM (1997) The prefrontal cortex. Anatomy, physiology and neuropsychology of the frontal lobe. Lippincott-Raven, Philadelphia
41. T Singer B Seymour J O'Doherty H Kaube RJ Dolan CD Frith 2004 Empathy for pain involves the affective but not sensory components of pain Science 303 1157 1162 14976305 10.1126/science.1093535 1:CAS:528:DC%2BD2cXhsVWgtLg%3D (Pubitemid 38233574)
42. RH Gracely ME Geisser T Giesecke MA Grant F Petzke DA Williams, et al. 2004 Pain catastrophizing and neural responses to pain among persons with fibromyalgia Brain 127 835 843 14960499 10.1093/brain/awh098 1:STN:280:DC%2BD2c7ltFSntw%3D%3D (Pubitemid 38478528)
43. AD Craig 2003 Interoception: the sense of the physiological condition of the body Curr Opin Neurobiol 13 500 505 12965300 10.1016/S0959-4388(03)00090-4 1:CAS:528:DC%2BD3sXntVKhsLY%3D (Pubitemid 37088242)
44. AV Apkarian MC Bushnell RD Treede JK Zubieta 2005 Human brain mechanisms of pain perception and regulation in health and disease Eur J Pain 9 463 484 15979027 10.1016/j.ejpain.2004.11.001 (Pubitemid 40836040)
45. B Bromm E Scharein U Darsow J Ring 1995 Effects of menthol and cold on histamine-induced itch and skin reactions in man Neurosci Lett 187 157 160 7624016 10.1016/0304-3940(95)11362-Z 1:CAS:528:DyaK2MXkvValtLo%3D
46. U Darsow J Ring E Scharein B Bromm 1996 Correlations between histamine-induced wheal, flare and itch Arch Dermatol Res 288 436 441 8844121 10.1007/BF02505231 1:CAS:528:DyaK28Xlt1Ohs7c%3D (Pubitemid 26282736)
47. O Hägermark CF Wahlgren 1992 Some methods for evaluating clinical itch and their application for studying pathophysiological mechanisms J Dermatol Sci 4 55 62 1419979 10.1016/0923-1811(92)90059-K (Pubitemid 23029538)
48. U Darsow VF Mautner B Bromm E Scharein J Ring 1997 The Eppendorf Pruritus Questionnaire Hautarzt 48 730 733 9441165 10.1007/s001050050651 1:STN:280:DyaK1c%2FjslSltg%3D%3D (Pubitemid 27459977)
49. U Darsow E Scharein D Simon G Walter B Bromm J Ring 2001 New aspects of itch pathophysiology: component analysis of atopic itch using the 'Eppendorf Itch Questionnaire' Int Arch Allergy Immunol 124 326 331 11307006 10.1159/000053748 1:STN:280:DC%2BD3M3mt1eruw%3D%3D (Pubitemid 32304841)
50. R Melzack 1975 The McGill Pain Questionnaire: major properties and scoring methods Pain 1 277 299 1235985 10.1016/0304-3959(75)90044-5 1:STN:280:DyaE2s3htlOhsQ%3D%3D
51. S Weissenbacher T Bacon D Targett H Behrendt J Ring U Darsow 2005 Atopy patch test-reproducibility and elicitation of itch in different application sites Acta Derm Venereol 85 147 151 15823910 10.1080/00015550410024418 (Pubitemid 40477666)
52. G Schneider S Ständer M Burgmer G Driesch G Heuft M Weckesser 2008 Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects Eur J Pain 12 834 841 18203636 10.1016/j.ejpain.2007.12.003 1:CAS:528:DC%2BD1cXps1GhtL8%3D
53. EW Monroe 1989 Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis J Am Acad Dermatol 21 135 136 2745760 10.1016/S0190-9622(89)80353-6 1:STN:280:DyaL1MzgvFensg%3D%3D (Pubitemid 19171479)
54. S Ständer E Weisshaar T Mettang JC Szepietowski E Carstens A Ikoma, et al. 2007 Clinical classification of itch: a position paper of the International Forum for the Study of Itch Acta Derm Venereol 87 291 294 17598029 10.2340/00015555-0305
55. PA Klein RA Clark 1999 An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis Arch Dermatol 135 1522 1525 10606058 10.1001/archderm.135.12.1522 1:CAS:528:DC%2BD3cXivFGhtg%3D%3D
56. IS Foulds RM MacKie 1981 A double-blind trial of the H2 receptor antagonist cimetidine, and the H1 receptor antagonist promethazine hydrochloride in the treatment of atopic dermatitis Clin Allergy 11 319 323 7028312 10.1111/j.1365-2222.1981.tb01600.x 1:STN:280:DyaL38%2FkvFSjtA%3D%3D (Pubitemid 11049537)
57. F Pfab M Hammes M Backer J Huss-Marp GI Athanasiadis TR Tölle, et al. 2005 Preventive effect of acupuncture on histamine-induced itch: a blinded, randomized, placebo-controlled, crossover trial J Allergy Clin Immunol 116 1386 1388 16337477 10.1016/j.jaci.2005.08.055 1:CAS:528:DC%2BD2MXhtlSitbbF (Pubitemid 41742239)
58. MJ Belgrade LM Solomon EA Lichter 1984 Effect of acupuncture on experimentally induced itch Acta Derm Venereol 64 129 133 6203300 1:STN:280:DyaL2c3is1yqtw%3D%3D (Pubitemid 14130452)
59. T Lundeberg L Bondesson M Thomas 1987 Effect of acupuncture on experimentally induced itch Br J Dermatol 117 771 777 3426954 10.1111/j.1365-2133.1987.tb07359.x 1:STN:280:DyaL1c7gslCgtA%3D%3D (Pubitemid 18067504)
60. MR Kesting P Thurmuller F Holzle KD Wolff T Holland-Letz M Stucker 2006 Electrical ear acupuncture reduces histamine-induced itch (alloknesis) Acta Derm Venereol 86 399 403 16955182 10.2340/00015555-0115 (Pubitemid 44450093)
61. F Pfab J Huss-Marp A Gatti J Fuqin GI Athanasiadis D Irnich U Raap W Schober H Behrendt J Ring U Darsow 2010 Influence of acupuncture on type I hypersensitivity itch and the wheal and flare response in adults with atopic eczema-a blinded, randomized, placebo-controlled, crossover trial Allergy 65 903 910 20002660 10.1111/j.1398-9995.2009.02284.x 1:STN:280:DC%2BC3cnlvFGhsw%3D%3D
62. Pfab F, Athanasiadis GI, Huss-Marp J, Fuqin J, Heuser B, Brockow K, et al. Effect of acupuncture on allergen-induced basophil activation in patients with atopic eczema-a pilot trial. submitted
63. Anonymous 2000 Doxepin cream for eczema? Drug Ther Bull 38 31 32 10.1136/dtb.2000.38431
64. J Ring K Brockow D Abeck 1996 The therapeutic concept of "patient management" in atopic eczema Allergy 51 206 215 8792916 1:STN:280:DyaK28zosFSmtA%3D%3D