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Volumn 4, Issue 4, 2011, Pages 515-523

Pharmacodynamics of TNF-α inhibitors in psoriasis

Author keywords

inflammation; mechanism of action; pharmacodynamic properties; psoriasis; TNF a inhibitors; tumor necrosis factor

Indexed keywords

ADALIMUMAB; CERTOLIZUMAB PEGOL; ETANERCEPT; GOLIMUMAB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960387059     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/ecp.11.28     Document Type: Review
Times cited : (15)

References (50)
  • 1
    • 0036145337 scopus 로고    scopus 로고
    • The immunologic basis for the treatment of psoriasis with new biologic agents
    • DOI 10.1067/mjd.2002.120568
    • Krueger JG. The immunologic basis for the treatment of psoriasis with new biologic agents. J. Am. Acad. Dermatol. 46(1), 1-23 (2002). (Pubitemid 34073472)
    • (2002) Journal of the American Academy of Dermatology , vol.46 , Issue.1 , pp. 1-23
    • Krueger, J.G.1
  • 2
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-g, interleukin-2, and tumor necrosis factor-a, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-g, interleukin-2, and tumor necrosis factor-a, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J. Invest. Dermatol. 113(5), 752-759 (1999).
    • (1999) J. Invest. Dermatol. , vol.113 , Issue.5 , pp. 752-759
    • Austin, L.M.1    Ozawa, M.2    Kikuchi, T.3    Walters, I.B.4    Krueger, J.G.5
  • 3
    • 0033953110 scopus 로고    scopus 로고
    • CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: Blood and skin comparisons by flow cytometry
    • DOI 10.1006/jaut.1999.0343
    • Ferenczi K, Burack L, Pope M, Krueger JG, Austin LM. CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J. Autoimmun. 14(1), 63-78 (2000). (Pubitemid 30080539)
    • (2000) Journal of Autoimmunity , vol.14 , Issue.1 , pp. 63-78
    • Ferenczi, K.1    Burack, L.2    Pope, M.3    Krueger, J.G.4    Austin, L.M.5
  • 4
    • 0034997575 scopus 로고    scopus 로고
    • + T cells in chronic plaque psoriasis are Tcl cells producing heterogeneous levels of interferon-gamma
    • DOI 10.1034/j.1600-0625.2001.010003168.x
    • Ovigne JM, Baker BS, Brown DW, Powles AV, Fry L. Epidermal CD8+ T cells in chronic plaque psoriasis are Tc1 cells producing heterogeneous levels of interferon-g. Exp. Dermatol. 10(3), 168-174 (2001). (Pubitemid 32492479)
    • (2001) Experimental Dermatology , vol.10 , Issue.3 , pp. 168-174
    • Ovigne, J.-M.1    Baker, B.S.2    Brown, D.W.3    Powles, A.V.4    Fry, L.5
  • 5
    • 38549176118 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
    • Tracey D, Klareskog L, Sasso EH, Salfeld JG, Tak PP. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol. Ther. 117(2), 244-279 (2008).
    • (2008) Pharmacol. Ther. , vol.117 , Issue.2 , pp. 244-279
    • Tracey, D.1    Klareskog, L.2    Sasso, E.H.3    Salfeld, J.G.4    Tak, P.P.5
  • 6
    • 30744471132 scopus 로고    scopus 로고
    • Cutting edge: Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation
    • Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Cutting edge: tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J. Immunol. 176(2), 721-725 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.2 , pp. 721-725
    • Smookler, D.S.1    Mohammed, F.F.2    Kassiri, Z.3    Duncan, G.S.4    Mak, T.W.5    Khokha, R.6
  • 7
    • 0034733682 scopus 로고    scopus 로고
    • A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling
    • DOI 10.1126/science.288.5475.2351
    • Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288(5475), 2351-2354 (2000). (Pubitemid 30448156)
    • (2000) Science , vol.288 , Issue.5475 , pp. 2351-2354
    • Chan, F.K.-M.1    Chun, H.J.2    Zheng, L.3    Siegel, R.M.4    Bui, K.L.5    Lenardo, M.J.6
  • 8
    • 0028866022 scopus 로고
    • The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
    • Grell M, Douni E, Wajant H et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83(5), 793-802 (1995).
    • (1995) Cell , vol.83 , Issue.5 , pp. 793-802
    • Grell, M.1    Douni, E.2    Wajant, H.3
  • 10
    • 0036806622 scopus 로고    scopus 로고
    • The TNF-TNF receptor system
    • DOI 10.1515/BC.2002.178
    • Hehlgans T, Mannel DN. The TNF-TNF receptor system. Biol. Chem. 383(10), 1581-1585 (2002). (Pubitemid 35282977)
    • (2002) Biological Chemistry , vol.383 , Issue.10 , pp. 1581-1585
    • Hehlgans, T.1    Mannel, D.N.2
  • 11
    • 0035380712 scopus 로고    scopus 로고
    • A novel p75TNF receptor isoform mediating NFkB activation
    • Seitz C, Muller P, Krieg RC, Mannel DN, Hehlgans T. A novel p75TNF receptor isoform mediating NFkB activation. J. Biol. Chem. 276(22), 19390-19395 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.22 , pp. 19390-19395
    • Seitz, C.1    Muller, P.2    Krieg, R.C.3    Mannel, D.N.4    Hehlgans, T.5
  • 12
    • 17944371991 scopus 로고    scopus 로고
    • The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: Players, rules and the games
    • DOI 10.1111/j.1365-2567.2005.02143.x
    • Hehlgans T, Pfeffer K. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115(1), 1-20 (2005). (Pubitemid 40598088)
    • (2005) Immunology , vol.115 , Issue.1 , pp. 1-20
    • Hehlgans, T.1    Pfeffer, K.2
  • 14
    • 0026087048 scopus 로고
    • Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-a in psoriasis
    • Nickoloff BJ, Karabin GD, Barker JN et al. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-a in psoriasis. Am. J. Pathol. 138(1), 129-140 (1991).
    • (1991) Am. J. Pathol. , vol.138 , Issue.1 , pp. 129-140
    • Nickoloff, B.J.1    Karabin, G.D.2    Barker, J.N.3
  • 15
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kB -A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. Nuclear factor-kB -a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336(15), 1066-1072 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , Issue.15 , pp. 1066-1072
    • Barnes, P.J.1    Karin, M.2
  • 17
    • 0025630715 scopus 로고
    • Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets
    • Norris DA. Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets. J. Invest. Dermatol. 95(Suppl. 6), 111-120 (1990).
    • (1990) J. Invest. Dermatol. , vol.95 , Issue.SUPPL. 6 , pp. 111-120
    • Norris, D.A.1
  • 18
    • 67349285855 scopus 로고    scopus 로고
    • VEGF, survivin and NOS overexpression in psoriatic skin: Critical role of nitric oxide synthases
    • Simonetti O, Lucarini G, Campanati A et al. VEGF, survivin and NOS overexpression in psoriatic skin: critical role of nitric oxide synthases. J. Dermatol. Sci. 54, 205-218 (2009).
    • (2009) J. Dermatol. Sci. , vol.54 , pp. 205-218
    • Simonetti, O.1    Lucarini, G.2    Campanati, A.3
  • 19
    • 55449093745 scopus 로고    scopus 로고
    • Targeting the IL12/IL-23 cytokine family in the treatment of psoriatic disease
    • Vergou T, Lima XT, Kimball AB. Targeting the IL12/IL-23 cytokine family in the treatment of psoriatic disease. Exp. Rev. Dermatol. 3(4), 453-463 (2008).
    • (2008) Exp. Rev. Dermatol. , vol.3 , Issue.4 , pp. 453-463
    • Vergou, T.1    Lima, X.T.2    Kimball, A.B.3
  • 20
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12, interleukin-23 and psoriasis
    • Torti DC, Feldman SR. Interleukin-12, interleukin-23 and psoriasis. J. Am. Acad. Dermatol. 57, 1059-1068 (2007).
    • (2007) J. Am. Acad. Dermatol. , vol.57 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 21
    • 0034729950 scopus 로고    scopus 로고
    • Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial
    • Mease PJ, Goffe BS, Metz J, VanderStoep A, Finck B, Burge DJ. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 356(9227), 385-390 (2000). (Pubitemid 30487495)
    • (2000) Lancet , vol.356 , Issue.9227 , pp. 385-390
    • Mease, P.J.1    Goffe, B.S.2    Metz, J.3    Vanderstoep, A.4    Finck, B.5    Burge, D.J.6
  • 23
    • 0028810703 scopus 로고
    • Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins
    • Scallon BJ, Trinh H, Nedelman M, Brennan FM, Feldmann M, Ghrayeb J. Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins. Cytokine 7(8), 759-770 (1995).
    • (1995) Cytokine , vol.7 , Issue.8 , pp. 759-770
    • Scallon, B.J.1    Trinh, H.2    Nedelman, M.3    Brennan, F.M.4    Feldmann, M.5    Ghrayeb, J.6
  • 25
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • Zaba LC, Cardinale I, Gilleaudeau P et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J. Exp. Med. 204(13), 3183-3194 (2007).
    • (2007) J. Exp. Med. , vol.204 , Issue.13 , pp. 3183-3194
    • Zaba, L.C.1    Cardinale, I.2    Gilleaudeau, P.3
  • 26
    • 20544451475 scopus 로고    scopus 로고
    • Differential expression of phosphorylated NF-κB/RelA in normal and psoriatic epidermis and downregulation of NF-κB in response to treatment with etanercept
    • DOI 10.1111/j.0022-202X.2005.23735.x
    • Lizzul PF, Aphale A, Malaviya R et al. Differential expression of phosphorylated NF-kB/RelA in normal and psoriatic epidermis and downregulation of NF-kB in response to treatment with etanercept. J. Invest. Dermatol. 124(6), 1275-1283 (2005). (Pubitemid 40847416)
    • (2005) Journal of Investigative Dermatology , vol.124 , Issue.6 , pp. 1275-1283
    • Lizzul, P.F.1    Aphale, A.2    Malaviya, R.3    Sun, Y.4    Masud, S.5    Dombrovskiy, V.6    Gottlieb, A.B.7
  • 28
    • 0027361432 scopus 로고
    • Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
    • Knight DM, Trinh H, Le J et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol. Immunol. 30(16), 1443-1453 (1993).
    • (1993) Mol. Immunol. , vol.30 , Issue.16 , pp. 1443-1453
    • Knight, D.M.1    Trinh Le, H.J.2
  • 29
    • 34248578489 scopus 로고    scopus 로고
    • Binding characteristics of tumor necrosis factor receptor-Fc fusion proteins vs anti-tumor necrosis factor mAbs
    • DOI 10.1038/sj.jidsymp.5650034, PII 5650034
    • Kohno T, Tam LT, Stevens SR, Louie JS. Binding characteristics of tumor necrosis factor receptor-Fc fusion proteins vs anti-tumor necrosis factor mAbs. J. Invest. Dermatol. Symp. Proc. 12(1), 5-8 (2007). (Pubitemid 46763031)
    • (2007) Journal of Investigative Dermatology Symposium Proceedings , vol.12 , Issue.1 , pp. 5-8
    • Kohno, T.1    Tam, L.-T.T.2    Stevens, S.R.3    Louie, J.S.4
  • 30
    • 0035832515 scopus 로고    scopus 로고
    • Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: A randomised trial
    • DOI 10.1016/S0140-6736(00)04954-0
    • Chaudhari U, Romano P, Mulcahy LD, Dooley LT, Baker DG, Gottlieb AB. Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 357(9271), 1842-1847 (2001). (Pubitemid 32539117)
    • (2001) Lancet , vol.357 , Issue.9271 , pp. 1842-1847
    • Chaudhari, U.1    Romano, P.2    Mulcahy, L.D.3    Dooley, L.T.4    Baker, D.G.5    Gottlieb, A.B.6
  • 31
    • 26644433889 scopus 로고    scopus 로고
    • Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: A phase III, multicentre, double-blind trial
    • DOI 10.1016/S0140-6736(05)67566-6, PII S0140673605675666
    • Reich K, Nestle FO, Papp K et al. Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a Phase III, multicentre, double-blind trial. Lancet 366(9494), 1367-1374 (2005). (Pubitemid 41443403)
    • (2005) Lancet , vol.366 , Issue.9494 , pp. 1367-1374
    • Reich, K.1    Nestle, F.O.2    Papp, K.3    Ortonne, J.-P.4    Evans, R.5    Guzzo, C.6    Li, S.7    Dooley, L.T.8    Griffiths, C.E.M.9
  • 33
    • 0028793640 scopus 로고
    • Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro
    • Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN. Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br. J. Dermatol. 133(4), 501-511 (1995).
    • (1995) Br. J. Dermatol. , vol.133 , Issue.4 , pp. 501-511
    • Leigh, I.M.1    Navsaria, H.2    Purkis, P.E.3    McKay, I.A.4    Bowden, P.E.5    Riddle, P.N.6
  • 34
  • 36
    • 34447506397 scopus 로고    scopus 로고
    • Antitumour necrosis factor-α chimeric antibody (infliximab) inhibits activation of skin-homing CD4+ and CD8+ T lymphocytes and impairs dendritic cell function
    • DOI 10.1111/j.1365-2133.2007.07945.x
    • Bedini C, Nasorri F, Girolomoni G, Pità O, Cavani A. Antitumour necrosis factor-a chimeric antibody (infliximab) inhibits activation of skin-homing CD4+ and CD8+ T lymphocytes and impairs dendritic cell function. Br. J. Dermatol. 157(2), 249-258 (2007). (Pubitemid 47083831)
    • (2007) British Journal of Dermatology , vol.157 , Issue.2 , pp. 249-258
    • Bedini, C.1    Nasorri, F.2    Girolomoni, G.3    De Pita, O.4    Cavani, A.5
  • 37
    • 34249844398 scopus 로고    scopus 로고
    • Adalimumab and infliximab bind to Fc-receptor and C1q and generate immunoprecipitation: A different mechanism from etanercept
    • Kohno T, Tam L, Ting T, Bass RB, Stevens SR. Adalimumab and infliximab bind to Fc-receptor and C1q and generate immunoprecipitation: a different mechanism from etanercept. Arthritis Rheum. 52(9), S562-S563 (2005).
    • (2005) Arthritis Rheum. , vol.52 , Issue.9
    • Kohno, T.1    Tam, L.2    Ting, T.3    Bass, R.B.4    Stevens, S.R.5
  • 38
    • 0029004771 scopus 로고
    • Chimeric anti-TNF-a monoclonal antibody cA2 binds recombinant transmembrane TNF-a and activates immune effector functions
    • Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF-a monoclonal antibody cA2 binds recombinant transmembrane TNF-a and activates immune effector functions. Cytokine 7(3), 251-259 (1995).
    • (1995) Cytokine , vol.7 , Issue.3 , pp. 251-259
    • Scallon, B.J.1    Moore, M.A.2    Trinh, H.3    Knight, D.M.4    Ghrayeb, J.5
  • 39
    • 77951518489 scopus 로고    scopus 로고
    • Targeted treatment of psoriasis with adalimumab: A critical appraisal based on a systematic review of the literature
    • Schmitt J, Wozel G. Targeted treatment of psoriasis with adalimumab: a critical appraisal based on a systematic review of the literature. Biologics 3, 303-318 (2009).
    • (2009) Biologics , vol.3 , pp. 303-318
    • Schmitt, J.1    Wozel, G.2
  • 40
    • 0035894504 scopus 로고    scopus 로고
    • Characterization of noncovalent complexes of recombinant human monoclonal antibody and antigen using cation exchange, size exclusion chromatography, and BIAcore
    • DOI 10.1006/abio.2001.5380
    • Santora LC, Kaymakcalan Z, Sakorafas P, Krull IS, Grant K. Characterization of noncovalent complexes of recombinant human monoclonal antibody and antigen using cation exchange, size exclusion chromatography, and BIAcore. Anal. Biochem. 299(2), 119-129 (2001). (Pubitemid 34053400)
    • (2001) Analytical Biochemistry , vol.299 , Issue.2 , pp. 119-129
    • Santora, L.C.1    Kaymakcalan, Z.2    Sakorafas, P.3    Krull, I.S.4    Grant, K.5
  • 41
    • 84883577100 scopus 로고    scopus 로고
    • The first decade of biologic TNF antagonists in clinical practice: Lessons learned, unresolved issues and future directions
    • Sfikakis PP. The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions. Curr. Dir. Autoimmun. 11, 180-210 (2010).
    • (2010) Curr. Dir. Autoimmun. , vol.11 , pp. 180-210
    • Sfikakis, P.P.1
  • 42
    • 34248546506 scopus 로고    scopus 로고
    • Effects of etanercept are distinct from infliximab in modulating proinflammatory genes in activated human leukocytes
    • DOI 10.1038/sj.jidsymp.5650032, PII 5650032
    • Haider AS, Cardinale IR, Whynot JA, Krueger JG. Effects of etanercept are distinct from infliximab in modulating proinflammatory genes in activated human leukocytes. J. Invest. Dermatol. Symp. Proc. 12 (1), 9-15 (2007). (Pubitemid 46763029)
    • (2007) Journal of Investigative Dermatology Symposium Proceedings , vol.12 , Issue.1 , pp. 9-15
    • Haider, A.S.1    Cardinale, I.R.2    Whynot, J.A.3    Krueger, J.G.4
  • 43
    • 38549168251 scopus 로고    scopus 로고
    • Differences in Fc receptor and C1q binding in tumor necrosis factor (TNF) antagonists may contribute to differences in mechanisms of action
    • Kohno T, Louie JS, Stevens SR. Differences in Fc receptor and C1q binding in tumor necrosis factor (TNF) antagonists may contribute to differences in mechanisms of action. J. Invest. Dermatol. 124(4), A111 (2005).
    • (2005) J. Invest. Dermatol. , vol.124 , Issue.4
    • Kohno, T.1    Louie, J.S.2    Stevens, S.R.3
  • 44
    • 63749093322 scopus 로고    scopus 로고
    • Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor
    • Kaymakcalan Z, Sakorafas P, Bose S et al. Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. Clin. Immunol. 131(2), 308-316 (2009).
    • (2009) Clin. Immunol. , vol.131 , Issue.2 , pp. 308-316
    • Kaymakcalan, Z.1    Sakorafas, P.2    Bose, S.3
  • 47
    • 34447345091 scopus 로고    scopus 로고
    • Infliximab treatment-induced formation of antibodies is common in Behcet's disease
    • Elezoglou A, Kafasi N, Kaklamanis PH et al. Infliximab treatment-induced formation of antibodies is common in Behcet's disease. Clin. Exp. Rheumatol. 25(4 Suppl. 45), S65-S69 (2007).
    • (2007) Clin. Exp. Rheumatol. , vol.25 , Issue.4-45 SUPPL.
    • Elezoglou, A.1    Kafasi, N.2    Kaklamanis, P.H.3
  • 49
  • 50
    • 33750608851 scopus 로고    scopus 로고
    • Tumor Necrosis Factor Antagonists: Different Kinetics and/or Mechanisms of Action May Explain Differences in the Risk for Developing Granulomatous Infection
    • DOI 10.1016/j.semarthrit.2006.02.001, PII S0049017206000229
    • Furst DE, Wallis RS, Broder M, Beenhouwer DO. Tumor necrosis factor antagonists: different kinetics and/or mechanisms of action may explain differences in the risk for developing granulomatous infection. Semin. Arthritis Rheum. 36(3), 159-167 (2006). (Pubitemid 44691882)
    • (2006) Seminars in Arthritis and Rheumatism , vol.36 , Issue.3 , pp. 159-167
    • Furst, D.E.1    Wallis, R.2    Broder, M.3    Beenhouwer, D.O.4


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