Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access

Radiotherapy and Oncology

Volumn 99, Issue 3, 2011, Pages 317-322

  Dittmann, Klaus ^a   Mayer, Claus ^a   Fehrenbacher, Birgit ^a   Schaller, Martin ^a   Kehlbach, Rainer ^a   Rodemann, H Peter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

ATM; DNA repair; Histone H3; Nuclear EGFR; TIP60

Indexed keywords

ATM PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HETEROCHROMATIN PROTEIN 1; HISTONE H2AX; HISTONE H3; NUCLEAR EPIDERMAL GROWTH FACTOR RECEPTOR; PROMYELOCYTIC LEUKEMIA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CHROMATIN; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DNA DAMAGE; DNA REPAIR; ENZYME KINETICS; GENE ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; WESTERN BLOTTING;

BLOTTING, WESTERN; BRONCHIAL NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CHROMATIN; DNA DAMAGE; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICROSCOPY, CONFOCAL; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; UP-REGULATION;

EID: 79960379461     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.06.001     Document Type: Article

References (29)

1. M. Baumann, M. Krause, and E. Dikomey EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms Radiother Oncol 83 2007 238 248 (Pubitemid 46915540)
2. K. Dittmann, C. Mayer, B. Fehrenbacher, M. Schaller, R. Kehlbach, and H.P. Rodemann Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654 FEBS Lett 584 2010 3878 3884
3. K. Dittmann, C. Mayer, and B. Fehrenbacher Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase J Biol Chem 280 2005 31182 31189 (Pubitemid 41291855)
4. K. Dittmann, C. Mayer, R. Kehlbach, M.C. Rothmund, and H.Peter Rodemann Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport Radiother Oncol 92 2009 379 382
5. W. Fischle Tip60-ing the balance in DSB repair Nat Cell Biol 11 2009 1279 1281
6. S.E. Golding, R.N. Morgan, B.R. Adams, A.J. Hawkins, L.F. Povirk, and K. Valerie Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells Cancer Biol Ther 8 2009 730 738
7. A.A. Goodarzi, A.T. Noon, and D. Deckbar ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin Mol Cell 31 2008 167 177 (Pubitemid 352001394)
8. A.A. Goodarzi, A.T. Noon, and P.A. Jeggo The impact of heterochromatin on DSB repair Biochem Soc Trans 37 2009 569 576
9. P. Hemmerich KAP1: a new link between the DNA damage response and PML nuclear bodies Cell Cycle 10 2011 576 577
10. Z. Jing, L. Gong, and C.-Y. Xie Reverse resistance to radiation in KYSE-150R esophageal carcinoma cell after epidermal growth factor receptor signal pathway inhibition by cetuximab Radiother Oncol: J Eur Society Ther Radiol Oncol 93 2009 468 473
11. R. Kepkay, K.M. Attwood, Y. Ziv, Y. Shiloh, and G. Dellaire KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin Cell Cycle 10 2011 308 322
12. E.M. Khan, J.M. Heidinger, M. Levy, M.P. Lisanti, T. Ravid, and T. Goldkorn Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking J Biol Chem 281 2006 14486 14493 (Pubitemid 43848379)
13. I.A. Kim, M. No, and J.M. Lee Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: potential role of histone deacetylase 6 Radiother Oncol: J Eur Society Ther Radiol Oncol 92 2009 125 132
14. S.V. Kozlov, M.E. Graham, and B. Jakob Autophosphorylation and ATM activation: additional sites add to the complexity J Biol Chem 286 2011 9107 9119
15. C. Li, M. Iida, E.F. Dunn, and D.L. Wheeler Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma Radiother Oncol 97 2010 330 337
16. S.Y. Lin, K. Makino, and W. Xia Nuclear localization of EGF receptor and its potential new role as a transcription factor Nat Cell Biol 3 2001 802 808 (Pubitemid 32842685)
17. P.A. Martinez-Carpio, and M.A. Trelles Cutaneous epidermal growth factor receptor system following ultraviolet irradiation: exploring the role of molecular mechanisms Photodermatol Photoimmunol Photomed 26 2010 250 256
18. R.E. Meyn, A. Munshi, J.V. Haymach, L. Milas, and K.K. Ang Receptor signaling as a regulatory mechanism of DNA repair Radiother Oncol 92 2009 316 322
19. M. Niyazi, A. Siefert, and S.B. Schwarz Therapeutic options for recurrent malignant glioma Radiothe Oncol: J Eur Society Ther Radiol and Oncol 98 2011 1 14
20. E. Riballo, M. Kuhne, and N. Rief A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Mol Cell 16 2004 715 724 (Pubitemid 39586530)
21. H.P. Rodemann, K. Dittmann, and M. Toulany Radiation-induced EGFR-signaling and control of DNA-damage repair Int J Radiat Biol 83 2007 781 791 (Pubitemid 350219102)
22. A. Santiago, W. Eicheler, and J. Bussink Effect of cetuximab and fractionated irradiation on tumour micro-environment Radiother Oncol 97 2010 322 329
23. I. Skvortsova, S. Skvortsov, and U. Raju Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse Radiother Oncol 96 2010 108 115
24. Y. Sun, X. Jiang, S. Chen, N. Fernandes, and B.D. Price A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM Proc Natl Acad Sci U S A 102 2005 13182 13187 (Pubitemid 41324998)
25. M. Toulany, M. Baumann, and H.P. Rodemann Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity Mol Cancer Res 5 2007 863 872 (Pubitemid 47294813)
26. M. Toulany, M. Minjgee, R. Kehlbach, J. Chen, M. Baumann, and H.P. Rodemann ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway Radiother Oncol 97 2010 338 345
27. M. Verheij, C. Vens, and B. van Triest Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective Drug Resist Updat 13 2010 29 43
28. N. Zhang, K. Erjala, and J. Kulmala Concurrent cetuximab, cisplatin, and radiation for squamous cell carcinoma of the head and neck in vitro Radiother Oncol: J Eur Society Ther Radiol Oncol 92 2009 388 392
29. H. Zhu, J. Yue, and Z. Pan Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination, non-homologous end joining PLoS One 5 2010 e12055