P53-Upregulated modulator of apoptosis (PUMA): A novel proapoptotic molecule in the failing heart

Circulation

Volumn 124, Issue 1, 2011, Pages 7-8

  Altin, S Elissa ^a   Schulze, P Christian ^a  

^a Department of Medicine   (United States)

Author keywords

apoptosis; Editorials; heart failure

Indexed keywords

CASPASE 3; DNA; PUMA PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTERIAL WALL THICKNESS; BODY WEIGHT; DISEASE COURSE; DNA DAMAGE; EDITORIAL; GAMMA RADIATION; GENE DELETION; HEART CONTRACTION; HEART FAILURE; HEART VENTRICLE HYPERTROPHY; MYOCARDIAL DISEASE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBROSIS; HEART FAILURE; MICE; MICE, KNOCKOUT; MYOCARDIUM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 79960364797     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.036178     Document Type: Editorial

References (10)

1. Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy. N Engl J Med. 1999;341:1276-1283.
2. Buja LM, Vela D. Cardiomyocyte death and renewal in the normal and diseased heart. Cardiovasc Pathol. 2008;17:349-374.
3. Kang PM, Izumo S. Apoptosis and heart failure: a critical review of the literature. Circ Res. 2000;86:1107-1113. (Pubitemid 30396034)
4. Mandl A, Pham LH, Zambetti G, Toth K, Erhardt P. Puma deletion delays cardiac dysfunction in murine heart failure models through attenuation of apoptosis. Circulation. 2011;124:31-39.
5. Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene. 2008;27(suppl 1):S71-S83.
6. Mustata G, Li M, Zevola N, Bakan A, Zhang L, Epperly M, Greenberger JS, Yu J, Bahar I. Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Topics Med Chem. 2011; 11:281-290.
7. Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood. 2010;115: 4707-4714.
8. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A. BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation-and glucocorticoid-induced apo-ptosis of lymphoid cells in vivo. Blood. 2005;106:4131-4138. (Pubitemid 41775918)
9. Toth A, Jeffers JR, Nickson P, Min JY, Morgan JP, Zambetti GP, Erhardt P. Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2006;291:52-60.
10. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53. Science. 2005;309:1732-1735. (Pubitemid 41285944)