Potential protective immunogenicity of recombinant clostridium perfringens α-β2-β1 fusion toxin in mice, sows and cows

Vaccine

Volumn 29, Issue 33, 2011, Pages 5459-5466

  Zeng, Jin ^a   Deng, Guangcun ^a   Wang, Jing ^a   Zhou, Jing ^a   Liu, Xiaoming ^a   Xie, Qing ^a   Wang, Yujiong ^a  

^a NINGXIA UNIVERSITY   (China)

Author keywords

Clostridium perfringens; Cow; Immunogenicity; Swine; Toxin; Vaccine

Indexed keywords

ALPHA TOXIN; CLOSTRIDIUM TOXIN; CPAB2B1 TOXIN; CPB2B1 TOXIN; NEUTRALIZING ANTIBODY; SECRETORY IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; COW; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOW (SWINE); SURVIVAL RATE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, NEUTRALIZING; BACTERIAL TOXINS; BACTERIAL VACCINES; CALCIUM-BINDING PROTEINS; CATTLE; CLOSTRIDIUM INFECTIONS; CLOSTRIDIUM PERFRINGENS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED ICR; PREGNANCY; RECOMBINANT FUSION PROTEINS; RODENT DISEASES; SERUM; SURVIVAL ANALYSIS; SWINE; TYPE C PHOSPHOLIPASES; VACCINES, SYNTHETIC;

EID: 79960361219     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.05.059     Document Type: Article

References (43)

1. Niilo L. Clostridium perfringens in animal disease: a review of current knowledge. Can Vet J 1980, 21(May (5)):141-148.
2. Titball R.W. Clostridium perfringens vaccines. Vaccine 2009, 27(November (Suppl. 4)):D44-D47.
3. Rood J.I. Virulence genes of Clostridium perfringens. Annu Rev Microbiol 1998, 52:333-360.
4. Petit L., Gibert M., Popoff M.R. Clostridium perfringens: toxinotype and genotype. Trends Microbiol 1999, 7(May (3)):104-110.
5. McClane B.A. Clostridial enterotoxins 2005, CRC Press, Boca Raton.
6. Niilo L. Toxigenic characteristics of Clostridium perfringens type C in enterotoxemia of domestic animals. Can J Vet Res 1987, 51(April (2)):224-228.
7. Niilo L. Clostridium perfringens type C enterotoxemia. Can Vet J 1988, 29(August (8)):658-664.
8. Sayeed S., Uzal F.A., Fisher D.J., Saputo J., Vidal J.E., Chen Y., et al. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol Microbiol 2008, 67(January (1)):15-30.
9. Lawrence G.W., Lehmann D., Anian G., Coakley C.A., Saleu G., Barker M.J., et al. Impact of active immunisation against enteritis necroticans in Papua New Guinea. Lancet 1990, 336(November (8724)):1165-1167.
10. Vidal J.E., McClane B.A., Saputo J., Parker J., Uzal F.A. Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon. Infect Immun 2008, 76(October (10)):4396-4404.
11. Songer J.G., Uzal F.A. Clostridial enteric infections in pigs. J Vet Diagn Invest 2005, 17(November (6)):528-536.
12. Miclard J., Jaggi M., Sutter E., Wyder M., Grabscheid B., Posthaus H. Clostridium perfringens beta-toxin targets endothelial cells in necrotizing enteritis in piglets. Vet Microbiol 2009, 137(June (3-4)):320-325.
13. Gibert M., Jolivet-Reynaud C., Popoff M.R. Beta2 toxin, a novel toxin produced by Clostridium perfringens. Gene 1997, 203(December (1)):65-73.
14. Gurjar A., Li J., McClane B.A. Characterization of toxin plasmids in Clostridium perfringens type C isolates. Infect Immun 2010, 78(November (11)):4860-4869.
15. Herholz C., Miserez R., Nicolet J., Frey J., Popoff M., Gibert M., et al. Prevalence of beta2-toxigenic Clostridium perfringens in horses with intestinal disorders. J Clin Microbiol 1999, 37(February (2)):358-361.
16. van Asten A.J., Nikolaou G.N., Grone A. The occurrence of cpb2-toxigenic Clostridium perfringens and the possible role of the beta2-toxin in enteric disease of domestic animals, wild animals and humans. Vet J 2010, 183(February (2)):135-140.
17. Bergeland M.E. Pathogenesis and immunity of Clostridium perfringens type C enteritis in swine. J Am Vet Med Assoc 1972, 160(February (4)):568-571.
18. Williamson E.D., Titball R.W. A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene. Vaccine 1993, 11(September (12)):1253-1258.
19. Bennett A.M., Lescott T., Phillpotts R.J., Mackett M., Titball R.W. Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin. Viral Immunol 1999, 12(2):97-105.
20. Cooper K.K., Trinh H.T., Songer J.G. Immunization with recombinant alpha toxin partially protects broiler chicks against experimental challenge with Clostridium perfringens. Vet Microbiol 2009, 133(January (1-2)):92-97.
21. Hoang T.H., Hong H.A., Clark G.C., Titball R.W., Cutting S.M. Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis. Infect Immun 2008, 76(November (11)):5257-5265.
22. Neeson B.N., Clark G.C., Atkins H.S., Lingard B., Titball R.W. Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C. Microb Pathog 2007, 43(October (4)):161-165.
23. Schoepe H., Neubauer A., Schlapp T., Wieler L.H., Baljer G. Immunization with an alphatoxin variant 121A/91-R212H protects mice against Clostridium perfringens alphatoxin. Anaerobe 2006, 12(February (1)):44-48.
24. Zekarias B., Mo H., Curtiss R. Recombinant attenuated Salmonella enterica serovar typhimurium expressing the carboxy-terminal domain of alpha toxin from Clostridium perfringens induces protective responses against necrotic enteritis in chickens. Clin Vaccine Immunol 2008, 15(May (5)):805-816.
25. Chandran D., Naidu S.S., Sugumar P., Rani G.S., Vijayan S.P., Mathur D., et al. Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus against enterotoxemia and sheep pox. Clin Vaccine Immunol 2010, 17(June (6)):1013-1016.
26. Goswami P.P., Rupa P., Prihar N.S., Garg L.C. Molecular cloning of Clostridium perfringens epsilon-toxin gene and its high level expression in E. coli. Biochem Biophys Res Commun 1996, 226(September (3)):735-740.
27. Oyston P.C., Payne D.W., Havard H.L., Williamson E.D., Titball R.W. Production of a non-toxic site-directed mutant of Clostridium perfringens epsilon-toxin which induces protective immunity in mice. Microbiology 1998, 144(February (Pt. 2)):333-341.
28. Souza A.M., Reis J.K., Assis R.A., Horta C.C., Siqueira F.F., Facchin S., et al. Molecular cloning and expression of epsilon toxin from Clostridium perfringens type D and tests of animal immunization. Genet Mol Res 2010, 9(1):266-276.
29. Miclard J., van Baarlen J., Wyder M., Grabscheid B., Posthaus H. Clostridium perfringens beta-toxin binding to vascular endothelial cells in a human case of enteritis necroticans. J Med Microbiol 2009, 58(June (Pt. 6)):826-828.
30. Nikolaou G.N., Kik M.J., van Asten A.J., Grone A. Beta2-toxin of Clostridium perfringens in a hamadryas baboon (Papio hamadryas) with enteritis. J Zoo Wildl Med 2009, 40(December (4)):806-808.
31. Uzal F.A., Fisher D.J., Saputo J., Sayeed S., McClane B.A., Songer G., et al. Ulcerative enterocolitis in two goats associated with enterotoxin- and beta2 toxin-positive Clostridium perfringens type D. J Vet Diagn Invest 2008, 20(September (5)):668-672.
32. Hauer P.J., Yeary T.J., Rosenbusch R.F. Evidence of the protective immunogenicity of native and recombinant Clostridium haemolyticum phospholipase C (beta toxin) in guinea pigs. Vaccine 2006, 24(January (2)):124-132.
33. Xu C.B., Zeng J., Xu C.L., Wang Y.J. Fusion of betal-toxin gene and beta2-toxin gene from Clostridium perfringens type C. Wei Sheng Wu Xue Bao 2005, 45(April (2)):205-208.
34. Bai J.N., Zhang Y., Zhao B.H. Cloning of alpha-beta fusion gene from Clostridium perfringens and its expression. World J Gastroenterol 2006, 12(February (8)):1229-1234.
35. Hunter S.E., Brown J.E., Oyston P.C., Sakurai J., Titball R.W. Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect Immun 1993, 61(September (9)):3958-3965.
36. Titball R.W., Naylor C.E., Basak A.K. The Clostridium perfringens alpha-toxin. Anaerobe 1999, 5(April (2)):51-64.
37. Wood K.R. An alternative to the toxin neutralization assay in mice for the potency testing of the Clostridium tetani, Clostridium septicum, Clostridium novyi type B and Clostridium perfringens type D epsilon components of multivalent sheep vaccines. Biologicals 1991, 19(October (4)):281-286.
38. Fisher D.J., Fernandez-Miyakawa M.E., Sayeed S., Poon R., Adams V., Rood J.I., et al. Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model. Infect Immun 2006, 74(September (9)):5200-5210.
39. McClane B. Clostridium perfringens type C isolates rapidly upregulate their toxin production upon contact with host cells: new insights into virulence?. Virulence 2010, 1(March-April (2)):97-100.
40. Vidal J.E., Ohtani K., Shimizu T., McClane B.A. Contact with enterocyte-like Caco-2 cells induces rapid upregulation of toxin production by Clostridium perfringens type C isolates. Cell Microbiol 2009, 11(September (9)):1306-1328.
41. Songer J.G. Clostridia as agents of zoonotic disease. Vet Microbiol 2010, 140(January (3-4)):399-404.
42. Nagahama M., Kihara A., Kintoh H., Oda M., Sakurai J. Involvement of tumour necrosis factor-alpha in Clostridium perfringens beta-toxin-induced plasma extravasation in mice. Br J Pharmacol 2008, 153(March (6)):1296-1302.
43. Johnson S. Antibody responses to clostridial infection in humans. Clin Infect Dis 1997, 25(September (Suppl. 2)):S173-S177.