Formulation design and evaluation of self micro emulsifying drug delivery system (SMEDDS) of valproic acid

Jordan Journal of Pharmaceutical Sciences

Volumn 3, Issue 2, 2010, Pages 117-125

  Nagaraju Patro, M ^a   Yadav, Adhikrao V ^a  

^a Govt College of Pharmacy   (India)

Author keywords

Formulation; Poorly water soluble drug; Pseudo ternary diagram; SMEDDS; Valproic acid

Indexed keywords

ALCOHOL; CASTOR OIL; CORN OIL; CREMAPHOR RH 40; DRUG VEHICLE; GELUCIRE; MACROGOL 200; MACROGOL 400; OLEIC ACID ETHYL ESTER; PLUROL OLEIQUE 497; POLYSORBATE 80; SOFTISAN; SOLUBILIZER; SORBITAN OLEATE; SURFACTANT; UNCLASSIFIED DRUG; VALPROIC ACID;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; IN VITRO STUDY; MICROEMULSION; PARTICLE SIZE; PHASE SEPARATION; PRECIPITATION; ROOM TEMPERATURE; SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM; SHELF LIFE;

EID: 79960331639     PISSN: 19957157     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. th ed., New York Raven Press, 1995; 605-620.
2. Tamai I, Tsuji A. "Transporter - mediated permeability of drug across the blood-brain-barrier," J. Pharm Sci., 2000;89:1371-1388.
3. Amidon GL, Shah VP, Crison JR. "Theoritical basis of biopharmaceutical classification of the correlation in vitro drug product dissolution of drug to bioavailability," Pharm Res.,1995; 413-420.
4. Clark DE. "Rapid calculaton of polar molecular surface end and its application in the predicaton of transport phenomenon," J. Pharm Sci., 1999; 88:807-814.
5. Trapani G, Cutrignelli A, Latrofa A., et. al. "Valproic acid-hydrophillic cyclodextrin complexes and valproic acid- solid dispersions: evaluation of their potential pharmaceutical use," Drug devel. ind pharm., 2004;30:53-64.
6. Fatouros DG, Karpf FS, Mullertz NA., et. al. "Clinal studies with oral lipid based formulation of poorly soluble compounds," J. Clin Pharm., 1998;15:221-231.
7. De Illiano BG, Quintana de GA. "HPLC determination of valproic acid with human plasma by derivatisation with nitrobenzyl-N, N -diisopropylisourea. J. Chrom., 2005;12:540-543.
8. Lucarelli C, Villa P, Lombaradi E, Prandini P. "HPLC method for the simultaneous analysis of valproic acid and other common anticonvulsant drugs in human plasma serum," Chromatographia, 1992;5:412-423.
9. Ioffe V, Kalendarev T, Rubinstein I. "Reverse phase HPLC for polar lipids. Simple and selective HPLC procedures for analysis of phospholipid-based derivatives of valproic acid and various non-steroidal anti-inflammatory drugs Journal of pharmaceutical and biomedical analysis," J. Pharm and biomed analysis. 2002;7: 391-403.
10. Katsuhiko M, Tomofumi O, Mitsuhiro N. "A simple and rapid determination of valproic acid in human plasma using a non-porous silica column and liquid chromatography with tandem mass spectrometric detection," Biomed Chroma. 2007; 22: 387-393.
11. Prapaporn B, Karen K, Anja G. "Characterization of Microemulsion Structures in the Pseudoternary Phase Diagram of Isopropyl Palmitate/Water/Brij 97:1-Butanol" AAPS PharmSciTech., 2006; 15.
12. Patrick H, Nigel MD, Uwe V. "Pseudo-ternary phase diagram of aqueous mixtures of Quil A cholesterol and phospholipids prepared the lipid- film hydration method," Int J Pharm Sci., 2004; 270: 229-239.
13. A. Martin. A book on physical pharmaceutical sciences. 4th ed UK, Lippincott Williams 156-171, 1999.
14. Lawrence MJ, Rees GD Emulsion based media as a novel delivery systems. Adv. Drug Deliv. Rev 2000;45:89-121
15. Patil P, Joshi P, Paradkar A. Effect of formulation variables on preparation and evaluation of self emulsifying drug delivery system (SMEDDS) of detoprofen. AAPS SciTech. 2004;5:321-329.
16. Patel AR, Vavia PR. Preparation and in vivo evaluation of SMEDDS containing fenofibrate. AAPS SciTech. 2007;9:231-236
17. Gursoy RN, Benita S. Self emulsifying drug delivery system (SMEDDS) for improved drug delivery of lipophillic drug. Biomed. Pharmaco. 2004; 58:173-182.
18. Gershanik T, Benita S. Self dispersing lipid formulations for improving oral absorption of lipophillic drugs Eur J Pharm. Biopharm. 2000;50:173-182.
19. Woo JS, Song YK, Ji-Yeon Hong. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Euro J Pharma Scis 2008;33:159-165.
20. Constantinides PP, Scalart JP. Formulation and physical characterization of water-in-oil microemulsions containing long versus medium chain length glycerides. Int. J Pharm 1997;158:57-68.
21. Pouton C. Self emulsifying drug delivery. Adv. Drug Deliv. Rev 1996; 19: 154-159.