Multiscale modeling of calcium cycling in cardiac ventricular myocyte: Macroscopic consequences of microscopic dyadic function

Biophysical Journal

Volumn 100, Issue 12, 2011, Pages 2904-2912

  Gaur, Namit ^a   Rudy, Yoram ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960331051     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.05.031     Document Type: Article

References (36)

1. Franzini-Armstrong, C., F. Protasi, and P. Tijskens. 2005. The assembly of calcium release units in cardiac muscle. Ann. N. Y. Acad. Sci. 1047:76-85. (Pubitemid 41123829)
2. Fabiato, A. 1985. Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J. Gen. Physiol. 85:247-289. (Pubitemid 15130972)
3. Cheng, H., W. J. Lederer, and M. B. Cannell. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 262:740-744. (Pubitemid 23350693)
4. Soeller, C., and M. B. Cannell. 1999. Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circ. Res. 84:266-275. (Pubitemid 29095567)
5. Cheng, H., M. B. Cannell, and W. J. Lederer. 1994. Propagation of excitation-contraction coupling into ventricular myocytes. Pflugers Arch. 428:415-417. (Pubitemid 24287396)
6. Song, L. S., E. A. Sobie, ..., H. Cheng. 2006. Orphaned ryanodine receptors in the failing heart. Proc. Natl. Acad. Sci. USA. 103:4305- 4310.
7. Takeshima, H., S. Komazaki, ..., K. Kangawa. 2000. Junctophilins: a novel family of junctional membrane complex proteins. Mol. Cell. 6:11-22.
8. van Oort, R. J., A. Garbino, ..., X. H. Wehrens. 2011. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 123:979-988.
9. MacLennan, D. H., and P. T. Wong. 1971. Isolation of a calciumsequestering protein from sarcoplasmic reticulum. Proc. Natl. Acad. Sci. USA. 68:1231-1235.
10. Györke, I., N. Hester, ..., S. Györke. 2004. The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys. J. 86:2121-2128. (Pubitemid 38524402)
11. Rizzi, N., N. Liu, ..., S. G. Priori. 2008. Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model. Circ. Res. 103:298-306.
12. 2+ handling and causes complex ventricular arrhythmias in mice. Cardiovasc. Res. 75:69-78. (Pubitemid 46873510)
13. 2+ channel and its role in myocyte electrophysiology: a theoretical investigation. Biophys. J. 92:1522-1543. (Pubitemid 46393464)
14. 2+ channels and ryanodine receptors in heart cells. Nature. 410:592-596. (Pubitemid 32267204)
15. Smith, G. D., J. E. Keizer, ..., H. Cheng. 1998. A simple numerical model of calcium spark formation and detection in cardiac myocytes. Biophys. J. 75:15-32. (Pubitemid 28311793)
16. Sobie, E. A., K. W. Dilly, ..., M. S. Jafri. 2002. Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calciuminduced calcium release. Biophys. J. 83:59-78. (Pubitemid 34694720)
17. 2+ sensing sites. Biophys. J. 75:2801-2810. (Pubitemid 28548950)
18. Wier, W. G., and C. W. Balke. 1999. Ca(2+) release mechanisms, Ca(2+) sparks, and local control of excitation-contraction coupling in normal heart muscle. Circ. Res. 85:770-776. (Pubitemid 29504151)
19. 2+ reserve. Circ. Res. 93:40-45. (Pubitemid 36859039)
20. Wier, W. G., T. M. Egan, ..., C. W. Balke. 1994. Local control of excitation- contraction coupling in rat heart cells. J. Physiol. 474:463-471. (Pubitemid 24060779)
21. Gómez, A. M., S. Guatimosim, ..., W. J. Lederer. 2001. Heart failure after myocardial infarction: altered excitation-contraction coupling. Circulation. 104:688-693. (Pubitemid 32738524)
22. Gómez, A. M., H. H. Valdivia, ..., W. J. Lederer. 1997. Defective excitation- contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 276:800-806. (Pubitemid 27199861)
23. Thomas, G., M. Chung, and C. J. Cohen. 1985. A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent. Circ. Res. 56:87-96. (Pubitemid 15130243)
24. Litwin, S. E., D. Zhang, and J. H. Bridge. 2000. Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts. Circ. Res. 87:1040-1047.
25. Ogrodnik, J., and E. Niggli. 2010. Increased Ca(2+) leak and spatiotemporal coherence of Ca(2+) release in cardiomyocytes during b-adrenergic stimulation. J. Physiol. 588:225-242.
26. Sah, R., R. J. Ramirez, and P. H. Backx. 2002. Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ. Res. 90:165-173. (Pubitemid 34627085)
27. Kubalova, Z., D. Terentyev, ..., S. Györke. 2005. Abnormal intrastore calcium signaling in chronic heart failure. Proc. Natl. Acad. Sci. USA. 102:14104-14109. (Pubitemid 41377710)
28. Bers, D. M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic Publishers, Dordrecht/Boston.
29. Györke, S., I. Györke, ..., T. F. Wiesner. 2002. Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. Front. Biosci. 7:d1454-d1463.
30. Sobie, E. A., L. S. Song, andW. J. Lederer. 2006. Restitution of Ca(2+) release and vulnerability to arrhythmias. J. Cardiovasc. Electrophysiol. 17 (Suppl 1):S64-S70.
31. 2+ release, and catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest. 116:2510-2520. (Pubitemid 44330150)
32. Song, L., R. Alcalai, ..., J. G. Seidman. 2007. Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest. 117:1814-1823. (Pubitemid 47036315)
33. 2+ store throughout cardiac myocyte. Circ. Res. 99:283-291. (Pubitemid 44174936)
34. 2+ blinks: rapid nanoscopic store calcium signaling. Proc. Natl. Acad. Sci. USA. 102:3099- 3104. (Pubitemid 40299922)
35. 2+ diffusion. Circ. Res. 103:e105-e115.
36. Laver, D. R. 2009. Luminal Ca(2+) activation of cardiac ryanodine receptors by luminal and cytoplasmic domains. Eur. Biophys. J. 39:19-26.