The relationship between the neuromodulator adenosine and behavioral symptoms of autism

Neuroscience Letters

Volumn 500, Issue 1, 2011, Pages 1-5

  Masino, Susan A ^a   Kawamura, Masahito ^a,e   Plotkin, Louisa M ^a   Svedova, Julia ^a   DiMario, Francis J ^b,c   Eigsti, Inge Marie ^d  

^a TRINITY COLLEGE   (United States)

^b Children's Medical Center   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Asperger syndrome; ATP; Autism spectrum disorders; Behavior; Ketogenic diet; Metabolism; Purine

Indexed keywords

ADENOSINE;

ADOLESCENT; ADULT; AGGRESSION; ANXIETY; ASPERGER SYNDROME; AUTISM; BATH; BEHAVIOR CHANGE; CHILD; CHILD BEHAVIOR; CONTROLLED STUDY; FEMALE; FEVER; GENERAL ANESTHESIA; HEAD INJURY; HUMAN; JUMPING; KETOGENIC DIET; MAJOR CLINICAL STUDY; MALE; MASSAGE; NOTE; PARENT; PATIENT PARTICIPATION; PHYSICAL SENSITIVITY; PRESCHOOL CHILD; PRIORITY JOURNAL; QUESTIONNAIRE; RUNNING; SCHOOL CHILD; SLEEP; SOCIAL ADAPTATION; SOUND; SWIMMING;

ADENOSINE; ADOLESCENT; AUTISTIC DISORDER; BEHAVIOR; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; NEUROTRANSMITTER AGENTS; PARENTS; QUESTIONNAIRES;

EID: 79960322947     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.06.007     Document Type: Note

References (50)

1. Ainsworth B.E., Haskell W.L., Whitt M.C., Irwin M.L., Swartz A.M., Strath S.J., O'Brien W.L., Bassett D.R., Schmitz K.H., Emplaincourt P.O., Jacobs D.R., Leon A.S. Compendium of physical activities: an update of activity codes and MET intensities. Med. Sci. Sports Exerc. 2000, 32:S498-S504.
2. Anschel D.J., Ortega E.L., Kraus A.C., Fisher R.S. Focally injected adenosine prevents seizures in the rat. Exp. Neurol. 2004, 190:544-557.
3. Boison D. Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol. Sci. 2006, 27:652-658.
4. D. Boison, S.A. Masino, J.D. Geiger, Homeostatic bioenergetic network regulation: a novel concept to avoid pharmacoresistance in epilepsy, Expert Opin. Drug Discov., doi:10.1517/17460441.2011.575777, in press.
5. Chen F., Lemonnier E., Lazartigues A., Planche P. Sleep problems and information processing, a "disconnection effect" in autism?. Med. Hypotheses 2006, 66:1245-1246.
6. Chez M.G., Chang M., Krasne V., Coughlan C., Kominsky M., Schwartz A. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav. 2006, 8:267-271.
7. Curran L.K., Newschaffer C.J., Lee L.C., Crawford S.O., Johnston M.V., Zimmerman A.W. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 2007, 120:e1386-e1392.
8. Dulla C.G., Dobelis P., Pearson T., Frenguelli B.G., Staley K.J., Masino S.A. Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron 2005, 48:1011-1023.
9. Dulla C.G., Frenguelli B.G., Staley K.J., Masino S.A. Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. J. Neurophysiol. 2009, 102:1984-1993.
10. Dunwiddie T.V., Masino S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 2001, 24:31-55.
11. Dunwiddie T.V., Worth T.S. Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. J. Pharmacol. Exp. Ther. 1982, 220:70-76.
12. Dworak M., Diel P., Voss S., Hollmann W., Struder H.K. Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep drive. Neuroscience 2007, 150:789-795.
13. Edelson S.M., Edelson M.G., Kerr D.C., Grandin T. Behavioral and physiological effects of deep pressure on children with autism: a pilot study evaluating the efficacy of Grandin's Hug Machine. Am. J. Occup. Ther. 1999, 53:145-152.
14. Escalona A., Field T., Singer-Strunck R., Cullen C., Hartshorn K. Brief report: improvements in the behavior of children with autism following massage therapy. J. Autism Dev. Disord. 2001, 31:513-516.
15. Evangeliou A., Vlachonikolis I., Mihailidou H., Spilioti M., Skarpalezou A., Makaronas N., Prokopiou A., Christodoulou P., Liapi-Adamidou G., Helidonis E., Sbyrakis S., Smeitink J. Application of a ketogenic diet in children with autistic behavior: pilot study. J. Child Neurol. 2003, 18:113-118.
16. Fatemi S.H., Folsom T.D., Reutiman T.J., Thuras P.D. Expression of GABAB receptors is altered in brains of subjects with autism. Cerebellum 2009, 8:64-69.
17. Fatemi S.H., Reutiman T.J., Folsom T.D., Thuras P.D. GABAA receptor downregulation in brains of subjects with autism. J. Autism Dev. Disord. 2009, 39:223-230.
18. Franke H., Grummich B., Härtig W., Grosche J., Regenthal R., Edwards R.H., Illes P., Krügel U. Changes in purinergic signaling after cerebral injury - involvement of glutamatergic mechanisms?. Int. J. Dev. Neurosci. 2006, 24:123-132.
19. Franke H., Krügel U., Illes P. P2 receptors and neuronal injury. Pflugers Arch. Eur. J. Physiol. 2006, 452:622-644.
20. Ghanizadeh A. Possible role of caffeine in autism spectrum disorders, a new testable hypothesis. J. Food Sci. 2010, 75:ix.
21. Goldman N., Chen M., Fujita T., Xu Q., Peng W., Liu W., Jensen T.K., Pei Y., Wang F., Han X., Chen J.-F., Schnermann J., Takano T., Bekar L., Tieu K., Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat. Neurosci. 2010, 13:883-888.
22. Haas R.H., Rice M.A., Tauner D.A., Merritt T.A. Therapeutic effects of a ketogenic diet in Rett syndrome. Am. J. Med. Genet. 1986, 1(Suppl.):225-246.
23. Herbert M.R., Russo J.P., Yang S., Roohi J., Blaxill M., Kahler S.G., Cremer L., Hatchwell E. Autism and environmental genomics. Neurotoxicology 2006, 27:671-684.
24. Hussman J.P. Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism. J. Autism Dev. Disord. 2001, 31:247-248.
25. Johansson B., Halldner L., Dunwiddie T.V., Masino S.A., Poelchen W., Giménez-Llort L., Escorihuela L.M., Fernández-Teruel A., Wiesenfeld-Hallin Z., Xu X.-J., Hårdemark A., Betscholtz C., Herlenius E., Fredholm B.B. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:9407-9412.
26. Kawamura M., Ruskin D.N., Masino S.A. Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors and KATP channels. J. Neurosci. 2010, 30:3886-3895.
27. Lara D.R. Caffeine, mental health, and psychiatric disorders. J. Alzheimers Dis. 2010, 20(Suppl. 1):S239-S248.
28. Lee H., Marvin A.R., Watson T., Piggot J., Law J.K., Law P.A., Constantino J.N., Nelson S.F. Accuracy of phenotyping of autistic children based on internet implemented parent report. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2010, 153B:1119-1126.
29. Liss M., Saulnier C., Fein D., Kinsbourne M. Sensory and attention abnormalities in autistic spectrum disorders. Autism 2006, 10:155-172.
30. Malow B.A. Sleep disorders, epilepsy, and autism. Ment. Retard. Dev. Disabil. Res. Rev. 2004, 10:122-125.
31. Mantis J.G., Fritz C.L., Marsh J., Heinrichs S.C., Seyfried T.N. Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets. Epilepsy Behav. 2009, 15:133-141.
32. Masino S.A., Dunwiddie T.V. Temperature-dependent modulation of excitatory transmission in hippocampal slices is mediated by extracellular adenosine. J. Neurosci. 1999, 19:1932-1939.
33. Masino S.A., Kawamura M., Wasser C.D., Pomeroy L.T., Ruskin D.N. Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr. Neuropharmacol. 2009, 7:257-268.
34. Masino S.A., Li T., Theofilas P., Ruskin D.N., Fredholm B.B., Geiger J.D., Aronica E., Boison D. A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. J. Clin. Invest. 2011, 121(7):2679-2683.
35. Muhle R., Trentacoste S.V., Rapin I. The genetics of autism. Pediatrics 2004, 113:e472-e486.
36. Myers S.M., Johnson C.P. Management of children with autism spectrum disorders. Pediatrics 2007, 120:1162-1182.
37. Nyhan W.L., James J.A., Teberg A.J., Sweetman L., Nelson L.G. A new disorder of purine metabolism with behavioral manifestations. J. Pediatr. 1969, 74:20-27.
38. Oswald D.P., Sonenklar N.A. Medication use among children with autism spectrum disorders. J. Child Adolesc. Psychopharmacol. 2007, 17:348-355.
39. Pardo C.A., Eberhart C.G. The neurobiology of autism. Brain Pathol. 2007, 17:434-447.
40. Phillis J.W., Simpson R.E., Walter G.A. The effect of hyperglycemia on extracellular levels of adenosine in the hypoxic rat cerebral cortex. Brain Res. 1990, 524:336-338.
41. Ribeiro J.A., Sebastião A.M. Caffeine and adenosine. J. Alzheimers Dis. 2010, 20(Suppl. 1):S3-S15.
42. Rutter M., Bailey A., Lord C. Social Communication Questionnaire 2003, Western Psychological Services, Los Angeles.
43. Svedova J., DiMario F.J. The ketogenic diet: effects on behavior and temperament in children with epilepsy. Ann. Neurol. 2010, 68(Suppl. 14):S129-S130.
44. Svedova J., Masino S.A., DiMario F.J. Retrospective Analysis of the Effects of the Ketogenic Diet on Behavior and Temperament of Children with Epilepsy 2010, Society for Neuroscience, San Diego, CA, (Abstract 561.6).
45. Tanimura Y., Vaziri S., Lewis M.H. Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonists. Behav. Brain Res. 2010, 210:116-122.
46. Thompson S.M., Haas H.L., Gahwiler B.H. Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. J. Physiol. 1992, 451:347-363.
47. Watters R.G., Watters W.E. Decreasing self-stimulatory behavior with physical exercise in a group of autistic boys. J. Autism Dev. Disord. 1980, 10:379-387.
48. Whitcomb K., Lupica C.R., Rosen J.B., Berman R.F. Adenosine involvement in postictal events in amygdala-kindled rats. Epilepsy Res. 1990, 6:171-179.
49. Wong V.C., Chen W.X. Randomized controlled trial of electro-acupuncture for autism spectrum disorder. Altern. Med. Rev. 2010, 15:136-146.
50. Zhao X., Leotta A., Kustanovich V., Lajonchere C., Geschwind D.H., Law K., Law P., Qiu S., Lord C., Sebat J., Ye K., Wigler M. A unified genetic theory for sporadic and inherited autism. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12831-12836.