-
1
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP, (1996) Enhancement of antitumor immunity by CTLA-4 blockade. Science 271: 1734-1736.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
2
-
-
0036301503
-
CTLA-4: new insights into its biological function and use in tumor immunotherapy
-
Egen JG, Kuhns MS, Allison JP, (2002) CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 3: 611-618.
-
(2002)
Nat Immunol
, vol.3
, pp. 611-618
-
-
Egen, J.G.1
Kuhns, M.S.2
Allison, J.P.3
-
3
-
-
0034194329
-
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
-
Hurwitz AA, Foster BA, Kwon ED, Truong T, Choi EM, et al. (2000) Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 60: 2444-2448.
-
(2000)
Cancer Res
, vol.60
, pp. 2444-2448
-
-
Hurwitz, A.A.1
Foster, B.A.2
Kwon, E.D.3
Truong, T.4
Choi, E.M.5
-
4
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
van Elsas A, Hurwitz AA, Allison JP, (1999) Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 190: 355-366.
-
(1999)
J Exp Med
, vol.190
, pp. 355-366
-
-
van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
5
-
-
77954956787
-
Current experience with CTLA4-blocking monoclonal antibodies for the treatment of solid tumors
-
Agarwala SS, Ribas A, (2010) Current experience with CTLA4-blocking monoclonal antibodies for the treatment of solid tumors. J Immunother 33: 557-569.
-
(2010)
J Immunother
, vol.33
, pp. 557-569
-
-
Agarwala, S.S.1
Ribas, A.2
-
6
-
-
61449090474
-
Phase I/II trial of tremelimumab in patients with metastatic melanoma
-
Camacho LH, Antonia S, Sosman J, Kirkwood JM, Gajewski TF, et al. (2009) Phase I/II trial of tremelimumab in patients with metastatic melanoma. J Clin Oncol 27: 1075-1081.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1075-1081
-
-
Camacho, L.H.1
Antonia, S.2
Sosman, J.3
Kirkwood, J.M.4
Gajewski, T.F.5
-
7
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, et al. (2005) Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 23: 6043-6053.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
Robinson, M.R.4
Quezado, M.M.5
-
8
-
-
78651364767
-
Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells
-
Khan S, Burt DJ, Ralph C, Thistlethwaite FC, Hawkins RE, et al. (2011) Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells. Clin Immunol 138: 85-96.
-
(2011)
Clin Immunol
, vol.138
, pp. 85-96
-
-
Khan, S.1
Burt, D.J.2
Ralph, C.3
Thistlethwaite, F.C.4
Hawkins, R.E.5
-
9
-
-
51349165526
-
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion
-
Kavanagh B, O'Brien S, Lee D, Hou Y, Weinberg V, et al. (2008) CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion. Blood 112: 1175-1183.
-
(2008)
Blood
, vol.112
, pp. 1175-1183
-
-
Kavanagh, B.1
O'Brien, S.2
Lee, D.3
Hou, Y.4
Weinberg, V.5
-
10
-
-
31644432589
-
Regulatory T cells in immune surveillance and treatment of cancer
-
Yamaguchi T, Sakaguchi S, (2006) Regulatory T cells in immune surveillance and treatment of cancer. Semin Cancer Biol 16: 115-123.
-
(2006)
Semin Cancer Biol
, vol.16
, pp. 115-123
-
-
Yamaguchi, T.1
Sakaguchi, S.2
-
11
-
-
25844517914
-
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
-
Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, et al. (2005) Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med 202: 885-891.
-
(2005)
J Exp Med
, vol.202
, pp. 885-891
-
-
Ko, K.1
Yamazaki, S.2
Nakamura, K.3
Nishioka, T.4
Hirota, K.5
-
12
-
-
0036170938
-
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
-
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S, (2002) Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nature Immunol 3: 135-142.
-
(2002)
Nature Immunol
, vol.3
, pp. 135-142
-
-
Shimizu, J.1
Yamazaki, S.2
Takahashi, T.3
Ishida, Y.4
Sakaguchi, S.5
-
13
-
-
0033571105
-
Induction of tumor immunity by removing CD25+CD4+ T cells: a acommon basis between tumor immunity and autoimmunity
-
Shimizu J, Yamazaki S, Sakaguchi M, (1999) Induction of tumor immunity by removing CD25+CD4+ T cells: a acommon basis between tumor immunity and autoimmunity. J Immunol 163: 5211-5218.
-
(1999)
J Immunol
, vol.163
, pp. 5211-5218
-
-
Shimizu, J.1
Yamazaki, S.2
Sakaguchi, M.3
-
14
-
-
33750303398
-
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens
-
Lu H, Knutson KL, Gad E, Disis ML, (2006) The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens. Cancer Res 66: 9754-9761.
-
(2006)
Cancer Res
, vol.66
, pp. 9754-9761
-
-
Lu, H.1
Knutson, K.L.2
Gad, E.3
Disis, M.L.4
-
15
-
-
0842282556
-
Neu antigen-negative variants can be generated aftaer neu-specific antibody therapy in neu transgenic mice
-
Knutson KL, Almand B, Dang Y, Disis ML, (2004) Neu antigen-negative variants can be generated aftaer neu-specific antibody therapy in neu transgenic mice. Cancer Res 64: 1146-1151.
-
(2004)
Cancer Res
, vol.64
, pp. 1146-1151
-
-
Knutson, K.L.1
Almand, B.2
Dang, Y.3
Disis, M.L.4
-
16
-
-
34250871751
-
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses
-
Tuve S, Chen BM, Liu Y, Cheng TL, Toure P, et al. (2007) Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses. Cancer Res 67: 5929-5939.
-
(2007)
Cancer Res
, vol.67
, pp. 5929-5939
-
-
Tuve, S.1
Chen, B.M.2
Liu, Y.3
Cheng, T.L.4
Toure, P.5
-
17
-
-
0035251546
-
Development and applications of surface-linked single chain antibodies against T-cell antigens
-
Griffin MD, Holman PO, Tang Q, Ashourian N, Korthauer U, et al. (2001) Development and applications of surface-linked single chain antibodies against T-cell antigens. J Immunol Methods 248: 77-90.
-
(2001)
J Immunol Methods
, vol.248
, pp. 77-90
-
-
Griffin, M.D.1
Holman, P.O.2
Tang, Q.3
Ashourian, N.4
Korthauer, U.5
-
18
-
-
31744445721
-
A versatile tool for conditional gene expression and knockdown
-
Szulc J, Wiznerowicz M, Sauvain MO, Trono D, Aebischer P, (2006) A versatile tool for conditional gene expression and knockdown. Nat Methods 3: 109-116.
-
(2006)
Nat Methods
, vol.3
, pp. 109-116
-
-
Szulc, J.1
Wiznerowicz, M.2
Sauvain, M.O.3
Trono, D.4
Aebischer, P.5
-
19
-
-
29744454288
-
Successful correction of the human Cooley's anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator
-
Malik P, Arumugam PI, Yee JK, Puthenveetil G, (2005) Successful correction of the human Cooley's anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator. Ann N Y Acad Sci 1054: 238-249.
-
(2005)
Ann N Y Acad Sci
, vol.1054
, pp. 238-249
-
-
Malik, P.1
Arumugam, P.I.2
Yee, J.K.3
Puthenveetil, G.4
-
20
-
-
67049164937
-
Toward a stem cell gene therapy for breast cancer
-
Li Z, Liu Y, Tuve S, Xun Y, Fan X, et al. (2009) Toward a stem cell gene therapy for breast cancer. Blood 113: 5423-5433.
-
(2009)
Blood
, vol.113
, pp. 5423-5433
-
-
Li, Z.1
Liu, Y.2
Tuve, S.3
Xun, Y.4
Fan, X.5
-
21
-
-
33746215279
-
Immunoediting of cancers may lead to epithelial to mesenchymal transition
-
Knutson KL, Lu H, Stone B, Reiman JM, Behrens MD, et al. (2006) Immunoediting of cancers may lead to epithelial to mesenchymal transition. J Immunol 177: 1526-1533.
-
(2006)
J Immunol
, vol.177
, pp. 1526-1533
-
-
Knutson, K.L.1
Lu, H.2
Stone, B.3
Reiman, J.M.4
Behrens, M.D.5
-
22
-
-
33745306869
-
IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice
-
Knutson KL, Dang Y, Lu H, Lukas J, Almand B, et al. (2006) IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice. J Immunol 177: 84-91.
-
(2006)
J Immunol
, vol.177
, pp. 84-91
-
-
Knutson, K.L.1
Dang, Y.2
Lu, H.3
Lukas, J.4
Almand, B.5
-
23
-
-
47749147747
-
Biodistribution and safety profile of recombinant adeno-associated virus serotype 6 vectors following intravenous delivery
-
Stone D, Liu Y, Li ZY, Strauss R, Finn EE, et al. (2008) Biodistribution and safety profile of recombinant adeno-associated virus serotype 6 vectors following intravenous delivery. J Virol 82: 7711-7715.
-
(2008)
J Virol
, vol.82
, pp. 7711-7715
-
-
Stone, D.1
Liu, Y.2
Li, Z.Y.3
Strauss, R.4
Finn, E.E.5
-
24
-
-
33749132564
-
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
-
Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, et al. (2006) Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 177: 4376-4383.
-
(2006)
J Immunol
, vol.177
, pp. 4376-4383
-
-
Read, S.1
Greenwald, R.2
Izcue, A.3
Robinson, N.4
Mandelbrot, D.5
-
25
-
-
33745851479
-
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
-
Quezada SA, Peggs KS, Curran MA, Allison JP, (2006) CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 116: 1935-1945.
-
(2006)
J Clin Invest
, vol.116
, pp. 1935-1945
-
-
Quezada, S.A.1
Peggs, K.S.2
Curran, M.A.3
Allison, J.P.4
-
26
-
-
70149123492
-
Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes
-
Shieh SJ, Chou FC, Yu PN, Lin WC, Chang DM, et al. (2009) Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes. J Immunol 183: 2277-2285.
-
(2009)
J Immunol
, vol.183
, pp. 2277-2285
-
-
Shieh, S.J.1
Chou, F.C.2
Yu, P.N.3
Lin, W.C.4
Chang, D.M.5
-
27
-
-
0034255145
-
A chromatin insulator protects retrovirus vectors from chromosomal position effects
-
Emery DW, Yannaki E, Tubb J, Stamatoyannopoulos G, (2000) A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc Natl Acad Sci U S A 97: 9150-9155.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 9150-9155
-
-
Emery, D.W.1
Yannaki, E.2
Tubb, J.3
Stamatoyannopoulos, G.4
-
28
-
-
37249055565
-
The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus
-
Li CL, Emery DW, (2008) The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus. Gene Ther 15: 49-53.
-
(2008)
Gene Ther
, vol.15
, pp. 49-53
-
-
Li, C.L.1
Emery, D.W.2
-
29
-
-
67449164596
-
Epithelial phenotype of ovarian cancer mediates resistance to oncolytic adenoviruses
-
Strauss R, Sova P, Liu Y, Li Z-Y, Tuve S, et al. (2009) Epithelial phenotype of ovarian cancer mediates resistance to oncolytic adenoviruses. Cancer Research 15: 5115-5125.
-
(2009)
Cancer Research
, vol.15
, pp. 5115-5125
-
-
Strauss, R.1
Sova, P.2
Liu, Y.3
Li, Z.-Y.4
Tuve, S.5
-
30
-
-
70349923535
-
Anatomical and physical barriers to tumor targeting with oncolytic adenoviruses in vivo
-
Strauss R, Lieber A, (2009) Anatomical and physical barriers to tumor targeting with oncolytic adenoviruses in vivo. Curr Opin Mol Ther 11: 513-522.
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 513-522
-
-
Strauss, R.1
Lieber, A.2
-
31
-
-
79951841819
-
Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
-
Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F, 3rd, (2011) Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29: 11-19.
-
(2011)
Stem Cells
, vol.29
, pp. 11-19
-
-
Klopp, A.H.1
Gupta, A.2
Spaeth, E.3
Andreeff, M.4
Marini 3rd, F.5
-
32
-
-
68949150545
-
Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?
-
De Palma M, Naldini L, (2009) Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy? Biochim Biophys Acta 1796: 5-10.
-
(2009)
Biochim Biophys Acta
, vol.1796
, pp. 5-10
-
-
de Palma, M.1
Naldini, L.2
-
33
-
-
79952188081
-
Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab
-
Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, et al. (2011) Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab. Mol Ther 19: 479-489.
-
(2011)
Mol Ther
, vol.19
, pp. 479-489
-
-
Beyer, I.1
Li, Z.2
Persson, J.3
Liu, Y.4
van Rensburg, R.5
-
34
-
-
1542511203
-
NKT cells: what's in a name?
-
Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L, (2004) NKT cells: what's in a name? Nat Rev Immunol 4: 231-237.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 231-237
-
-
Godfrey, D.I.1
MacDonald, H.R.2
Kronenberg, M.3
Smyth, M.J.4
van Kaer, L.5
-
35
-
-
77954521483
-
Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells
-
Hegde S, Fox L, Wang X, Gumperz JE, (2010) Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells. Immunology 130: 471-483.
-
(2010)
Immunology
, vol.130
, pp. 471-483
-
-
Hegde, S.1
Fox, L.2
Wang, X.3
Gumperz, J.E.4
-
36
-
-
77956194304
-
CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses
-
Teige A, Bockermann R, Hasan M, Olofsson KE, Liu Y, et al. (2010) CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses. J Immunol 185: 345-356.
-
(2010)
J Immunol
, vol.185
, pp. 345-356
-
-
Teige, A.1
Bockermann, R.2
Hasan, M.3
Olofsson, K.E.4
Liu, Y.5
-
37
-
-
56849090964
-
The role of NKT cells in tumor immunity
-
Terabe M, Berzofsky JA, (2008) The role of NKT cells in tumor immunity. Adv Cancer Res 101: 277-348.
-
(2008)
Adv Cancer Res
, vol.101
, pp. 277-348
-
-
Terabe, M.1
Berzofsky, J.A.2
-
38
-
-
48449086316
-
TGF-beta: a master of all T cell trades
-
Li MO, Flavell RA, (2008) TGF-beta: a master of all T cell trades. Cell 134: 392-404.
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
39
-
-
67349185829
-
In situ adenovirus vaccination engages T effector cells against cancer
-
Tuve S, Liu Y, Tragoolpua K, Jacobs JD, Yumul RC, et al. (2009) In situ adenovirus vaccination engages T effector cells against cancer. Vaccine 27: 4225-4239.
-
(2009)
Vaccine
, vol.27
, pp. 4225-4239
-
-
Tuve, S.1
Liu, Y.2
Tragoolpua, K.3
Jacobs, J.D.4
Yumul, R.C.5
-
40
-
-
85063072480
-
Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab
-
Mol Ther
-
Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, et al. (2010) Controlled Extracellular Matrix Degradation in Breast Cancer Tumors Improves Therapy by Trastuzumab. Mol Ther.
-
(2010)
-
-
Beyer, I.1
Li, Z.2
Persson, J.3
Liu, Y.4
van Rensburg, R.5
-
41
-
-
77949327636
-
Recruitment and differentiation of conventional dendritic cell precursors in tumors
-
Diao J, Zhao J, Winter E, Cattral MS, (2010) Recruitment and differentiation of conventional dendritic cell precursors in tumors. J Immunol 184: 1261-1267.
-
(2010)
J Immunol
, vol.184
, pp. 1261-1267
-
-
Diao, J.1
Zhao, J.2
Winter, E.3
Cattral, M.S.4
-
42
-
-
39149138136
-
A macrophage gene expression signature defines a field effect in the lung tumor microenvironment
-
Stearman RS, Dwyer-Nield L, Grady MC, Malkinson AM, Geraci MW, (2008) A macrophage gene expression signature defines a field effect in the lung tumor microenvironment. Cancer Res 68: 34-43.
-
(2008)
Cancer Res
, vol.68
, pp. 34-43
-
-
Stearman, R.S.1
Dwyer-Nield, L.2
Grady, M.C.3
Malkinson, A.M.4
Geraci, M.W.5
-
43
-
-
34248140839
-
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects
-
Aker M, Tubb J, Groth AC, Bukovsky AA, Bell AC, et al. (2007) Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects. Hum Gene Ther 18: 333-343.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 333-343
-
-
Aker, M.1
Tubb, J.2
Groth, A.C.3
Bukovsky, A.A.4
Bell, A.C.5
|