FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain

Biochemical and Biophysical Research Communications

Volumn 410, Issue 4, 2011, Pages 744-748

  Terada, Tomoyoshi ^a,b   Nunomura, Satoshi ^a   Shimokawa, Toshibumi ^a   Murayama, Koichi ^b   Era, Seiichi ^b   Kondo, Naomi ^b   Ra, Chisei ^a  

^a NIHON UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Degranulation; Fc RI ; IL 6; Mast cells

Indexed keywords

ALANINE; ASPARTIC ACID; CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN E FC RECEPTOR BETA; INTERLEUKIN 6; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CYTOKINE PRODUCTION; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; MAST CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; CYTOKINES; MAST CELLS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IGE;

EID: 79960290709     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.030     Document Type: Article

References (26)

1. Metcalfe D.D., Baram D., Mekori Y.A. Mast cells. Physiol. Rev. 1997, 77:1033-1079.
2. Blank U., Ra C., Miller L., White K., Metzger H., Kinet J.P. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 1989, 337:187-189.
3. Kinet J.P., Blank U., Ra C., White K., Metzger H., Kochan J. Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc. Natl. Acad. Sci. USA 1988, 85:6483-6487.
4. Ra C., Jouvin M.H., Kinet J.P. Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J. Biol. Chem. 1989, 264:15323-15327.
5. Eiseman E., Bolen J.B. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 1992, 355:78-80.
6. Irving B.A., Chan A.C., Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J. Exp. Med. 1993, 177:1093-1103.
7. Letourneur F., Klausner R.D. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 1992, 255:79-82.
8. Scharenberg A.M., Lin S., Cuenod B., Yamamura H., Kinet J.P. Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J. 1995, 14:3385-3394.
9. Letourneur F., Klausner R.D. T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc. Natl. Acad. Sci. USA 1991, 88:8905-8909.
10. Jouvin M.H., Adamczewski M., Numerof R., Letourneur O., Valle A., Kinet J.P. Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor. J. Biol. Chem. 1994, 269:5918-5925.
11. Lin S., Cicala C., Scharenberg A.M., Kinet J.P. The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals. Cell 1996, 85:985-995.
12. Dombrowicz D., Lin S., Flamand V., Brini A.T., Koller B.H., Kinet J.P. Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity 1998, 8:517-529.
13. Furumoto Y., Nunomura S., Terada T., Rivera J., Ra C. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J. Biol. Chem. 2004, 279:49177-49187.
14. On M., Billingsley J.M., Jouvin M.H., Kinet J.P. Molecular dissection of the FcRbeta signaling amplifier. J. Biol. Chem. 2004, 279:45782-45790.
15. Tsukamoto T., Huang T., Guzman R.C., Chen X., Pascual R.V., Kitamura T., Nandi S. Isolation of oncogenes from rat mammary tumors by a highly efficient retrovirus expression cloning system. Biochem. Biophys. Res. Commun. 1999, 265:7-12.
16. Hiraoka S., Furumoto Y., Koseki H., Takagaki Y., Taniguchi M., Okumura K., Ra C. Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. Int. Immunol. 1999, 11:199-207.
17. Furumoto Y., Hiraoka S., Kawamoto K., Masaki S., Kitamura T., Okumura K., Ra C. Polymorphisms in FcepsilonRI beta chain do not affect IgE-mediated mast cell activation. Biochem. Biophys. Res. Commun. 2000, 273:765-771.
18. Rivera J., Kinet J.P., Kim J., Pucillo C., Metzger H. Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E. Mol. Immunol. 1988, 25:647-661.
19. George J., Kubarenko A.V., Rautanen A., et al. MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP. J. Immunol. 2010, 184:3025-3032.
20. Marquardt D.L., Walker L.L. Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity. J. Allergy Clin. Immunol. 2000, 105:500-505.
21. Hepp R., Puri N., Hohenstein A.C., Crawford G.L., Whiteheart S.W., Roche P.A. Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J. Biol. Chem. 2005, 280:6610-6620.
22. Suzuki K., Verma I.M. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 2008, 134:485-495.
23. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 2009, 27:693-733.
24. Schulze-Luehrmann J., Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006, 25:701-715.
25. Weil R., Israel A. T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes. Curr. Opin. Immunol. 2004, 16:374-381.
26. Klemm S., Gutermuth J., Hultner L., et al. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J. Exp. Med. 2006, 203:337-347.