Molecular epidemiology of malaria in Cameroon. XXX. Sequence analysis of Plasmodium falciparum ATPase 6, dihydrofolate reductase, and dihydropteroate synthase resistance markers in clinical isolates from children treated with an artesunate-sulfadoxine-pyrimethamine combination

American Journal of Tropical Medicine and Hygiene

Volumn 85, Issue 1, 2011, Pages 22-25

  Menemedengue, Virginie ^a,b   Sahnouni, Khalifa ^a   Basco, Leonardo ^a   Tahar, Rachida ^a  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^b UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 6; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; PYRIMETHAMINE PLUS SULFADOXINE; QUININE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CAMEROON; CHILD; CLINICAL EFFECTIVENESS; DRUG EFFICACY; ENZYME ISOLATION; GENE MUTATION; HUMAN; MALARIA; MOLECULAR EPIDEMIOLOGY; PLASMODIUM FALCIPARUM; SEQUENCE ANALYSIS; SINGLE DRUG DOSE; WILD TYPE;

ANTIMALARIALS; ARTEMISININS; CAMEROON; CHILD; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MOLECULAR EPIDEMIOLOGY; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE;

ARTESUNATE; PLASMODIUM FALCIPARUM;

EID: 79960285881     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2011.10-0523     Document Type: Article

References (20)

1. World Health Organization, 2005. Susceptibility of Plasmodium falciparum to Antimalarial Drugs. Report on Global Monitoring 1996-2004: Geneva: World Health Organization.
2. Dondorp AM, Yeung S, White L, Nguon C, Day NP, Socheat D, von Seidlein L, 2010. Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol 8: 272-280.
3. Krishna S, Pulcini S, Fatih F, Staines H, 2010. Artemisinins and the biological basis for the PfATP6/SERCA hypothesis. Trends Parasitol 26: 517-523.
4. Uhlemann AC, Cameron A, Eckstein-Ludwig U, Fischbarg J, Iserovich P, Zuniga FA, East M, Lee A, Brady L, Haynes RK, Krishna S, 2005. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol 12: 628-629. (Pubitemid 40980816)
5. Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney B, Ekala MT, Bouchier C, Esterre P, Fandeur T, Mercereau-Puijalon O, 2005. Resistance of Plasmodium falciparum field isolates to invitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366: 1960-1963. (Pubitemid 41713986)
6. Witkowski B, Lelièvre J, Lopez Barragan MJ, Laurent V, Su XZ, Berry A, Benoit-Vical F, 2010. Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob Agents Chemother 54: 1872-1877.
7. Pearce RJ, Pota H, Evehe MSB, Ba EH, Mombo-Ngoma G, Malisa AL, Ord R, Inojosa W, Matondo A, Diallo DA, Mbacham W, van den Broek IV, Swarthout TD, Getachew A, Dejene S, Grobusch MP, Njie F, Dunyo S, Kweku M, Owusu-Agyei S, Chandramohan D, Bonnet M, Guthmann JP, Clarke S, Barnes KI, Streat E, Katokele ST, Uusiku P, Agboghoroma CO, Elegba OY, Cisse B, A-Elbasit IE, Giha HA, Kachur SP, Lynch C, Rwakimari JB, Chanda P, Hawela M, Sharp B, Naidoo I, Roper C, 2009. Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PLoS Med 6: e1000055.
8. Whegang SY, Tahar R, Foumane VN, Soula G, Gwet H, Thalabard JC, Basco LK, 2010. Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated malaria in Cameroon. Malar J 9: 56. Available at: http://www.malariajournal.com/content/9/1/56.
9. World Health Organization, 2003. Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated falciparum Malaria. Geneva: World Health Organization, WHO/HTM/RBM/2003.50.
10. World Health Organization, 2008. Methods and Techniques for Clinical Trials on Antimalarial Drug Efficacy: Genotyping to Identify Parasite Populations. Informal Consultation Organized by the Medicines for Malaria Venture and Cosponsored by the World Health Organization, May 29-31, 2007, Amsterdam, The Netherlands.
11. Eldin de Pécoulas P, Basco LK, Abdallah B, Djé MK, Le Bras J, Mazabraud A, 1995. Plasmodium falciparum: detection of anti-folate resistance by mutation-specific restriction enzyme digestion. Exp Parasitol 80: 483-487.
12. Duraisingh MT, Curtis J, Warhurst DC, 1998. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol 89: 1-8. (Pubitemid 28377366)
13. Tahar R, Ringwald P, Basco LK, 2009. Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene. Am J Trop Med Hyg 81: 13-18.
14. Tahar R, Basco LK, 2007. Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodiumfalciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children. Acta Trop 103: 81-89. (Pubitemid 47277439)
15. Mugittu K, Genton B, Mshinda H, Beck HP, 2006. Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. Malar J 5: 126. Available at: http://www.malariajournal.com/content/5/1/126.
16. 2+-ATPase orthologue of Plasmodium falciparum (PfATP6) . Infect Genet Evol 8: 340-345.
17. Menegon M, Sannella AR, Majori G, Severini C, 2008. Detection of novel point mutations in the Plasmodium falciparum ATPase 6 candidate gene for resistance to artemisinins. Parasitol Int 57: 233-235.
18. Zhang GQ, Guan Y, Zheng B, Wu S, Tang LH, 2008. No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China. Malar J 7: 122. Available at: http://www.malariajournal.com/content/7/1/112.
19. Ibrahim ML, Khim N, Adam HH, Ariey F, Duchemin JB, 2009. Polymorphism of PfATPase in Niger: detection of three new point mutations. Malar J 8: 28. Available at: http://www.malariajournal.com/content/8/1/28.
20. Cojean S, Hubert V, Le Bras J, Durand R, 2006. Resistance to dihydroartemisinin. Emerg Infect Dis 12: 1798-1799.