Tumor budding is predictive of lymphatic involvement and lymph node metastases in submucosal invasive colorectal adenocarcinomas and in non-polypoid compared with polypoid growths

Scandinavian Journal of Gastroenterology

Volumn 44, Issue 5, 2009, Pages 605-614

  Ogawa, Taishi ^a,b,c   Yoshida, Tsutomu ^a   Tsuruta, Tomoko ^a   Tokuyama, Wataru ^a   Adachi, Shigeru ^a,b   Kikuchi, Masaomi ^a,b   Mikami, Tetuo ^a   Saigenji, Katsunori ^b   Okayasu, Isao ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c CANCER INSTITUTE HOSPITAL   (Japan)

Author keywords

Colorectal carcinoma; Lymphatic involvement; Non polypoid growth; Polypoid growth; Tumor budding

Indexed keywords

BETA CATENIN; KALININ;

ADENOCARCINOMA; ADULT; ARTICLE; CANCER GROWTH; CELL STRUCTURE; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENETIC STABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; AGED; CANCER INVASION; CANCER STAGING; COLON POLYP; COLORECTAL TUMOR; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DISEASE COURSE; FOLLOW UP; INTESTINE MUCOSA; LYMPH NODE; LYMPHADENECTOMY; METASTASIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEEDLE BIOPSY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; PROBABILITY; REGISTER; RETROSPECTIVE STUDY; RISK; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TUMOR VOLUME;

ADENOCARCINOMA; AGED; BIOPSY, NEEDLE; COLONIC POLYPS; COLORECTAL NEOPLASMS; CONFIDENCE INTERVALS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; LOGISTIC MODELS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROBABILITY; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TUMOR BURDEN;

EID: 67651120152     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520902718911     Document Type: Article

References (23)

1. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
2. Kuramoto S, Oohara T. Flat early cancers of the large intestine. Cancer 1989;64:950-5.
3. Shimoda T, Ikegami M, Fujisaki J, Matsui T, Aizawa S, Ishikawa E. Early colorectal carcinoma with special reference to its development de novo. Cancer 1989;64:1138-46.
4. Clevers H. Wnt/β-catenin signaling in development and disease. Cell 2006;127:469-80.
5. Horkko TT, Klintrup K, Makinen JM, Napankangas JB, Tuominen HJ, Makela J, et al. Budding invasive margin and prognosis in colorectal cancer: no direct association with P-catenin expression. Eur J Cancer 2006;42:964-71.
6. Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T. Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin. Cancer Res 2001;61: 8089-93.
7. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene 2005;24:7443-54.
8. Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A. Autoregulation of e-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, slug, and mapk. J Cell Biol 2003;163: 847-57.
9. Kazama S, Watanabe T, Ajioka Y, Kanazawa T, Nagawa H. Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 2006;94:293-8.
10. Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum 1993;36:627-35.
11. Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC. Tumour "budding" as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002;40: 127-32.
12. Ueno H, Mochizuki H, Hashiguchi Y, Shimazaki H, Aida S, Hase K, et al. Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology 2004;127: 385-94.
13. Shinto E, Mochizuki H, Ueno H, Matsubara O, Jass JR. A novel classification of tumor budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology 2005;47:25-31.
14. Kitajima K, Fujimori T, Fujii S, Takeda J, Ohkura Y, Kawamata H, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: A Japanese collaborative study. J Gastroenterol 2004;39:534-43.
15. Ogawa T, Yoshida T, Tsuruta T, Saigenji K, Okayasu I. Genetic instability on chromosome 17 in the epithelium of non-polypoid colorectal carcinomas compared to polypoid lesions. Cancer Sci 2006;97:1335-42.
16. Yoshida T, Mikami T, Mitomi H, Okayasu I. Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts. J Pathol 2003;199:166-75.
17. Shinto E, Baker K, Tsuda H, Mochizuki H, Ueno H, Matsubara O, et al. Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer. Dis Colon Rectum 2006;49:1193-202.
18. Japanese Society for Cancer of the Colon and Rectum. Histological findings. Japanese classification of colorectal carcinoma, first ed. [English]. Tokyo: Kanehara & Co; 1997. p 34.
19. Kudo S, Tamura S, Hirota S, Sano Y, Yamono H, Serizawa M, et al. The problem of de novo colorectal carcinoma. Eur J Cancer 1995;31A:1118-20.
20. Tung SY, Wu CS, Wu MC, Su MY. Endoscopic treatment of colorectal polyps and early cancer. Dig Dis Sci 2001;46: 1152-6.
21. Nivatvongs S. Surgical management of early colorectal cancer. World J Surg 2000;24:1052-5.
22. Egashira Y, Yoshida T, Hirata I, Hamamoto N, Akutagawa H, Takeshita A, et al. Analysis of pathological risk factors for lymph node metastasis of submucosal invasive colon cancer. Mod Pathol 2004;17:503-11.
23. Miyazaki K. Laminin-5 (laminin-332): unique biological activity and role in tumor growth and invasion. Cancer Sci 2006;97:91-8.