The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata

FEMS Yeast Research

Volumn 11, Issue 5, 2011, Pages 449-456

  Miyazaki, Taiga ^a   Izumikawa, Koichi ^a   Yamauchi, Shunsuke ^a   Inamine, Tatsuo ^b   Nagayoshi, Yohsuke ^a   Saijo, Tomomi ^a   Seki, Masafumi ^a   Kakeya, Hiroshi ^a   Yamamoto, Yoshihiro ^a   Yanagihara, Katsunori ^a   Miyazaki, Yoshitsugu ^c   Yasuoka, Akira ^d   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d NAGASAKI UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cell wall integrity; Mpk1; Yapsin

Indexed keywords

ASPARTIC PROTEINASE; BETA GALACTOSIDASE; CALCINEURIN; GLYCOSYLPHOSPHATIDYLINOSITOL; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CRZ1; PROTEIN SLT2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; YAPSIN 1;

ARTICLE; CANDIDA GLABRATA; CELL GROWTH; CELL WALL; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL GENE; FUNGAL GENOME; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE DELETION; GENE EXPRESSION; HIGH TEMPERATURE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; SIGNAL TRANSDUCTION; TEMPERATURE SENSITIVITY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ASPARTIC ACID PROTEASES; BETA-GALACTOSIDASE; CALCINEURIN; CANDIDA GLABRATA; CANDIDIASIS; CELL WALL; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENETIC COMPLEMENTATION TEST; GLYCOSYLPHOSPHATIDYLINOSITOLS; HOT TEMPERATURE; MUTATION; PROMOTER REGIONS, GENETIC; RNA, FUNGAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VIRULENCE;

CANDIDA GLABRATA; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 79960261341     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2011.00734.x     Document Type: Article

References (20)

1. Boeke JD, LaCroute F & Fink GR (1984) A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197: 345-346.
2. Cormack BP & Falkow S (1999) Efficient homologous and illegitimate recombination in the opportunistic yeast pathogen Candida glabrata. Genetics 151: 979-987.
3. Dujon B, Sherman D, Fischer G et al. (2004) Genome evolution in yeasts. Nature 430: 35-44.
4. El Barkani A, Haynes K, Mosch H, Frosch M & Muhlschlegel FA (2000) Candida glabrata shuttle vectors suitable for translational fusions to lacZ and use of beta-galactosidase as a reporter of gene expression. Gene 246: 151-155.
5. Frieman MB, McCaffery JM & Cormack BP (2002) Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1, 6 glucan-cross-linked cell wall protein. Mol Microbiol 46: 479-492.
6. Gagnon-Arsenault I, Tremblay J & Bourbonnais Y (2006) Fungal yapsins and cell wall: a unique family of aspartic peptidases for a distinctive cellular function. FEMS Yeast Res 6: 966-978.
7. Garcia R, Bermejo C, Grau C et al. (2004) The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. J Biol Chem 279: 15183-15195.
8. Kaiser C, Michaelis S & Mitchell A (1994) Laboratory Course Manual for Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
9. Kaur R, Ma B & Cormack BP (2007) A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata. P Natl Acad Sci USA 104: 7628-7633.
10. Kitada K, Yamaguchi E & Arisawa M (1995) Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation. Gene 165: 203-206.
11. Kitada K, Yamaguchi E & Arisawa M (1996) Isolation of a Candida glabrata centromere and its use in construction of plasmid vectors. Gene 175: 105-108.
12. Krysan DJ, Ting EL, Abeijon C, Kroos L & Fuller RS (2005) Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Eukaryot Cell 4: 1364-1374.
13. Miller JH (1972) Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
14. Miyazaki T, Inamine T, Yamauchi S et al. (2010a) Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata. FEMS Yeast Res 10: 343-352.
15. Miyazaki T, Yamauchi S, Inamine T et al. (2010b) Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata. Antimicrob Agents Ch 54: 1639-1643.
16. Proft M & Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9: 1307-1317.
17. Proft M, Pascual-Ahuir A, de Nadal E, Arino J, Serrano R & Posas F (2001) Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. EMBO J 20: 1123-1133.
18. Proft M, Gibbons FD, Copeland M, Roth FP & Struhl K (2005) Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell 4: 1343-1352.
19. Saijo T, Miyazaki T, Izumikawa K et al. (2010) Skn7p is involved in oxidative stress response and virulence of Candida glabrata. Mycopathologia 169: 81-90.
20. Yoshimoto H, Saltsman K, Gasch AP et al. (2002) Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae. J Biol Chem 277: 31079-31088.