Challenges in the use of NG2 antigen as a marker to predict MLL rearrangements in multi-center studies

Leukemia Research

Volumn 35, Issue 8, 2011, Pages 1001-1007

  Emerenciano, Mariana ^a   Renaud, Gabriel ^a   Sant'Ana, Mariana ^a   Barbieri, Caroline ^a   Passetti, Fabio ^a   Pombo de Oliveira, Maria S ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

Acute lymphoblastic leukemia; Acute myeloid leukemia; Immunophenotype; Infant leukemia; MLL; NG2

Indexed keywords

ANTIGEN; NG2 ANTIGEN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BRAZIL; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; GENE; GENE REARRANGEMENT; HUMAN; INFANT; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MLL GENE; PREDICTION; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANTIGENS; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOPHENOTYPING; INFANT; INFANT, NEWBORN; LEUKEMIA, MYELOID, ACUTE; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROTEOGLYCANS; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 79960255862     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.03.006     Document Type: Article

References (23)

1. Biondi A., Cimino G., Pieters R., Pui C.H. Biological and therapeutic aspects of infant leukemia. Blood 2000, 96:24-33.
2. Meyer C., Kowarz E., Hofmann J., Renneville A., Zuna J., Trka J., et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009.
3. Pieters R., Schrappe M., De L.P., Hann I., De R.G., Felice M., et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet 2007, 370:240-250.
4. Bueno C., Catalina P., Melen G.J., Montes R., Sanchez L., Ligero G., et al. Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells. Carcinogenesis 2009, 30:1628-1637.
5. Emerenciano M., Agudelo Arias D.P., Coser V.M., de Brito G.D., Macedo Silva M.L., Pombo-de-Oliveira M.S. Molecular cytogenetic findings of acute leukemia included in the Brazilian collaborative study group of infant acute leukemia. Pediatr Blood Cancer 2006, 47:549-554.
6. Menendez P., Catalina P., Rodriguez R., Melen G.J., Bueno C., Arriero M., et al. Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene. J Exp Med 2009, 206:3131-3141.
7. Meyer C., Schneider B., Reichel M., Angermueller S., Strehl S., Schnittger S., et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci U S A 2005, 102:449-454.
8. van Dongen J.J., Macintyre E.A., Gabert J.A., Delabesse E., Rossi V., Saglio G., et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 1999, 13:1901-1928.
9. Behm F.G., Smith F.O., Raimondi S.C., Pui C.H., Bernstein I.D. Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7. 1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. Blood 1996, 87:1134-1139.
10. Hilden J.M., Smith F.O., Frestedt J.L., McGlennen R., Howells W.B., Sorensen P.H., et al. MLL gene rearrangement, cytogenetic 11q23 abnormalities, and expression of the NG2 molecule in infant acute myeloid leukemia. Blood 1997, 89:3801-3805.
11. Smith F.O., Rauch C., Williams D.E., March C.J., Arthur D., Hilden J., et al. The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23. Blood 1996, 87:1123-1133.
12. Wuchter C., Harbott J., Schoch C., Schnittger S., Borkhardt A., Karawajew L., et al. Detection of acute leukemia cells with mixed lineage leukemia (MLL) gene rearrangements by flow cytometry using monoclonal antibody 7.1. Leukemia 2000, 14:1232-1238.
13. Bueno C., Montes R., Martin L., Prat I., Hernandez M.C., Orfao A., et al. NG2 antigen is expressed in CD34+ HPCs and plasmacytoid dendritic cell precursors: is NG2 expression in leukemia dependent on the target cell where leukemogenesis is triggered?. Leukemia 2008, 22:1475-1478.
14. Bueno C., Montes R., Catalina P., Rodriguez R., Menendez P. Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement. Leukemia 2011, 25:400-410.
15. Zangrando A., Intini F., te K.G., Basso G. Validation of NG2 antigen in identifying BP-ALL patients with MLL rearrangements using qualitative and quantitative flow cytometry: a prospective study. Leukemia 2008, 22:858-861.
16. De Z.L., Bicciato S., te K.G., Basso G. Computational analysis of flow-cytometry antigen expression profiles in childhood acute lymphoblastic leukemia: an MLL/AF4 identification. Leukemia 2003, 17:1557-1565.
17. Emerenciano M., Koifman S., Pombo-de-Oliveira M.S. Acute leukemia in early childhood. Braz J Med Biol Res 2007, 40:749-760.
18. Pombo de Oliveira M.S., Koifman S., Vasconcelos G.M., Emerenciano M., de Oliveira N.C. Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia. Blood Cells Mol Dis 2009, 42:121-125.
19. Bene M.C., Castoldi G., Knapp W., Ludwig W.D., Matutes E., Orfao A., et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 1995, 9:1783-1786.
20. Sing T., Sander O., Beerenwinkel N., Lengauer T. ROCR: visualizing classifier performance in R. Bioinformatics 2005, 21:3940-3941.
21. Boletim Regional do Banco Central do Brasil Evolução do IDH das Grandes Regiões e Unidades da Federação 2009, 7-1-2011. Internet source: http://www.bcb.gov.br/pec/boletimregional/port/2009/01/br200901b1p.pdf.
22. Human Development Reports Summary Human Development Report 2009 2009, 7-1-2011. Internet source: http://hdr.undp.org/en/media/HDR_2009_EN_HDI.pdf.
23. Gandemer V., Aubry M., Roussel M., Rio A.G., de T.M., Vallee A., et al. CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchart. Leuk Res 2010, 34:430-437.