Suppression of estrogen actions in human lung cancer

Molecular and Cellular Endocrinology

Volumn 340, Issue 2, 2011, Pages 168-174

  Miki, Yasuhiro ^a   Abe, Keiko ^a   Suzuki, Satoshi ^b   Suzuki, Takashi ^a   Sasano, Hironobu ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Ishinomaki Red Cross Hospital   (Japan)

Author keywords

Aromatase; Estrogen receptor; Lung carcinoma

Indexed keywords

ANASTROZOLE; AROMATASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; EXEMESTANE; FULVESTRANT; GEFITINIB; LETROZOLE;

ANTINEOPLASTIC ACTIVITY; CANCER HORMONE THERAPY; CANCER RISK; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ESTROGEN SYNTHESIS; HUMAN; LUNG NON SMALL CELL CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

AROMATASE; CARCINOMA, NON-SMALL-CELL LUNG; ESTROGENS; HUMANS; LUNG NEOPLASMS; RECEPTOR CROSS-TALK; RECEPTORS, ESTROGEN;

EID: 79960252746     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.02.018     Document Type: Review

References (51)

1. Abe K., Miki Y., Ono K., Mori M., Kakinuma H., Kou Y., Kudo K., Koguchi M., Niikawa H., Suzuki S., Evans D.B., Sugawara S., Suzuki T., Sasano H. Highly concordant coexpression of aromatase and estrogen receptor β in non-small cell lung cancer. Hum. Pathol. 2010, 41:190-198.
2. Cheng Y.S., Mues G., Wood D., Ding J. Aromatase expression in normal human oral keratinocytes and oral squamous cell carcinoma. Arch. Oral Biol. 2006, 51:612-620.
3. Chlebowski R.T., Schwartz A.G., Wakelee H., Anderson G.L., Stefanick M.L., Manson J.E., Rodabough R.J., Chien J.W., Wactawski-Wende J., Gass M., Kotchen J.M., Johnson K.C., O'Sullivan M.J., Ockene J.K., Chen C., Hubbell F.A. Women's Health Initiative Investigators Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet 2009, 374:1243-1251.
4. Conley A., Hinshelwood M. Mammalian aromatases. Reproduction 2001, 121:685-695.
5. Curtis S.W., Washburn T., Sewall C., DiAugustine R., Lindzey J., Couse J.F., Korach K.S. Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:12626-12630.
6. Dabbs D.J., Landreneau R.J., Liu Y., Raab S.S., Maley R.H., Tung M.Y., Silverman J.F. Detection of estrogen receptor by immunohistochemistry in pulmonary adenocarcinoma. Ann. Thorac. Surg. 2002, 73:403-405.
7. Dohi O., Hatori M., Suzuki T., Ono K., Hosaka M., Akahira J., Miki Y., Nagasaki S., Itoi E., Sasano H. Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. Cancer Sci. 2008, 99:518-523.
8. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science 1988, 240:889-895.
9. Fournet-Dulguerov N., MacLusky N.J., Leranth C.Z., Todd R., Mendelson C.R., Simpson E.R., Naftolin F. Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. J. Clin. Endocrinol. Metab. 1987, 65:757-764.
10. Ganti A.K., Sahmoun A.E., Panwalkar A.W., Tendulkar K.K., Potti A. Hormone replacement therapy is associated with decreased survival in women with lung cancer. J. Clin. Oncol. 2006, 24:59-63.
11. Gazdar A.F. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009, 28:S24-S31.
12. Gomez-Fernandez C., Mejias A., Walker G., Nadji M. Immunohistochemical expression of estrogen receptor in adenocarcinomas of the lung: the antibody factor. Appl. Immunohistochem. Mol. Morphol. 2010, 18:137-141.
13. Gustafsson J.A. Estrogen receptor beta - a new dimension in estrogen mechanism of action. J. Endocrinol. 1999, 163:379-383.
14. Hogan A.M., Collins D., Baird A.W., Winter D.C. Estrogen and gastrointestinal malignancy. Mol. Cell. Endocrinol. 2009, 307:19-24.
15. Howell A., Dowsett M. Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. Breast Cancer Res. 2004, 6:269-274.
16. Kawabata W., Suzuki T., Moriya T., Fujimori K., Naganuma H., Inoue S., Kinouchi Y., Kameyama K., Takami H., Shimosegawa T., Sasano H. Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions. Mod. Pathol. 2003, 16:437-444.
17. Kawai H., Ishii A., Washiya K., Konno T., Kon H., Yamaya C., Ono I., Minamiya Y., Ogawa J. Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer. Clin. Cancer Res. 2005, 11:5084-5089.
18. Koushik A., Parent M.E., Siemiatycki J. Characteristics of menstruation and pregnancy and the risk of lung cancer in women. Int. J. Cancer 2009, 125:2428-2433.
19. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Häggblad J., Nilsson S., Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997, 138:863-870.
20. Labrie F. Intracrinology. Mol. Cell. Endocrinol. 1991, 78:C113-C118.
21. Labrie F., Luu-The V., Labrie C., Bélanger A., Simard J., Lin S.X., Pelletier G. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr. Rev. 2003, 24:152-182.
22. Langner C., Ratschek M., Rehak P., Schips L., Zigeuner R. Steroid hormone receptor expression in renal cell carcinoma: an immunohistochemical analysis of 182 tumors. J. Urol. 2004, 171:611-614.
23. Liu Y., Inoue M., Sobue T., Tsugane S. Reproductive factors, hormone use and the risk of lung cancer among middle-aged never-smoking Japanese women: a large-scale population-based cohort study. Int. J. Cancer 2005, 117:662-666.
24. Mah V., Seligson D.B., Li A., Márquez D.C., Wistuba I.I., Elshimali Y., Fishbein M.C., Chia D., Pietras R.J., Goodglick L. Aromatase expression predicts survival in women with early-stage non-small cell lung cancer. Cancer Res. 2007, 67:10484-10490.
25. Márquez-Garbán D.C., Chen H.W., Goodglick L., Fishbein M.C., Pietras R.J. Targeting aromatase and estrogen signaling in human non-small cell lung cancer. Ann. N.Y. Acad. Sci. 2009, 1155:194-205.
26. Miki Y., Suzuki T., Sasano H. Controversies of aromatase localization in human breast cancer - stromal versus parenchymal cells. J. Steroid Biochem. Mol. Biol. 2007, 106:97-101.
27. Miki Y., Suzuki T., Tazawa C., Yamaguchi Y., Kitada K., Honma S., Moriya T., Hirakawa H., Evans D.B., Hayashi S., Ohuchi N., Sasano H. Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells. Cancer Res. 2007, 67:3945-3954.
28. Miki Y., Suzuki T., Abe K., Suzuki S., Niikawa H., Iida S., Hata S., Akahira J., Mori K., Evans D.B., Kondo T., Yamada-Okabe H., Sasano H. Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment. Cancer Res. 2010, 70:6659-6669.
29. Niikawa H., Suzuki T., Miki Y., Suzuki S., Nagasaki S., Akahira J.-I., Honma S., Evans D.B., Hayashi S.-I., Kondo T., Sasano H. Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma. Clin. Cancer Res. 2008, 14:4417-4426.
30. Nose N., Sugio K., Oyama T., Nozoe T., Uramoto H., Iwata T., Onitsuka T., Yasumoto K. Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. J. Clin. Oncol. 2009, 27:411-417.
31. Omoto Y., Kobayashi Y., Nishida K., Tsuchiya E., Eguchi H., Nakagawa K., Ishikawa Y., Yamori T., Iwase H., Fujii Y., Warner M., Gustafsson J.A., Hayashi S.I. Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers. Biochem. Biophys. Res. Commun. 2001, 285:340-347.
32. Oyama T., Kagawa N., Sugio K., Uramoto H., Hatano O., Harada N., Kaneko K., Kawamoto T., Yasumoto K. Expression of aromatase CYP19 and its relationship with parameters in NSCLC. Front. Biosci. 2009, 14:2285-2292.
33. Payne S. Gender in lung cancer and smoking research. Gender and health research series. WHO Library Cataloguing-in-Publication Data 2005, WHO Press, Geneva.
34. Pietras R.J., Márquez D.C., Chen H.W., Tsai E., Weinberg O., Fishbein M. Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells. Steroids 2005, 70:372-381.
35. Prkin M., Tyczynski J.E., Boffeta P., Samet J., Shields P., Caporaso N. Lung cancer epidemiology and etiology. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart 2004, 12-15. IARC Press, Lyon. W.D. Travis, E. Brambilla, H.K. Muller-Hermelink, C.C. Harriss (Eds.).
36. Radzikowska E., Langfort R., Giedronowicz D. Estrogen and progesterone receptors in non small cell lung cancer patients. Ann. Thorac. Cardiovasc. Surg. 2002, 8:69-73.
37. Raz D.J., He B., Rosell R., Jablons D.M. Bronchioloalveolar carcinoma: a review. Clin. Lung Cancer 2006, 7:313-322.
38. Sasano H., Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr. Rev. 1998, 19:593-607.
39. Sasano H., Anderson T.J., Silverberg S.G., Santen R.J., Conway M., Edwards D.P., Krause A., Bhatnagar A.S., Evans D.B., Miller W.R. The validation of new aromatase monoclonal antibodies for immunohistochemistry - a correlation with biochemical activities in 46 cases of breast cancer. J. Steroid Biochem. Mol. Biol. 2005, 95:35-39.
40. Sasano H., Miki Y., Nagasaki S., Suzuki T. In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to intracrinology. Pathol. Int. 2009, 59:777-789.
41. Sato R., Suzuki T., Katayose Y., Miura K., Shiiba K., Tateno H., Miki Y., Akahira J., Kamogawa Y., Nagasaki S., Yamamoto K., Ii T., Egawa S., Evans D.B., Unno M., Sasano H. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res. 2009, 69:914-922.
42. Schwartz A.G., Prysak G.M., Murphy V., Lonardo F., Pass H., Schwartz J., Brooks S. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin. Cancer Res. 2005, 11:7280-7287.
43. Sica G., Wagner P.L., Altorki N., Port J., Lee P.C., Vazquez M.F., Saqi A. Immunohistochemical expression of estrogen and progesterone receptors in primary pulmonary neuroendocrine tumors. Arch. Pathol. Lab. Med. 2008, 132:1889-1895.
44. Skov B.G., Fischer B.M., Pappot H. Oestrogen receptor beta over expression in males with non-small cell lung cancer is associated with better survival. Lung Cancer 2008, 59:88-94.
45. Slatore C.G., Chien J.W., Au D.H., Satia J.A., White E. Lung cancer and hormone replacement therapy: association in the vitamins and lifestyle study. J. Clin. Oncol. 2010, 28:1540-1546.
46. Stabile L.P., Davis A.L., Gubish C.T., Hopkins T.M., Luketich J.D., Christie N., Finkelstein S., Siegfried J.M. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res. 2002, 62:2141-2150.
47. Stabile L.P., Lyker J.S., Gubish C.T., Zhang W., Grandis J.R., Siegfried J.M. Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects. Cancer Res. 2005, 65:1459-1470.
48. Suzuki T., Miki Y., Nakamura Y., Moriya T., Ito K., Ohuchi N., Sasano H. Sex steroid-producing enzymes in human breast cancer. Endocr. Relat. Cancer 2005, 12:701-720.
49. Taylor A.H., Al-Azzawi F. Immunolocalisation of oestrogen receptor beta in human tissues. J. Mol. Endocrinol. 2000, 24:145-155.
50. Traynor A.M., Schiller J.H., Stabile L.P., Kolesar J.M., Eickhoff J.C., Dacic S., Hoang T., Dubey S., Marcotte S.M., Siegfried J.M. Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer. Lung Cancer 2009, 64:51-59.
51. Weinberg O.K., Marquez-Garban D.C., Fishbein M.C., Goodglick L., Garban H.J., Dubinett S.M., Pietras R.J. Aromatase inhibitors in human lung cancer therapy. Cancer Res. 2005, 65:11287-11291.