Process optimization for continuous extrusion wet granulation

Pharmaceutical Development and Technology

Volumn 16, Issue 4, 2011, Pages 302-315

  Tan, Li ^b   Carella, Anthony J ^a   Ren, Yukun ^a   Lo, Julian B ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Binder; Continuous processing; Extrusion; High loading; High shear; Wet granulation

Indexed keywords

HYDROXYPROPYLCELLULOSE; PARACETAMOL; POLYMETHACRYLIC ACID; POVIDONE;

ARTICLE; DENSITY; DRUG DISTRIBUTION; DRUG GRANULATION; DRUG RELEASE; EXTRUSION GRANULATION; HIGH SHEAR GRANULATION; INTERMETHOD COMPARISON; PRIORITY JOURNAL; STOMACH JUICE; TABLET; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET MANUFACTURE; TENSILE STRENGTH;

ACETAMINOPHEN; ANALYSIS OF VARIANCE; CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; POVIDONE; POWDERS; SHEAR STRENGTH; SOLUBILITY; TABLETS; TENSILE STRENGTH;

EID: 79960227620     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837451003692587     Document Type: Article

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