Use of prediction methods to estimate true density of active pharmaceutical ingredients

International Journal of Pharmaceutics

Volumn 355, Issue 1-2, 2008, Pages 231-237

  Cao, Xiaoping ^a   Leyva, Norma ^a   Anderson, Stephen R ^a   Hancock, Bruno C ^a  

^a PFIZER INC   (United States)

Author keywords

Active pharmaceutical ingredient; Density; Helium pycnometry; Mathematical model; Prediction

Indexed keywords

BENZOCAINE; IBUPROFEN; INDOMETACIN; KETOPROFEN; LIDOCAINE; NICOTINAMIDE; PARACETAMOL; PHENACETIN;

ANALYTICAL ERROR; ARTICLE; DENSITY; DRUG INDUSTRY; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; MOLECULAR WEIGHT; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DATA INTERPRETATION, STATISTICAL; FORECASTING; HELIUM; MODELS, STATISTICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHENACETIN;

EID: 41349101294     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.12.012     Document Type: Article

References (24)

1. Cady H.H. Estimation of the Density of Organic Explosives From Their Structural Formulas (1979), Los Alamos Sci. Lab., Los Alamos, NM, USA p. 24
2. Exner O. Additive physical properties. II. Molar volume as an additive property. Collect. Czech. Chem. Commun. 32 (1967) 1-23
3. Fedors R.F. Method for estimating both the solubility parameters and molar volumes of liquids. Polym. Eng. Sci. 14 (1974) 147-154
4. Geng P., and Kuznetsov A.V. Settling of bidispersed small solid particles in a dilute suspension containing gyrotactic micro-organisms. Int. J. Eng. Sci. 43 (2005) 992-1010
5. Girolami G.S. A simple "back of the envelope" method for estimating the densities and molecular volumes of liquids and solids. J. Chem. Educ. 71 (1994) 962-964
6. Hancock B.C., and Rowe R.C. The thermal expansion of pharmaceutical solids. S.T.P. Pharma Sci. 8 (1998) 213-220
7. Hancock B.C., Colvin J.T., Mullarney M.P., and Zinchuk A.V. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharm. Technol. 27 (2003) 64-80
8. Heckel R.W. Density-pressure relations in powder compaction. Trans. Metallogr. Soc. AIME 221 (1961) 671-675
9. Hedden D.B., Brone D.L., Clement S., McCall M., Olsofsky A., Patel P.J., Prescott J., and Hancock B.C. Development of an improved fluidization segregation tester for use with pharmaceutical powders. Pharm. Technol. 30 (2006) 56-64
10. Immirzi A., and Perini B. Prediction of density in organic crystals. Acta Crystallogr. A 33 (1977) 216-218
11. Kitaigorodski A.I. Molecular Crystals and Molecules (1973), Academic Press, New York
12. Leung S.S., Padden B.E., Munson E.J., and Grant D.J.W. Solid-state characterization of two polymorphs of aspartame hemihydrate. J. Pharm. Sci. 87 (1998) 501-507
13. Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23 (1997) 3-25
14. Lyman W.J., Reehl W.F., and Rosenblatt D.H. Handbook of Chemical Property Estimation Methods: Environmental Behavior of Organic Compounds (1990), American Chemical Society, Washington, DC pp. 19-14-19-23
15. Pauling L. The Nature of the Chemical Bond (1960), Cornell University, Ithaca, NY p. 260
16. Piacenza G., Jacob G., and Gallo R. The prediction of density. Adv. Quant. Struct.-Property Relationships 3 (2002) 67-107
17. Richards F.M., and Lindley P.F. Determination of the density of solids. In: Prince E. (Ed). International Tables for Crystallography (2006), Springer, Dordrecht, Netherlands 156-159
18. Stine J.R. Prediction of Crystal Densities of Organic Explosives by Group Additivity (1981), Los Alamos Natl. Lab., Los Alamos, NM, USA p. 28
19. Sun C. A novel method for deriving true density of pharmaceutical solids including hydrates and water-containing powders. J. Pharm. Sci. 93 (2004) 646-653
20. Sun C. True density of microcrystalline cellulose. J. Pharm. Sci. 94 (2005) 2132-2134
21. Sun C.C. Quantifying errors in tableting data analysis using the ryshkewitch equation due to inaccurate true density. J. Pharm. Sci. 94 (2005) 2061-2068
22. Sun C.C. Thermal expansion of organic crystals and precision of calculated crystal density: a survey of cambridge crystal database. J. Pharm. Sci. 96 (2007) 1043-1052
23. Sun C., and Grant D.J.W. Influence of crystal structure on the tableting properties of sulfamerazine polymorphs. Pharm. Res. 18 (2001) 274-280
24. Viana M., Jouannin P., Pontier C., and Chulia D. About pycnometric density measurements. Talanta 57 (2002) 583-593