Relationship of amyloid-beta burden with age-at-onset in alzheimer disease

American Journal of Geriatric Psychiatry

Volumn 19, Issue 7, 2011, Pages 627-634

  Choo, Il Han ^a   Lee, Dong Young ^a,c   Kim, Jee Wook ^a   Seo, Eun Hyun ^a,c   Lee, Dong Soo ^b   Kim, Yu Kyeong ^d   Kim, Shin Gyeom ^e   Park, Shin Young ^f   Woo, Jong Inn ^a,c   Yoon, Eun Jin ^d  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

^e Soonchunhyang University   (South Korea)

^f The Catholic University of Korea   (South Korea)

Author keywords

11C PIB; Alzheimer disease; amyloid beta; early onset; late onset

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; PITTSBURGH COMPOUND B;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; DISEASE DURATION; DISEASE SEVERITY; FRONTAL CORTEX; HUMAN; OCCIPITAL CORTEX; ONSET AGE; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; TEMPORAL CORTEX;

EID: 79960210779     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e318202bf3a     Document Type: Article

References (36)

1. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944 (Pubitemid 14076461)
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4 ed. Washington, DC: American Psychiatric Association, 1994
3. Chui HC, Teng EL, Henderson VW, et al: Clinical subtypes of dementia of the Alzheimer type. Neurology 1985; 35: 1544-1550 (Pubitemid 16248660)
4. Seltzer B, Sherwin I: A comparison of clinical features in earlyand late-onset primary degenerative dementia. One entity or two? Arch Neurol 1983; 40:143-146 (Pubitemid 13139113)
5. Binetti G, Magni E, Padovani A, et al: Neuropsychological heterogeneity in mild Alzheimer's disease. Dementia 1993; 4: 321-326 (Pubitemid 23355772)
6. Kim EJ, Cho SS, Jeong Y, et al: Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients. Brain 2005; 128:1790-1801 (Pubitemid 41373650)
7. Kemp PM, Holmes C, Hoffmann SM, et al: Alzheimer's disease: differences in technetium-99m HMPAO SPECT scan findings between early onset and late onset dementia. J Neurol Neurosurg Psychiatry 2003; 74:715-719 (Pubitemid 36628280)
8. Frisoni GB, Testa C, Sabattoli F, et al: Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study. J Neurol Neurosurg Psychiatry 2005; 76:112-114 (Pubitemid 40013502)
9. Frisoni GB, Pievani M, Testa C, et al: The topography of grey matter involvement in early and late onset Alzheimer's disease. Brain 2007; 130:720-730 (Pubitemid 46410740)
10. Marshall GA, Fairbanks LA, Tekin S, et al: Early-onset Alzheimer's disease is associated with greater pathologic burden. J Geriatr Psychiatry Neurol 2007; 20:29-33 (Pubitemid 46233616)
11. Ho GJ, Hansen LA, Alford MF, et al: Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease. Neuroreport 2002; 13:1825-1828 (Pubitemid 35333171)
12. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297:353-356 (Pubitemid 34790756)
13. Klunk WE, Engler H, Nordberg A, et al: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004; 55:306-319 (Pubitemid 38269583)
14. Rowe CC, Ng S, Ackermann U, et al: Imaging beta-amyloid burden in aging and dementia. Neurology 2007; 68:1718-1725 (Pubitemid 46763260)
15. Drzezga A, Grimmer T, Henriksen G, et al: Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology 2009; 72:1487-1494
16. Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993; 43:2412-2414 (Pubitemid 23346995)
17. Lee JH, Lee KU, Lee DY, et al: Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. J Gerontol B Psychol Sci Soc Sci 2002; 57:P47-P53 (Pubitemid 34052886)
18. Lee DY, Lee KU, Lee JH, et al: A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J Int Neuropsychol Soc 2004; 10:72-81 (Pubitemid 38128464)
19. Seo EH, Lee DY, Choo IH, et al: Normative study of the Stroop Color and Word Test in an educationally diverse elderly population. Int J Geriatr Psychiatry 2008; 23:1020-1027
20. Fazekas F, Chawluk JB, Alavi A, et al: MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987; 149:351-356 (Pubitemid 17104996)
21. Lopresti BJ, Klunk WE, Mathis CA, et al: Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: A comparative analysis. J Nucl Med 2005; 46:1959-1972 (Pubitemid 46657441)
22. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002; 15:273-289 (Pubitemid 34852226)
23. Reiman EM, Chen K, Liu X, et al: Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proc Natl Acad Sci USA 2009; 106:6820-6825
24. Edison P, Rowe CC, Rinne JO, et al: Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry 2008; 79:1331-1338
25. Edison P, Archer HA, Hinz R, et al: Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 2007; 68:501-508
26. Katzman R: Education and the prevalence of dementia and Alzheimer's disease. Neurology 1993; 43:13-20 (Pubitemid 23035350)
27. DeCarli C, Massaro J, Harvey D, et al: Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol Aging 2005; 26: 491-510 (Pubitemid 40093933)
28. Pfefferbaum A, Mathalon DH, Sullivan EV, et al: A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 1994; 51:874-887 (Pubitemid 24286042)
29. Stern Y: What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002; 8:448-460 (Pubitemid 34296102)
30. Damoiseaux JS, Beckmann CF, Arigita EJ, et al: Reduced restingstate brain activity in the "default network" in normal aging. Cereb Cortex 2008; 18:1856-1864 (Pubitemid 352019901)
31. O'Sullivan M, Jones DK, Summers PE, et al: Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology 2001; 57:632-638 (Pubitemid 32782990)
32. Geula C, Wu CK, Saroff D, et al: Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 1998; 4: 827-831 (Pubitemid 28331025)
33. Brouwers N, Sleegers K, van Broeckhoven C: Molecular genetics of Alzheimer's disease: an update. Ann Med 2008; 40: 562-583
34. Mitrushina MN, Boone KB, D'Elia L: Handbook of Normative Data for Neuropsychological Assessment. New York: Oxford University Press, 1999
35. Roses AD: Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med 1996; 47:387-400 (Pubitemid 26138899)
36. Corder EH, Saunders AM, Strittmatter WJ, et al: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261:921-923 (Pubitemid 23275809)