Pharmacokinetics of Oral Cyanocobalamin Formulated With Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): An Open-Label, Randomized, Single-Dose, Parallel-Group Study in Healthy Male Subjects

Clinical Therapeutics

Volumn 33, Issue 7, 2011, Pages 934-945

  Castelli, M Cristina ^a   Wong, Diane F ^a   Friedman, Kristen ^a   Riley, M Gary I ^a  

^a Emisphere Technologies   (United States)

Author keywords

B12; Cobalamin; Cyanocobalamin; Oral; Pharmacokinetics; SNAC

Indexed keywords

CYANOCOBALAMIN; OCTANOIC ACID DERIVATIVE; SODIUM N [8 (2 HYDROXYBENZOYL)AMINO]CAPRYLATE; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ANAMNESIS; AREA UNDER THE CURVE; ARTICLE; BLOOD CHEMISTRY; BODY MASS; BODY WEIGHT; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG MARKETING; DRUG MONITORING; DRUG RELEASE; DRUG TOLERABILITY; DRUG UPTAKE; ELECTROCARDIOGRAPHY; HUMAN; HUMAN EXPERIMENT; LABORATORY TEST; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHYSICAL EXAMINATION; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; VALIDATION PROCESS; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CAPRYLATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FEASIBILITY STUDIES; HUMANS; MALE; MIDDLE AGED; TABLETS; TIME FACTORS; VITAMIN B 12; VITAMIN B COMPLEX; YOUNG ADULT;

EID: 79960207683     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2011.05.088     Document Type: Article

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