Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse

Neurobiology of Disease

Volumn 43, Issue 3, 2011, Pages 635-641

  Dallérac, Glenn ^a,b   Perronnet, Caroline ^a,b   Chagneau, Carine ^a,b   Leblanc Veyrac, Pascale ^a,b   Samson Desvignes, Nathalie ^a,b   Peltekian, Elise ^d,e   Danos, Olivier ^f,g,h   Garcia, Luis ^d,e   Laroche, Serge ^a,b   Billard, Jean Marie ^c   Vaillend, Cyrille ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

^c CENTRE DE PSYCHIATRIE ET NEUROSCIENCES   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f HÔPITAL NECKER ENFANTS MALADES   (France)

^g INSERM   (France)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

AAV vector; Adult brain; Dystrophin; Exon skipping; GABA receptor; Gene therapy; Hippocampus; Inhibition; Mdx mouse; Synaptic plasticity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DYSTROPHIN; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DUCHENNE MUSCULAR DYSTROPHY; EXON SKIPPING; FEMALE; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM;

AGE FACTORS; ANIMALS; DEPENDOVIRUS; DYSTROPHIN; EVOKED POTENTIALS; EXONS; FEMALE; GENE THERAPY; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCULAR DYSTROPHY, DUCHENNE; NEURAL INHIBITION; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; RECEPTORS, GABA-A; SYNAPSES;

EID: 79960205352     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.05.012     Document Type: Article

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