Formulation, pharmacokinetics and biodistribution of Ofloxacin-loaded albumin microparticles and nanoparticles

Journal of Microencapsulation

Volumn 28, Issue 5, 2011, Pages 363-369

  Lee, K N ^a,b   Ye, Y ^a   Carr, J H ^a   Karem, K ^a   D'Souza, M J ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b MERCER UNIVERSITY   (United States)

Author keywords

Fluoroquinolone; HPMCAS; Hypromellose acetate succinate; Microparticles; Nanoparticles; Spray dryer

Indexed keywords

ALBUMIN; HYPOMELLOSE ACETATE SUCCINATE; NANOPARTICLE; OFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; INFUSION PUMP; LIVER; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; SINGLE DRUG DOSE; SPLEEN; SUSTAINED DRUG RELEASE; ZETA POTENTIAL;

ALBUMINS; ANIMALS; ANTI-BACTERIAL AGENTS; DRUG CARRIERS; MICE; MICE, INBRED BALB C; NANOPARTICLES; OFLOXACIN; PARTICLE SIZE; PHARMACOKINETICS; TISSUE DISTRIBUTION;

EID: 79960203364     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2011.569766     Document Type: Article

References (13)

1. Addo RT, Siddig A, Siwale R, Patel NJ, Akande J, Uddin AN, DSouza MJ. Formulation, characterization and testing of tetracaine hydrochloride-loaded albumin-chitosan microparticles for ocular drug delivery. J Microencapsul, 2010;27(2):95-104.
2. Akande J, Yeboah KG, Addo RT, Siddig A, Oettinger CW, DSouza MJ. Targeted delivery of antigens to the gut-associated lymphoid tissues: 2. Ex vivo evaluation of lectin-labelled albumin microspheres for targeted delivery of antigens to the M-cells of the Peyers patches. J Microencapsul, 2010;27(4):325-36.
3. Arbos P, Campanero MA, Arangoa MA, Irache JM. Nanoparticles with specific bioadhesive properties to circumvent pre -systemic degradation of fluorinated pyrimidines. J Controlled Release, 2004;96:55-65. (Pubitemid 38438489)
4. Barratt G. Colloidal drug carriers: Achievements and perspectives. Cell Mol Life Sci, 2003;60:21-37. (Pubitemid 36223115)
5. Fresta M, Puglisi G, Giammona G, Cavallaro G, Micali N, Furneri PM. Pefloxacin mesilate- and ofloxacin loaded polyethylcyanoacrylate nanoparticles: Characterization of the colloidal drug carrier formulation. J Pharm Sci, 1995;84(7):895-902.
6. Hooper DC, Rubinstein E., 2003. Quinolone antimicrobial agents. Washington, DC: ASM Press.
7. Kastner M, Rahm U, Baumann-Wilschke I, Bello A, Stahlmann R. Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats. Arch Toxicol, 2004;78:61-7. (Pubitemid 38316660)
8. Kohane DS. Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng, 2007;96(2):203-9. (Pubitemid 46232255)
9. Kratz F. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. J Controlled Release, 2008;132:171-83.
10. Stahlmann R, Förster C, Shakibaei M, Vormann J, Günther T, Merker HJ. Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. Antimicrob Agents Chemother, 1995;39(9):2013-18.
11. Tajber L, Corrigan OI, Healy AM. Spray drying of budensonide, formoterol fumarate and their composites-II statistical factorial design and in vitro deposition properties. Int J Pharm, 2009; 367:89-96.
12. Tanno FK, Sakuma S, Masaoka Y, Kataoka M, Kozaki T, Kamaguchi R, Ikeda Y, Kokubo H, Yamashita S. Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS). J Pharm Sci, 2008; 97(7):2665-79.
13. Tom RT, Suryanarayanan V, Ganapati Reddy P, Baskaran S, Pradeep T. Ciprofloxacin-protected gold nanoparticles. Am Chem Soc, 2004;20:1909-14.