메뉴 건너뛰기




Volumn 10, Issue 12, 2011, Pages 762-765

Immunopathogenesis of vitiligo

Author keywords

Autoimmunity; Melanocyte; Pathogenesis; Vitiligo

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CYTOKINE; ENDOTHELIN 1; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960180411     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.02.004     Document Type: Review
Times cited : (127)

References (42)
  • 1
    • 77953519387 scopus 로고    scopus 로고
    • Vitiligo: pathogenetic hypotheses and targets for current therapies
    • Guerra L., Dellambra E., Brescia S., Raskovic D. Vitiligo: pathogenetic hypotheses and targets for current therapies. Curr Drug Metab Jun 1 2010, 11(5):451-467.
    • (2010) Curr Drug Metab , vol.11 , Issue.5 , pp. 451-467
    • Guerra, L.1    Dellambra, E.2    Brescia, S.3    Raskovic, D.4
  • 2
    • 73349120629 scopus 로고    scopus 로고
    • Vitiligo in children
    • Kakourou T. Vitiligo in children. World J Pediatr Nov 2009, 5(4):265-268.
    • (2009) World J Pediatr , vol.5 , Issue.4 , pp. 265-268
    • Kakourou, T.1
  • 6
    • 0037648525 scopus 로고    scopus 로고
    • Evidence for an autoimmune pathogenesis of vitiligo
    • Ongenae K., Van Geel N., Naeyaert J.M. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res Apr 2003, 16(2):90-100.
    • (2003) Pigment Cell Res , vol.16 , Issue.2 , pp. 90-100
    • Ongenae, K.1    Van Geel, N.2    Naeyaert, J.M.3
  • 7
    • 28444489322 scopus 로고    scopus 로고
    • Physiopathology and genetics of vitiligo
    • Passeron T., Ortonne J.P. Physiopathology and genetics of vitiligo. J Autoimmun 2005, 25(Suppl):63-68.
    • (2005) J Autoimmun , vol.25 , Issue.SUPPL , pp. 63-68
    • Passeron, T.1    Ortonne, J.P.2
  • 8
    • 70450265240 scopus 로고    scopus 로고
    • The double strike hypothesis of the vitiligo pathomechanism: new approaches to vitiligo and melanoma
    • Michelsen D. The double strike hypothesis of the vitiligo pathomechanism: new approaches to vitiligo and melanoma. Med Hypotheses Jan 2010, 74(1):67-70.
    • (2010) Med Hypotheses , vol.74 , Issue.1 , pp. 67-70
    • Michelsen, D.1
  • 10
    • 33846569338 scopus 로고    scopus 로고
    • Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo
    • Kemp E.H., Gavalas N.G., Gawkrodger D.J., Weetman A.P. Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo. Autoimmun Rev Jan 2007, 6(3):138-142.
    • (2007) Autoimmun Rev , vol.6 , Issue.3 , pp. 138-142
    • Kemp, E.H.1    Gavalas, N.G.2    Gawkrodger, D.J.3    Weetman, A.P.4
  • 12
    • 0034523075 scopus 로고    scopus 로고
    • IgG anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes
    • Li Y.L., Yu C.L., Yu H.S. IgG anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes. J Invest Dermatol Dec 2000, 115(6):969-973.
    • (2000) J Invest Dermatol , vol.115 , Issue.6 , pp. 969-973
    • Li, Y.L.1    Yu, C.L.2    Yu, H.S.3
  • 14
    • 72049108353 scopus 로고    scopus 로고
    • Autoantigens in vitiligo identified by the serological selection of a phage-displayed melanocyte cDNA expression library
    • Waterman E.A., Gawkrodger D.J., Watson P.F., Weetman A.P., Kemp E.H. Autoantigens in vitiligo identified by the serological selection of a phage-displayed melanocyte cDNA expression library. J Invest Dermatol Jan 2010, 130(1):230-240.
    • (2010) J Invest Dermatol , vol.130 , Issue.1 , pp. 230-240
    • Waterman, E.A.1    Gawkrodger, D.J.2    Watson, P.F.3    Weetman, A.P.4    Kemp, E.H.5
  • 17
    • 0032555910 scopus 로고    scopus 로고
    • High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo
    • Ogg G.S., Rod Dunbar P., Romero P., Chen J.L., Cerundolo V. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo. J Exp Med Sep 21 1998, 188(6):1203-1208.
    • (1998) J Exp Med , vol.188 , Issue.6 , pp. 1203-1208
    • Ogg, G.S.1    Rod Dunbar, P.2    Romero, P.3    Chen, J.L.4    Cerundolo, V.5
  • 18
    • 0035721929 scopus 로고    scopus 로고
    • Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo
    • Palermo B., Campanelli R., Garbelli S., Mantovani S., Lantelme E., Brazzelli V., Ardigó M., Borroni G., Martinetti M., Badulli C., Necker A., Giachino C. Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo. J Invest Dermatol Aug 2001, 117(2):326-332.
    • (2001) J Invest Dermatol , vol.117 , Issue.2 , pp. 326-332
    • Palermo, B.1    Campanelli, R.2    Garbelli, S.3    Mantovani, S.4    Lantelme, E.5    Brazzelli, V.6    Ardigó, M.7    Borroni, G.8    Martinetti, M.9    Badulli, C.10    Necker, A.11    Giachino, C.12
  • 20
    • 12344268632 scopus 로고    scopus 로고
    • Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: implications for the pathophysiology of vitiligo
    • Steitz J., Wenzel J., Gaffal E., Tüting T. Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: implications for the pathophysiology of vitiligo. Eur J Cell Biol Dec 2004, 83(11-12):797-803.
    • (2004) Eur J Cell Biol , vol.83 , Issue.11-12 , pp. 797-803
    • Steitz, J.1    Wenzel, J.2    Gaffal, E.3    Tüting, T.4
  • 21
    • 0033889236 scopus 로고    scopus 로고
    • Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+T cells at the perilesional site
    • van den Wijngaard R., Wankowicz-Kalinska A., Le Poole C., Tigges B., Westerhof W., Das P. Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+T cells at the perilesional site. Lab Invest Aug 2000, 80(8):1299-1309.
    • (2000) Lab Invest , vol.80 , Issue.8 , pp. 1299-1309
    • van den Wijngaard, R.1    Wankowicz-Kalinska, A.2    Le Poole, C.3    Tigges, B.4    Westerhof, W.5    Das, P.6
  • 24
    • 11944251002 scopus 로고    scopus 로고
    • Peripheral CD8+ T cell tolerance against melanocytic self-antigens in the skin is regulated in two steps by CD4+ T cells and local inflammation: implications for the pathophysiology of vitiligo
    • Steitz J., Brück J., Lenz J., Büchs S., Tüting T. Peripheral CD8+ T cell tolerance against melanocytic self-antigens in the skin is regulated in two steps by CD4+ T cells and local inflammation: implications for the pathophysiology of vitiligo. J Invest Dermatol Jan 2005, 124(1):144-150.
    • (2005) J Invest Dermatol , vol.124 , Issue.1 , pp. 144-150
    • Steitz, J.1    Brück, J.2    Lenz, J.3    Büchs, S.4    Tüting, T.5
  • 26
    • 0036587415 scopus 로고    scopus 로고
    • Idiopathic CD4+T-cell lymphocytopenia associated with vitiligo
    • Yamauchi P.S., Nguyen N.Q., Grimes P.E. Idiopathic CD4+T-cell lymphocytopenia associated with vitiligo. J Am Acad Dermatol May 2002, 46(5):779-782.
    • (2002) J Am Acad Dermatol , vol.46 , Issue.5 , pp. 779-782
    • Yamauchi, P.S.1    Nguyen, N.Q.2    Grimes, P.E.3
  • 27
    • 0242635680 scopus 로고    scopus 로고
    • Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin
    • Le Poole I.C., Stennett L.S., Bonish B.K., Dee L., Robinson J.K., Hernandez C., Hann S.K., Nickoloff B.J. Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin. Br J Dermatol Oct 2003, 149(4):739-748.
    • (2003) Br J Dermatol , vol.149 , Issue.4 , pp. 739-748
    • Le Poole, I.C.1    Stennett, L.S.2    Bonish, B.K.3    Dee, L.4    Robinson, J.K.5    Hernandez, C.6    Hann, S.K.7    Nickoloff, B.J.8
  • 28
    • 77953346767 scopus 로고    scopus 로고
    • Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population
    • Zamani M., Tabatabaiefar M.A., Mosayyebi S., Mashaghi A., Mansouri P. Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population. Clin Exp Dermatol Jul 2010, 35(5):521-524.
    • (2010) Clin Exp Dermatol , vol.35 , Issue.5 , pp. 521-524
    • Zamani, M.1    Tabatabaiefar, M.A.2    Mosayyebi, S.3    Mashaghi, A.4    Mansouri, P.5
  • 30
    • 68849101888 scopus 로고    scopus 로고
    • Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio
    • Pichler R., Sfetsos K., Badics B., Gutenbrunner S., Berg J., Auböck J. Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio. Wien Med Wochenschr 2009, 159(13-14):337-341.
    • (2009) Wien Med Wochenschr , vol.159 , Issue.13-14 , pp. 337-341
    • Pichler, R.1    Sfetsos, K.2    Badics, B.3    Gutenbrunner, S.4    Berg, J.5    Auböck, J.6
  • 31
    • 52249115853 scopus 로고    scopus 로고
    • Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometric study
    • Basak P.Y., Adiloglu A.K., Koc I.G., Tas T., Akkaya V.B. Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometric study. J Eur Acad Dermatol Venereol Aug 2008, 22(8):970-976.
    • (2008) J Eur Acad Dermatol Venereol , vol.22 , Issue.8 , pp. 970-976
    • Basak, P.Y.1    Adiloglu, A.K.2    Koc, I.G.3    Tas, T.4    Akkaya, V.B.5
  • 33
    • 0036189447 scopus 로고    scopus 로고
    • Decreased total numbers of peripheral blood lymphocytes with elevated percentages of CD4+CD45RO+and CD4+CD25+ of T-helper cells in non-segmental vitiligo
    • Mahmoud F., Abul H., Haines D., Al-Saleh C., Khajeji M., Whaley K. Decreased total numbers of peripheral blood lymphocytes with elevated percentages of CD4+CD45RO+and CD4+CD25+ of T-helper cells in non-segmental vitiligo. J Dermatol Feb 2002, 29(2):68-73.
    • (2002) J Dermatol , vol.29 , Issue.2 , pp. 68-73
    • Mahmoud, F.1    Abul, H.2    Haines, D.3    Al-Saleh, C.4    Khajeji, M.5    Whaley, K.6
  • 34
    • 0029932239 scopus 로고    scopus 로고
    • Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance
    • Le Poole I.C., van den Wijngaard R.M., Westerhof W., Das P.K. Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance. Am J Pathol Apr 1996, 148(4):1219-1228.
    • (1996) Am J Pathol , vol.148 , Issue.4 , pp. 1219-1228
    • Le Poole, I.C.1    van den Wijngaard, R.M.2    Westerhof, W.3    Das, P.K.4
  • 35
    • 65249187176 scopus 로고    scopus 로고
    • Mapping of melanin-concentrating hormone receptor 1 B cell epitopes predicts two major binding sites for vitiligo patient autoantibodies
    • Gavalas N.G., Gottumukkala R.V., Gawkrodger D.J., Watson P.F., Weetman A.P., Kemp E.H. Mapping of melanin-concentrating hormone receptor 1 B cell epitopes predicts two major binding sites for vitiligo patient autoantibodies. Exp Dermatol May 2009, 18(5):454-463.
    • (2009) Exp Dermatol , vol.18 , Issue.5 , pp. 454-463
    • Gavalas, N.G.1    Gottumukkala, R.V.2    Gawkrodger, D.J.3    Watson, P.F.4    Weetman, A.P.5    Kemp, E.H.6
  • 36
    • 0344267746 scopus 로고    scopus 로고
    • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients
    • Yeo U.C., Yang Y.S., Park K.B., Sung H.T., Jung S.Y., Lee E.S., Shin M.H. Serum concentration of the soluble interleukin-2 receptor in vitiligo patients. J Dermatol Sci Apr 1999, 19(3):182-188.
    • (1999) J Dermatol Sci , vol.19 , Issue.3 , pp. 182-188
    • Yeo, U.C.1    Yang, Y.S.2    Park, K.B.3    Sung, H.T.4    Jung, S.Y.5    Lee, E.S.6    Shin, M.H.7
  • 37
    • 85052661690 scopus 로고    scopus 로고
    • Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo
    • Yu H.S., Chang K.L., Yu C.L., Li H.F., Wu M.T., Wu C.S., Wu C.S. Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo. J Invest Dermatol Apr 1997, 108(4):527-529.
    • (1997) J Invest Dermatol , vol.108 , Issue.4 , pp. 527-529
    • Yu, H.S.1    Chang, K.L.2    Yu, C.L.3    Li, H.F.4    Wu, M.T.5    Wu, C.S.6    Wu, C.S.7
  • 38
    • 58149345045 scopus 로고    scopus 로고
    • The role of helper and regulatory T cells in the pathogenesis of vitiligo
    • Basak P.Y., Adiloglu A.K., Ceyhan A.M., Tas T., Akkaya V.B. The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol Feb 2009, 60(2):256-260.
    • (2009) J Am Acad Dermatol , vol.60 , Issue.2 , pp. 256-260
    • Basak, P.Y.1    Adiloglu, A.K.2    Ceyhan, A.M.3    Tas, T.4    Akkaya, V.B.5
  • 39
  • 40
    • 68849103736 scopus 로고    scopus 로고
    • Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis
    • Moretti S., Fabbri P., Baroni G., Berti S., Bani D., Berti E., Nassini R., Lotti T., Massi D. Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis. Histol Histopathol Jul 2009, 24(7):849-857.
    • (2009) Histol Histopathol , vol.24 , Issue.7 , pp. 849-857
    • Moretti, S.1    Fabbri, P.2    Baroni, G.3    Berti, S.4    Bani, D.5    Berti, E.6    Nassini, R.7    Lotti, T.8    Massi, D.9
  • 41
    • 58149174208 scopus 로고    scopus 로고
    • Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients
    • Namian A.M., Shahbaz S., Salmanpoor R., Namazi M.R., Dehghani F., Kamali-Sarvestani E. Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients. Arch Dermatol Res Jan 2009, 301(1):21-25.
    • (2009) Arch Dermatol Res , vol.301 , Issue.1 , pp. 21-25
    • Namian, A.M.1    Shahbaz, S.2    Salmanpoor, R.3    Namazi, M.R.4    Dehghani, F.5    Kamali-Sarvestani, E.6
  • 42
    • 77957096818 scopus 로고    scopus 로고
    • Abnormal DNA methylation in peripheral blood mononuclear cells from patients with vitiligo
    • Zhao M., Gao F., Wu X., Tang J., Lu Q. Abnormal DNA methylation in peripheral blood mononuclear cells from patients with vitiligo. Br J Dermatol Oct 2010, 163(4):736-742.
    • (2010) Br J Dermatol , vol.163 , Issue.4 , pp. 736-742
    • Zhao, M.1    Gao, F.2    Wu, X.3    Tang, J.4    Lu, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.