An early report on outcomes from computed tomographic-based high-dose-rate brachytherapy for locally advanced cervix cancer: A single institution experience

Practical Radiation Oncology

Volumn 1, Issue 3, 2011, Pages 173-181

  Hallock, Abhirami ^a   Surry, Kathleen ^a   Batchelar, Deidre ^b   VanderSpek, Lauren ^b,c   Yuen, Jasper ^c   Hammond, Alex ^a   Radwan, John ^d   Yaremko, Brian ^a   Rodrigues, George ^a   D'Souza, David ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^c Providence Saint Joseph Medical Center   (United States)

^d Peel Regional Cancer Program   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; FLUOROURACIL; GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BRACHYTHERAPY; CANCER CONTROL; COLON OBSTRUCTION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HEMICOLECTOMY; HUMAN; LASER COAGULATION; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; RECTUM HEMORRHAGE; RETROSPECTIVE STUDY; TREATMENT OUTCOME; TREATMENT PLANNING; TUMOR VOLUME; UTERINE CERVIX CANCER;

EID: 79960125000     PISSN: 18798500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prro.2011.01.004     Document Type: Article

References (38)

1. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 1999, 340:1137-1143.
2. Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 1999, 17:1339-1348.
3. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 1999, 340:1144-1153.
4. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy or bulky stage 1B cervical carcinoma. N Engl J Med 1999, 340:1154-1161.
5. Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC). Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database of Systematic Reviews 2010, (Issue 1).
6. Gerbaulet A, Potter R, Haie-Meder C Cervix cancer. GEC ESTRO handbook of brachytherapy 2002, 301-363. Brussels, Belgium: ESTRO. A. Gerbaulet, R. Potter, J.J. Mazeron (Eds.).
7. Choy D, Wong LC, Sham J, Ngan HY, Ma HK Dose-tumor response of carcinoma of cervix: an analysis of 594 patients treated by radiotherapy. Gynecol Oncol 1993, 49:311-317.
8. Eifel PJ, Thoms WW, Smith TL, Morris M, Oswald MJ The relationship between brachytherapy dose and outcome in patients with bulky endocervical tumors treated with radiation alone. Int J. Radiat Oncol Biol Phys 1994, 28:113-118.
9. Ito H, Kutuki S, Nishiguchi I, et al. Radiotherapy for cervical cancer with high-dose rate brachytherapy correlation between tumor size, dose and failure. Radiother Oncol 1994, 31:240-247.
10. Souhami L, Seymour R, Roman TN, et al. Weekly cisplatin plus external beam radiotherapy and high dose rate brachytherapy in patients with locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 1993, 27:871-878.
11. Haie-Meder C, Pötter R, Van Limbergen E, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of gross tumor volume GTV and CTV. Radiother Oncol 2005, 74:235-245.
12. Pötter R, Haie-Meder C, Van Limbergen E, et al. Recommendations from Gynaecological (GYN)GEC-ESTRO Working Group (II): concepts and terms in 3D image based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image based anatomy, radiation physics, radiobiology. Radiother Oncol 2006, 78:67-77.
13. Nag S Controversies and new development in gynecologic brachytherapy: image-based intracavitary brachytherapy for cervical carcinoma. Semin Radiat Oncol 2006, 16:164-167.
14. Tan LT, Coles CE, Hart C, Tait E Clinical impact of computed tomography-based image-guided brachytherapy for cervix cancer using the tandem ring applicator-the Addenbrooke's Experience. Clin Oncol 2009, 21:175-182.
15. Potter R, Dimopoulos J, Georg P, et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol 2007, 83:148-155.
16. Wachter-Gerstner N, Wachter S, Reinstadler E, Fellner C, Knocke TH, Pötter R The impact of sectional imaging on dose escalation in endocavitary HDR-brachytherapy: results of a prospective comparative trial. Radiother Oncol 2003, 68:51-59.
17. Viswanathan AN, Dimopoulos J, Kirisits C, Berger D, Pötter R Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trail and preliminary guidelines for standardized contours. Int J Radiat Oncol Biol Phys 2007, 68:491-498.
18. Davidson MR, Yuen J, D'Souza DP, et al. Optimization of high dose rate cervix brachytherapy applicator placement: the benefits of intraoperative ultrasound guidance. Brachytherapy 2008, 7:248-253.
19. International Commission of Radiological Units and Measurements ICRU Report 38. Dose and volume specification for intracavitary therapy in gynecology 1985, ICRU, Bethesda, MD.
20. Joiner MC, Bentzen SM Time-dose relationships: the linear quadratic approach. Basic clinical radiobiology 2002, 120-133. Edward Arnold, London. 3rd ed. G.G. Steel (Ed.).
21. Lang S, Kirisits C, Dimopoulos J, Georg D, Pötter R Treatment planning for MRI assisted brachytherapy of gynecologic malignancies based on total dose constraints. Int J Radiat Oncol Biol Phys 2007, 69:619-627.
22. Cancer Therapy Evaluation Program, Common Toxicity Criteria for Adverse Events, Version 3. Available at Accessed March 1. http://ctep.cancer.gov.
23. Kirisits C, Lang S, Dimopoulos J, Oechs K, Georg D, Pötter R Uncertainties when using only one MRI-based treatment plan for subsequent high-dose-rate tandem and ring applications in brachytherapy of cervix cancer. Radiother Oncol 2006, 81:269-275.
24. Pearcey R, Brundage M, Drouin P, et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 2002, 20:966-972.
25. Pötter R, Van Limbergen E, Gerstner N, Wambersie A Survey of the use of the ICRU 38 in recording and reporting cervical cancer brachytherapy. Radiother Oncol 2001, 58:11-18.
26. Datta NR, Srivastava A, Maria Das KJ, Gupta A, Rastogi N Comparative assessment of doses to tumor, rectum, and bladder as evaluated by orthogonal radiographs vs. computer enhanced computed tomography based Intracavitary brachytherapy in cervical cancer. Brachytherapy 2006, 5:223-229.
27. Hunter RD, Wong F, Moore C, Notley HM, Wilkinson J Bladder base dosage in patients undergoing Intracavitary therapy. Radiother Oncol 1986, 7:189-197.
28. Fellner C, Pötter R, Knocke TH, Wambersie A Comparison of radiography and computed tomography based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects. Radiother Oncol 2001, 58:53-62.
29. Katz A, Eifel PJ Quantification of Intracavitary brachytherapy parameters and correlation with outcome in patients with carcinoma of the cervix. Int J Radiat Oncol Biol Phys 2000, 48:1417-1425.
30. Montana GS, Fowler WC Carcinoma of the cervix: analysis of bladder and rectal radiation dose and complications. Int J Radiat Oncol Biol Phys 1989, 16:95-100.
31. EMBRACE clinical trial Available at, Accessed January 1. http://www.embracestudy.dk/.
32. Kim R, Shen S, Duan J Image-based three-dimensional treatment planning of Intracavitary brachytherapy for cancer of the cervix: dose-volume histograms of the bladder, rectum, sigmoid colon and small bowel. Brachytherapy 2007, 6:187-194.
33. Pelloski CE, Palmer M, Chronowski GM, Jhingran A, Horton J, Eifel PJ Comparison between CT based volumetric calculations and ICRU reference point estimates of radiation doses delivered to bladder and rectum during intracavitary radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys 2005, 62:131-137.
34. Yaparpalvi R, Mutyala S, Goral GR, et al. Point vs. volumetric bladder and rectal doses in combined intracavitary-interstitial high dose rate brachytherapy: correlation and comparison with published Vienna applicator data. Brachytherapy 2008, 7:336-342.
35. Georg P, Kirisitis C, Hammer H, et al. Correlation of dose volume parameters, rectoscopy findings and rectal side effects in cervix cancer patients treated with definitive radiotherapy including MRI-based brachytherapy. Brachytherapy 2006, 5:81-82.
36. Koom WS, Sohn DK, Kim JY, et al. Computed tomography based high dose rate Intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Int J Radiat Oncol Biol Phys 2007, 68:1446-1454.
37. Viswanathan A, Erickson B Three-dimensional imaging in gynecologic brachytherapy: a survey of the American Brachytherapy Society. Int J Radiat Oncol Biol Phys 2010, 76:104-109.
38. Wang B, Kwon A, Zhu Y, Yeo I, Henson CF Image-guided intracavitary high-dose-rate brachytherapy for cervix cancer: a single institutional experience with three-dimensional CT-based planning. Brachytherapy 2009, 8:240-247.