Formulation and evaluation of metformin HCL microspheres

International Journal of Pharmacy and Technology

Volumn 3, Issue 2, 2011, Pages 2228-2247

  Reddy, Kishore Kumar K ^a   Rao, Narasimha R ^a   Babu, Jagadeesh Babu V ^a   Reddy, Chandrasheker A ^a  

^a Hits College of Pharmacy   (India)

Author keywords

Ethyl cellulose; Metformin; Microspheres; Solvent evaporation

Indexed keywords

BIOMATERIAL; ETHYL CELLULOSE; METFORMIN; MICROSPHERE; WATER;

ARTICLE; BIODEGRADATION; COACERVATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EXCRETION; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHILICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROENCAPSULATION; PARTICLE SIZE; POLYMERIZATION; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING;

EID: 79960112758     PISSN: None     EISSN: 0975766X     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Williams DA, Lemke TL, Williams L. Insulin and Oral Hypoglyecemic drugs. In: Foyés Principles of Medicinal Chemistry. 5th ed. New York: Lippincott Williams and Wilkins; 2002. p.641-648.
2. Stepensky D, Friedman M, Srour W, Raz I, Hoffman A. Preclinical evaluation of pharmacokinetic- pharmacodynamic rationale for oral CR metformin formulation. J Control Rel 2001; 71:107-115,.
3. Noel M. Kinetic study of normal and sustained release dosage forms of metformin in normalsubjects. J Int Biomed Data 1980; 1:9-20,
4. Pentikainen P. Bioavailability of metformin. Comparison of solution, rapidly dissolving tablet, andthree sustained release products. Int J Clin Pharmacol Ther Toxicol 1986; 24 (4): 213-220.
5. Yuen KH, Peh KK, Tan BL. Relating in vitro/ in vivo data of two controlled release metformin formulations. Drug Dev Ind Pharm 1999; 25 (5): 613-618.
6. Fujioka K,Ledger G,Stevens J,Goyvaerts H,Jamoul C,Stein P. Once daily dosing of metformin extended release (Met-XR) formulation: effects on glycemic control in patients with type 2 diabetes currently treated with metformin, In: American Diabetes Association, 60th Scientific Sessions, San Antonio, Texas, 2000.
7. Gusler G,Berner B. Metformin (GR) gastric retentive tablets: GI transit and pharmacokinetics in healthy volunteers, In: Millennial World Congress of Pharmaceutical Science, San Francisco, California, 2000. Metformin info (www.Rxlist.com; accessed 5/10/2005).
8. Vidon N,Chaussade S,Noel M,Franchisseur C,Huchet BBernier JJ. Metformin in the digestive tract. Diabetes Res Clin Pract 1998; 4:223-229.
9. Marathe PH,Wen Y Norton J,Greene DS,Barbhaiya RH,Wilding IR. Effect of altered gastric emptying and gastrointestinal motility on bioavailability of metformin, in: AAPS Annual Meeting, New Orleans, LA, 1999.
10. El-Kamel AH,Sokar MS,Al Gamal SS,Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm 2001; 220:13-21.
11. Iannuccelli V,Coppi G,Bernabei MT,Cameroni R. Air compartment multiple-unit system for prolonged gastric residence. Part I. Formulation study. Int J Pharm 1998; 174:47-54.
12. Acikgoz M,Kas HS,Hascelik Z,Milli U,Hincal AA. Chitosan microspheres of diclofenac sodium, II: In vitro and in vivo evaluation. Pharmazie 1995; 50:275-77.
13. Thanoo BC,Sunny MC,Jayakrishna A. Oral sustained -release drug delivery system using polycarbonate microspheres capable of floating on the gastric fluid. J Pharm Pharmacol 1993; 45:21-24.
14. Streubel A,Siepmann J,Bodmeier R. Floating microparticles based on low density foam powder.Int J Pharm 2002; 241:279-292.
15. Streubel A,Siepmann J,Bodmeier R. Multiple unit gastroretentive drug delivery systems: a new preparation method for low-density microparticles. J Microencapsulation 2003; 20 (3):329-347.
16. Jayanthi G,Jayaswal SB,Srivastava AK. Formulation and evaluation of terfenadine microballoons for oral controlled release. Pharmazie 1995; 50:769-770.
17. Sato Y,Kawashima Y,Takeuchi H,Yamamoto H. In vivo evaluation of riboflavin-containing microballoons for floating controlled drug delivery system in healthy human volunteers. J Control Rel 93:39-47, 2003.
18. Deasy PB. Microencapsulation and related drug processes. Marcel Dekker Inc; 1984
19. Benita S. Microencapsulation: methods and industrial applications. Vol. 73, Mercel Dekker, Inc.;1996.Patel et al 64
20. Rao KR,Senapati P,Das MK. Formulation and in vitro evaluation of ethyl cellulose microspheres containing zidovudine. J Microencapsul 2005; 22(8): 863-876.
21. Srivastava AK,Ridhurkar DN,Wadha S. floating microspheres of cimetidine: formulation,characterization and in vitro evaluation. Acta Pharm 2005; 55(3): 277-285.
22. Wu PC,Huang YB,Chang JI,Tsai MJ,Tsai YH. Preparation and evaluation of sustained release microspheres of potassium chloride preapred with ethylcellulose. Int J Pharm 2003; 260(1):115- 121.
23. Dinarvand R,Mirfattahi s,Atyabi F. Preparation, characterization and in vitro drug release of isosorbide dinitrate microspheres. J Microencapsul 2002; 19(1): 73-81.
24. Ray S,Ghosh PK,Das B,Ghosh LK,Gupta BK. Statistical optimization supported product development of anti-asthamatic multiparticulate drug delivery system. Indian J Pharm Sci 2000; 62(3): 175-80.