A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins

mAbs

Volumn 3, Issue 4, 2011, Pages 402-407

  Yuan, Tingting ^a   Li, Jingjing ^a   Zhang, Mei Yun ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Antibody; Germline; HIV; Immune responses; Vaccine

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY B12; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; IMMUNOGLOBULIN LIGHT CHAIN; VIRUS ENVELOPE PROTEIN;

ANTIGEN BINDING; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; POINT MUTATION; SOMATIC MUTATION; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; CELL STRAIN HEK293; CHEMISTRY; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; SERODIAGNOSIS;

AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENES, IMMUNOGLOBULIN; HEK293 CELLS; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; POINT MUTATION;

EID: 79960080243     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.3.4.15740     Document Type: Article

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