The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines;Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri

Turkish Journal of Pharmaceutical Sciences

Volumn 8, Issue 2, 2011, Pages 105-116

  Akalin, GÜlşen ^a   Incesu, Zerrin ^a  

^a ANADOLU UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Cancer; Carvacrol; Cell culture; H ras; N ras

Indexed keywords

CARVACROL; CELL DNA; PHOSPHATIDYLSERINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CELL STRUCTURE; CELL TRANSFORMATION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DNA LADDERING; DRUG SENSITIVITY; DRUG STRUCTURE; FLOW CYTOMETRY; IC 50; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE N RAS;

EID: 79960076841     PISSN: 1304530X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Wyllie A.H., "Apoptosis and the regulation of cell numbers in normal and neoplastic tissues" Cancer Metas. Rev., 11, 95-103, 1992.
2. Reader S., Moutardier V., Denizeau F., "Tributyltin triggers apoptosis in trout hepatocytes: the role of Ca2+ protein kinase C and proteases" Biochim. Biophys. Acta., 1448, 473-485, 1998.
3. McConkey D.J., Nicotera P., Hartzell P., Bellomo G., Orrenius A.H.S., "Glucocorticoid activates a suicide process in oocytes through an elevation of cytosolic Ca++ concentration" J. Biochem. Biophys., 269, 365-370, 1989.
4. Li J., Eastman A., "Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na+/H+-antiport" J. Biol. Chem., 270, 3203-3211, 1995.
5. Vermes I., Haanen C., Steffens N.H., Reutelingsperger C., "A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V" J. Immunol. Met., 184, 39-41, 1995.
6. Wyllie A.H., "Glucocorticoid-induced thymocyte apoptosis in associated with endogenous endonuclease activation" Nature, 84, 555-566, 1981.
7. Takano Y., Okudaira M., Harmon B.V., "Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate" Pathol. Res. Pract., 189, 197-203, 1993.
8. Horváth G., Kocsis B., Botz L., Nemeth J., Szabó L., "Antibacterial activity of thymus phenols by direct bioautography" Acta. Bio. Szegediensis, 46, 145-156, 2002.
9. Ultee A., Smid E.J., "Influenze of carvacrol on growth and toxin production by Bacillus cereus" Int. J. Food Microbiol., 64, 373-378, 2001.
10. Karaman S., Digrak M., Ravid U., Ilcim A., "Antibacterial and antifungal activity of the essential oils of thymus revolutus celak from Turkey" J. Ethnopharmacol., 76, 183-186, 2001.
11. Karpouhtsis I., Pardali E., Feggou E., Kokkini S., Scouras Z.G., Mavragani T.P., "Insectisidal and genotoxic activities of oregano essential oils" J. Agric. Food Chem., 46, 1111-1115, 1998.
12. Tepe B., Sökmen M., Akbulut H.A., Daferera D., Polissiou M., "Antioxidative activity of the essential oils of Thymus sipyleus subsp. Sipyleus var. Sipyleus and Thymus sipyleus subsp. Sipyleus var. Rosulans" J. Food Eng., 66, 447-454, 2005.
13. Stammati A., Bonsi P., Zucco F., Moezelaar R., Alakomi H.L., Wright A.V., "Toxicity of selected plant volatiles in microbial and mammalian short-therm assays" Food Chem. Toxicol., 37, 813-823, 1999.
14. Aydi{dotless}n S., Başaran A.A., Başaran N., "The effects of thyme volites on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C" Mutation Res., 581, 43-53, 2005.
15. Zeytinoǧlu H., Incesu Z., Baser K.H.C., "Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-ras oncogene" Phytomed., 10, 292-299, 2003.
16. Gossett L.A., Zhang W., Olson E., "Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogene" J. Cell Biol., 106, 2127-2137, 1998.
17. Gerhart J., Bast B., Neely C., Iem S., Amegbe P., Niewenhuis R., Miklasz S., Cheng F., George-Weinstein M., "Myod-positive myoblasts are present in mature fetal organs lacking skeletal muscle" J. Cell Biol., 155, 381-392, 2001.
18. Jiang B., Liu Y., Bao M., An L.J., "Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin" Cell Biol. Int., 27, 1025-1031, 2003.
19. Mossmann T., "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays" J. Immunol. Met., 65, 55-63, 1983.
20. Agostino D.P., Ferlazzo V., Milano S., "Chemically modified tetracyclines induce cytotoxic effects against J774 tumour cell line by activating the apoptotic pathway" Int. Immunol., 3, 63-67, 2003.
21. Crowell P.L., "Prevention and therapy of cancer by dietary monoterpensc" J. Nutr., 69, 25-29, 1999.
22. Adany I., Yazlovitskaya E.M., Haug J.S., Voziyan P.A., Melnykovych G., "Differences in sensitivity to farnesol toxicity between neoplastically-and non-neoplastically-derived cells in culture" Cancer Lett., 79, 175-179, 1994.
23. He L., Mo H., Hadissusilu S., Quresni A.A., Elson C.E., "Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo" Biochem. Mol. J. Nutr., 127, 668-674, 1997.
24. Zeytinoǧlu M., Aydin S., Oztürk Y., Baser K.H.C., "Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats" Acta. Pharma. Turcica, 2, 93-98, 1998.
25. Yanishlieva N.V., Marinova E.M., Gordon M.H., Raneva V.G., "Antioxidant activity and mechanism of action of thymol and carvacrol in two lipid systems" Food Chem., 64, 59-66, 1999.