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Volumn 65, Issue SUPPL. 172, 2011, Pages 35-43

Transforming growth factor signalling: A common pathway in pulmonary arterial hypertension and systemic sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR;

EID: 79960076306     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2011.02726.x     Document Type: Review
Times cited : (10)

References (84)
  • 1
    • 67649579669 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G, Robbins IM, Beghetti M, et al., Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2009; 54 (Suppl. 1): S43-54.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.SUPPL. 1
    • Simonneau, G.1    Robbins, I.M.2    Beghetti, M.3
  • 2
    • 64849109410 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; And the Pulmonary Hypertension Association
    • McLaughlin VV, Archer SL, Badesch DB, et al., ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol 2009; 53: 1573-619.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1573-1619
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 3
    • 0027200632 scopus 로고
    • Primary pulmonary hypertension
    • Rubin LJ,. Primary pulmonary hypertension. Chest 1993; 104: 236-50. (Pubitemid 23204564)
    • (1993) Chest , vol.104 , Issue.1 , pp. 236-250
    • Rubin, L.J.1
  • 4
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM, et al., Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991; 115: 343-9.
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 6
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J,. Pulmonary arterial hypertension. N Engl J Med 2004; 351: 1655-65.
    • (2004) N Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 8
    • 0029166752 scopus 로고
    • Different distribution of plexiform lesions in primary and secondary pulmonary hypertension
    • Jamison BM, Michel RP,. Different distribution of plexiform lesions in primary and secondary pulmonary hypertension. Hum Pathol 1995; 26: 987-93.
    • (1995) Hum Pathol , vol.26 , pp. 987-993
    • Jamison, B.M.1    Michel, R.P.2
  • 9
    • 69249145284 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: A distinctive vasculopathy
    • Overbeek MJ, Vonk MC, Boonstra A, et al., Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: a distinctive vasculopathy. Eur Respir J 2009; 34: 371-9.
    • (2009) Eur Respir J , vol.34 , pp. 371-379
    • Overbeek, M.J.1    Vonk, M.C.2    Boonstra, A.3
  • 12
    • 0026533596 scopus 로고
    • Mortality in systemic sclerosis (scleroderma)
    • Lee P, Langevitz P, Alderdice CA, et al., Mortality in systemic sclerosis (scleroderma). Q J Med 1992; 82: 139-48.
    • (1992) Q J Med , vol.82 , pp. 139-148
    • Lee, P.1    Langevitz, P.2    Alderdice, C.A.3
  • 13
    • 61349189063 scopus 로고    scopus 로고
    • Risk factors for death and the 3-year survival of patients with systemic sclerosis: The French ItinerAIR-Sclerodermie study
    • Hachulla E, Carpentier P, Gressin V, et al., Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French ItinerAIR-Sclerodermie study. Rheumatology (Oxford) 2009; 48: 304-8.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 304-308
    • Hachulla, E.1    Carpentier, P.2    Gressin, V.3
  • 14
    • 3142692425 scopus 로고    scopus 로고
    • Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • DOI 10.1378/chest.126.1-suppl.14S
    • McGoon M, Gutterman D, Steen V, et al., Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004; 126 (Suppl. 1): 14S-34S. (Pubitemid 38932340)
    • (2004) Chest , vol.126 , Issue.SUPPL. 1
    • McGoon, M.1    Gutterman, D.2    Steen, V.3    Barst, R.4    McCrory, D.C.5    Fortin, T.A.6    Loyd, J.E.7
  • 15
    • 76749135710 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Baseline characteristics from the REVEAL Registry
    • Badesch DB, Raskob GE, Elliott CG, et al., Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest 2010; 137: 376-87.
    • (2010) Chest , vol.137 , pp. 376-387
    • Badesch, D.B.1    Raskob, G.E.2    Elliott, C.G.3
  • 16
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension. A national prospective study
    • Rich S, Dantzker DR, Ayres SM, et al., Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216-23. (Pubitemid 17137857)
    • (1987) Annals of Internal Medicine , vol.107 , Issue.2 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 20
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • Lane KB, Machado RD, Pauciulo MW, et al., Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 2000; 26: 81-4.
    • (2000) Nat Genet , vol.26 , pp. 81-84
    • Lane, K.B.1    MacHado, R.D.2    Pauciulo, M.W.3
  • 22
    • 77955880114 scopus 로고    scopus 로고
    • Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment
    • Shovlin CL,. Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev 2010; 24: 203-19.
    • (2010) Blood Rev , vol.24 , pp. 203-219
    • Shovlin, C.L.1
  • 24
    • 32544438253 scopus 로고    scopus 로고
    • BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension
    • Aldred MA, Vijayakrishnan J, James V, et al., BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Hum Mutat 2006; 27: 212-3.
    • (2006) Hum Mutat , vol.27 , pp. 212-213
    • Aldred, M.A.1    Vijayakrishnan, J.2    James, V.3
  • 25
    • 0033623296 scopus 로고    scopus 로고
    • Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family
    • Thomson JR, Machado RD, Pauciulo MW, et al., Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. J Med Genet 2000; 37: 741-5.
    • (2000) J Med Genet , vol.37 , pp. 741-745
    • Thomson, J.R.1    MacHado, R.D.2    Pauciulo, M.W.3
  • 27
    • 67649573380 scopus 로고    scopus 로고
    • Genetics and genomics of pulmonary arterial hypertension
    • Machado RD, Eickelberg O, Elliott CG, et al., Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol 2009; 54 (Suppl. 1): S32-42.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.SUPPL. 1
    • MacHado, R.D.1    Eickelberg, O.2    Elliott, C.G.3
  • 29
    • 33845942152 scopus 로고    scopus 로고
    • Is methamphetamine use associated with idiopathic pulmonary arterial hypertension?
    • DOI 10.1378/chest.130.6.1657
    • Chin KM, Channick RN, Rubin LJ,. Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest 2006; 130: 1657-63. (Pubitemid 46033416)
    • (2006) Chest , vol.130 , Issue.6 , pp. 1657-1663
    • Chin, K.M.1    Channick, R.N.2    Rubin, L.J.3
  • 30
    • 0020564431 scopus 로고
    • An epidemic of pulmonary hypertension after toxic rapeseed oil ingestion in Spain
    • Garcia-Dorado D, Miller DD, Garcia EJ, Delcan JL, Maroto E, Chaitman BR,. An epidemic of pulmonary hypertension after toxic rapeseed oil ingestion in Spain. J Am Coll Cardiol 1983; 1: 1216-22. (Pubitemid 13059015)
    • (1983) Journal of the American College of Cardiology , vol.1 , Issue.5 , pp. 1216-1222
    • Garcia Dorado, D.1    Miller, D.D.2    Garcia, E.J.3
  • 32
    • 37049011872 scopus 로고    scopus 로고
    • Genetic basis for systemic sclerosis
    • DOI 10.1016/j.jbspin.2007.04.005, PII S1297319X07001960
    • Allanore Y, Wipff J, Kahan A, Boileau C,. Genetic basis for systemic sclerosis. Joint Bone Spine 2007; 74: 577-83. (Pubitemid 350245624)
    • (2007) Joint Bone Spine , vol.74 , Issue.6 , pp. 577-583
    • Allanore, Y.1    Wipff, J.2    Kahan, A.3    Boileau, C.4
  • 34
    • 3543135630 scopus 로고
    • Epidemiology of progressive systemic sclerosis in Japan
    • Black C.M., Myers A.R., eds. New York: Gower.
    • Shinkai H,. Epidemiology of progressive systemic sclerosis in Japan. In:, Black CM, Myers AR, eds. Progressive Systemic Sclerosis (Current Topics in Rheumatology). New York: Gower, 1985: 79-81.
    • (1985) Progressive Systemic Sclerosis (Current Topics in Rheumatology) , pp. 79-81
    • Shinkai, H.1
  • 36
    • 0025412109 scopus 로고
    • Geographical clustering of scleroderma in south and west London
    • Silman AJ, Howard Y, Hicklin AJ, Black C,. Geographical clustering of scleroderma in south and west London. Br J Rheumatol 1990; 29: 93-6.
    • (1990) Br J Rheumatol , vol.29 , pp. 93-96
    • Silman, A.J.1    Howard, Y.2    Hicklin, A.J.3    Black, C.4
  • 37
    • 0242495083 scopus 로고    scopus 로고
    • Examination of the possible role of biologically relevant genes around FBN1 in systemic sclerosis in the Choctaw population [1]
    • DOI 10.1002/art.11280
    • Tan FK, Tercero GM, Arnett FC, Wang N, Chakraborty R,. Examination of the possible role of biologically relevant genes around FBN1 in systemic sclerosis in the Choctaw population. Arthritis Rheum 2003; 48: 3295-6. (Pubitemid 37409346)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.11 , pp. 3295-3296
    • Tan, F.K.1    Tercero, G.M.2    Arnett, F.C.3    Wang, N.4    Chakraborty, R.5
  • 38
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • DOI 10.1002/art.21948
    • Wang Y, Fan PS, Kahaleh B,. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 2006; 54: 2271-9. (Pubitemid 44051084)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.7 , pp. 2271-2279
    • Wang, Y.1    Fan, P.-S.2    Kahaleh, B.3
  • 39
    • 70450173918 scopus 로고    scopus 로고
    • Systemic sclerosis: Environmental factors
    • Mora GF,. Systemic sclerosis: environmental factors. J Rheumatol 2009; 36: 2383-96.
    • (2009) J Rheumatol , vol.36 , pp. 2383-2396
    • Mora, G.F.1
  • 42
    • 0026676557 scopus 로고
    • What is the contribution of occupational environmental factors to the occurrence of scleroderma in men?
    • Silman AJ, Jones S,. What is the contribution of occupational environmental factors to the occurrence of scleroderma in men? Ann Rheum Dis 1992; 51: 1322-4. (Pubitemid 23000069)
    • (1992) Annals of the Rheumatic Diseases , vol.51 , Issue.12 , pp. 1322-1324
    • Silman, A.J.1    Jones, S.2
  • 43
    • 0346727461 scopus 로고    scopus 로고
    • Following the Molecular Pathways toward an Understanding of the Pathogenesis of Systemic Sclerosis
    • Jimenez SA, Derk CT,. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med 2004; 140: 37-50. (Pubitemid 38055920)
    • (2004) Annals of Internal Medicine , vol.140 , Issue.1 , pp. 37-50
    • Jimenez, S.A.1    Derk, C.T.2
  • 44
    • 0034965980 scopus 로고    scopus 로고
    • Familial occurrence frequencies and relative risks for systemic sclerosis (Scleroderma) in three United States cohorts
    • DOI 10.1002/1529-0131(200106)4 4:6<1359::AID-ART228>3.0.CO;2-S
    • Arnett FC, Cho M, Chatterjee S, Aguilar MB, Reveille JD, Mayes MD,. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum 2001; 44: 1359-62. (Pubitemid 32537534)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.6 , pp. 1359-1362
    • Arnett, F.C.1    Cho, M.2    Chatterjee, S.3    Aguilar, M.B.4    Reveille, J.D.5    Mayes, M.D.6
  • 46
    • 77954239390 scopus 로고    scopus 로고
    • Heritability of vasculopathy, autoimmune disease, and fibrosis in systemic sclerosis: A population-based study
    • Frech T, Khanna D, Markewitz B, Mineau G, Pimentel R, Sawitzke A,. Heritability of vasculopathy, autoimmune disease, and fibrosis in systemic sclerosis: a population-based study. Arthritis Rheum 2010; 62: 2109-16.
    • (2010) Arthritis Rheum , vol.62 , pp. 2109-2116
    • Frech, T.1    Khanna, D.2    Markewitz, B.3    Mineau, G.4    Pimentel, R.5    Sawitzke, A.6
  • 47
    • 0038004795 scopus 로고    scopus 로고
    • Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies
    • DOI 10.1002/art.11173
    • Feghali-Bostwick C, Medsger TA Jr, Wright TM,. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum 2003; 48: 1956-63. (Pubitemid 36828691)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.7 , pp. 1956-1963
    • Feghali-Bostwick, C.1    Medsger Jr., T.A.2    Wright, T.M.3
  • 48
    • 26844493324 scopus 로고    scopus 로고
    • Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles
    • DOI 10.1002/art.21355
    • Zhou X, Tan FK, Xiong M, Arnett FC, Feghali-Bostwick CA,. Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles. Arthritis Rheum 2005; 52: 3305-14. (Pubitemid 41447114)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.10 , pp. 3305-3314
    • Zhou, X.1    Tan, F.K.2    Xiong, M.3    Arnett, F.C.4    Feghali-Bostwick, C.A.5
  • 50
    • 0035052163 scopus 로고    scopus 로고
    • Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations
    • DOI 10.1002/1529-0131(200104) 44:4<893::AID-ANR146>3.0.CO;2-3
    • Tan FK, Wang N, Kuwana M, et al., Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations. Arthritis Rheum 2001; 44: 893-901. (Pubitemid 32319782)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.4 , pp. 893-901
    • Tan, F.K.1    Wang, N.2    Kuwana, M.3    Chakraborty, R.4    Bona, C.A.5    Milewicz, D.M.6    Arnett, F.C.7
  • 51
    • 0034881850 scopus 로고    scopus 로고
    • Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma)
    • DOI 10.1002/1529-0131(200108) 44:8<1855::AID-ART324>3.0.CO;2-Q
    • Wallis DD, Tan FK, Kielty CM, Kimball MD, Arnett FC, Milewicz DM,. Abnormalities in fibrillin 1-containing microfibrils in dermal fibroblast cultures from patients with systemic sclerosis (scleroderma). Arthritis Rheum 2001; 44: 1855-64. (Pubitemid 32758234)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.8 , pp. 1855-1864
    • Wallis, D.D.1    Tan, F.K.2    Kielty, C.M.3    Kimball, M.D.4    Arnett, F.C.5    Milewicz, D.M.6
  • 53
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor beta as a therapeutic target in systemic sclerosis
    • Varga J, Pasche B,. Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol 2009; 5: 200-6.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 54
    • 68049112537 scopus 로고    scopus 로고
    • STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis
    • Dieude P, Guedj M, Wipff J, et al., STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Arthritis Rheum 2009; 60: 2472-9.
    • (2009) Arthritis Rheum , vol.60 , pp. 2472-2479
    • Dieude, P.1    Guedj, M.2    Wipff, J.3
  • 55
    • 0036844311 scopus 로고    scopus 로고
    • Pulmonary hypertension in scleroderma spectrum of disease: Lack of bone morphogenetic protein receptor 2 mutations
    • Morse J, Barst R, Horn E, Cuervo N, Deng Z, Knowles J,. Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations. J Rheumatol 2002; 29: 2379-81. (Pubitemid 35266029)
    • (2002) Journal of Rheumatology , vol.29 , Issue.11 , pp. 2379-2381
    • Morse, J.1    Barst, R.2    Horn, E.3    Cuervo, N.4    Deng, Z.5    Knowles, J.6
  • 56
    • 0036822548 scopus 로고    scopus 로고
    • Mutations of bone morphogenetic protein receptor type II are not found in patients with pulmonary hypertension and underlying connective tissue diseases [6]
    • DOI 10.1002/art.10487
    • Tew MB, Arnett FC, Reveille JD, Tan FK,. Mutations of bone morphogenetic protein receptor type II are not found in patients with pulmonary hypertension and underlying connective tissue diseases. Arthritis Rheum 2002; 46: 2829-30. (Pubitemid 36118956)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.10 , pp. 2829-2830
    • Tew, M.B.1    Arnett, F.C.2    Reveille, J.D.3    Tan, F.K.4
  • 57
    • 34250768373 scopus 로고    scopus 로고
    • Mutations of activin-receptor-like kinase 1 (ALK-1) are not found in patients with pulmonary hypertension and underlying connective tissue disease
    • DOI 10.1007/s10067-006-0388-x
    • Selva-O'Callaghan A, Balada E, Serrano-Acedo S, Simeon Aznar CP, Ordi-Ros J,. Mutations of activin-receptor-like kinase 1 (ALK-1) are not found in patients with pulmonary hypertension and underlying connective tissue disease. Clin Rheumatol 2007; 26: 947-9. (Pubitemid 46951295)
    • (2007) Clinical Rheumatology , vol.26 , Issue.6 , pp. 947-949
    • Selva-O'Callaghan, A.1    Balada, E.2    Serrano-Acedo, S.3    Simeon Aznar, C.P.4    Ordi-Ros, J.5
  • 58
    • 35048875855 scopus 로고    scopus 로고
    • TGF-beta signaling: A tale of two responses
    • DOI 10.1002/jcb.21501
    • Rahimi RA, Leof EB,. TGF-beta signaling: a tale of two responses. J Cell Biochem 2007; 102: 593-608. (Pubitemid 47557414)
    • (2007) Journal of Cellular Biochemistry , vol.102 , Issue.3 , pp. 593-608
    • Rahimi, R.A.1    Leof, E.B.2
  • 59
    • 67650657499 scopus 로고    scopus 로고
    • Interleukin-17 and systemic lupus erythematosus: Current concepts
    • Nalbandian A, Crispin JC, Tsokos GC,. Interleukin-17 and systemic lupus erythematosus: current concepts. Clin Exp Immunol 2009; 157: 209-15.
    • (2009) Clin Exp Immunol , vol.157 , pp. 209-215
    • Nalbandian, A.1    Crispin, J.C.2    Tsokos, G.C.3
  • 60
    • 0028168242 scopus 로고
    • P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon GJ, Beach D,. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 1994; 371: 257-61.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 61
    • 79952202578 scopus 로고    scopus 로고
    • Transforming growth factor-beta: Recent advances on its role in immune tolerance
    • Mantel PY, Schmidt-Weber CB,. Transforming growth factor-beta: recent advances on its role in immune tolerance. Methods Mol Biol 2011; 677: 303-38.
    • (2011) Methods Mol Biol , vol.677 , pp. 303-338
    • Mantel, P.Y.1    Schmidt-Weber, C.B.2
  • 62
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J,. TGF-beta signal transduction. Annu Rev Biochem 1998; 67: 753-91.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 63
    • 0037144841 scopus 로고    scopus 로고
    • TGF beta receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
    • Hayes S, Chawla A, Corvera S,. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol 2002; 158: 1239-49.
    • (2002) J Cell Biol , vol.158 , pp. 1239-1249
    • Hayes, S.1    Chawla, A.2    Corvera, S.3
  • 64
    • 33750069029 scopus 로고    scopus 로고
    • Escaping from the TGFbeta anti-proliferative control
    • Seoane J,. Escaping from the TGFbeta anti-proliferative control. Carcinogenesis 2006; 27: 2148-56.
    • (2006) Carcinogenesis , vol.27 , pp. 2148-2156
    • Seoane, J.1
  • 65
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • DOI 10.1101/gad.1350705
    • Massague J, Seoane J, Wotton D,. Smad transcription factors. Genes Dev 2005; 19: 2783-810. (Pubitemid 41739965)
    • (2005) Genes and Development , vol.19 , Issue.23 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 67
    • 37349113805 scopus 로고    scopus 로고
    • Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis
    • DOI 10.1016/j.jdermsci.2007.05.014, PII S0923181107002046
    • Ihn H,. Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis. J Dermatol Sci 2008; 49: 103-13. (Pubitemid 350298736)
    • (2008) Journal of Dermatological Science , vol.49 , Issue.2 , pp. 103-113
    • Ihn, H.1
  • 68
    • 51449089944 scopus 로고    scopus 로고
    • In perspective: Murine models of scleroderma
    • Wu M, Varga J,. In perspective: murine models of scleroderma. Curr Rheumatol Rep 2008; 10: 173-82.
    • (2008) Curr Rheumatol Rep , vol.10 , pp. 173-182
    • Wu, M.1    Varga, J.2
  • 70
    • 33749320619 scopus 로고    scopus 로고
    • Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma
    • DOI 10.1002/art.22063
    • Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M,. Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma. Arthritis Rheum 2006; 54: 3011-21. (Pubitemid 44497783)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.9 , pp. 3011-3021
    • Pannu, J.1    Gardner, H.2    Shearstone, J.R.3    Smith, E.4    Trojanowska, M.5
  • 71
    • 0035079964 scopus 로고    scopus 로고
    • Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma
    • DOI 10.1002/1529-0131(20010 3)44:3<731::AID-ANR124>3.0.CO;2-U
    • Kubo M, Ihn H, Yamane K, Tamaki K,. Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma. Arthritis Rheum 2001; 44: 731-4. (Pubitemid 32234634)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.3 , pp. 731-734
    • Kubo, M.1    Ihn, H.2    Yamane, K.3    Tamaki, K.4
  • 72
    • 79954906535 scopus 로고    scopus 로고
    • Activation of the Activin A-ALK-Smad pathway in systemic sclerosis
    • Takagi K, Kawaguchi Y, Kawamoto M, et al., Activation of the Activin A-ALK-Smad pathway in systemic sclerosis. J Autoimmun 2011; 36: 181-8.
    • (2011) J Autoimmun , vol.36 , pp. 181-188
    • Takagi, K.1    Kawaguchi, Y.2    Kawamoto, M.3
  • 74
    • 0030854850 scopus 로고    scopus 로고
    • Sp1 is required for the early response of 2(I) collagen to transforming growth factor-beta1
    • DOI 10.1074/jbc.272.32.19738
    • Greenwel P, Inagaki Y, Hu W, Walsh M, Ramirez F,. Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1. J Biol Chem 1997; 272: 19738-45. (Pubitemid 27340064)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.32 , pp. 19738-19745
    • Greenwel, P.1    Inagaki, Y.2    Hu, W.3    Walsh, M.4    Ramirez, F.5
  • 76
    • 0034595653 scopus 로고    scopus 로고
    • Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads
    • DOI 10.1074/jbc.275.22.16709
    • Taylor LM, Khachigian LM,. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads. J Biol Chem 2000; 275: 16709-16. (Pubitemid 30398901)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16709-16716
    • Taylor, L.M.1    Khachigian, L.M.2
  • 77
    • 0036139899 scopus 로고    scopus 로고
    • Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the smad signaling pathway
    • You L, Kruse FE,. Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the Smad signaling pathway. Invest Ophthalmol Vis Sci 2002; 43: 72-81. (Pubitemid 34032443)
    • (2002) Investigative Ophthalmology and Visual Science , vol.43 , Issue.1 , pp. 72-81
    • You, L.1    Kruse, F.E.2
  • 78
    • 0034680856 scopus 로고    scopus 로고
    • Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling
    • Lai CF, Feng X, Nishimura R, et al., Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J Biol Chem 2000; 275: 36400-6.
    • (2000) J Biol Chem , vol.275 , pp. 36400-36406
    • Lai, C.F.1    Feng, X.2    Nishimura, R.3
  • 79
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir I, Polyak K, Iavarone A, Massague J,. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 1995; 9: 1831-45.
    • (1995) Genes Dev , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 80
    • 0027250532 scopus 로고
    • Transforming growth factor beta1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest
    • Reddy KB, Howe PH,. Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest. J Cell Physiol 1993; 156: 48-55. (Pubitemid 23211261)
    • (1993) Journal of Cellular Physiology , vol.156 , Issue.1 , pp. 48-55
    • Reddy, K.B.1    Howe, P.H.2
  • 81
    • 0036735752 scopus 로고    scopus 로고
    • Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
    • DOI 10.1091/mbc.E02-02-0063
    • Nishihara A, Watabe T, Imamura T, Miyazono K,. Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell 2002; 13: 3055-63. (Pubitemid 35034245)
    • (2002) Molecular Biology of the Cell , vol.13 , Issue.9 , pp. 3055-3063
    • Nishihara, A.1    Watabe, T.2    Imamura, T.3    Miyazono, K.4
  • 82
    • 65749097812 scopus 로고    scopus 로고
    • TGF-beta and BMPR-II pharmacology - Implications for pulmonary vascular diseases
    • Upton PD, Morrell NW,. TGF-beta and BMPR-II pharmacology-implications for pulmonary vascular diseases. Curr opin pharmacol 2009; 9: 274-80.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 274-280
    • Upton, P.D.1    Morrell, N.W.2
  • 83
    • 0031106404 scopus 로고    scopus 로고
    • Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
    • DOI 10.1016/S1359-6101(96)00048-2, PII S1359610196000482
    • Pepper MS,. Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 1997; 8: 21-43. (Pubitemid 27214687)
    • (1997) Cytokine and Growth Factor Reviews , vol.8 , Issue.1 , pp. 21-43
    • Pepper, M.S.1
  • 84
    • 69149094674 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling and tumor angiogenesis
    • Pardali E, ten Dijke P,. Transforming growth factor-beta signaling and tumor angiogenesis. Front biosci 2009; 14: 4848-61.
    • (2009) Front Biosci , vol.14 , pp. 4848-4861
    • Pardali, E.1    Ten Dijke, P.2


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