Design and Testing of Regulatory Cassettes for Optimal Activity in Skeletal and Cardiac Muscles

Methods in Molecular Biology

Volumn 709, Issue , 2011, Pages 3-19

  Himeda, Charis L ^a   Chen, Xiaolan ^a   Hauschka, Stephen D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cardiac muscle; Gene therapy; Muscle creatine kinase; Muscular dystrophy; Regulatory cassette; Skeletal muscle; Transcriptional regulation

Indexed keywords

CREATINE KINASE MM;

ADENO ASSOCIATED VIRUS; ARTICLE; ENHANCER REGION; GENE EXPRESSION; GENE THERAPY; GENE VECTOR; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GENETICS; HEART MUSCLE; HUMAN; METABOLISM; MUSCULAR DYSTROPHY; PROMOTER REGION; SKELETAL MUSCLE;

CREATINE KINASE, MM FORM; DEPENDOVIRUS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; MYOCARDIUM; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC;

EID: 79960064622     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61737-982-6_1     Document Type: Chapter

References (64)

1. Salva, M. Z., Himeda, C. L., Tai, P. W., Nishiuchi, E., Gregorevic, P., Allen, J. M., Finn, E. E., Nguyen, Q. G., Blankinship, M. J., Meuse, L., Chamberlain, J. S., and Hauschka, S. D. (2007) Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle. Mol Ther 15, 320–329.
2. Gregorevic, P., Blankinship, M. J., Allen, J. M., Crawford, R. W., Meuse, L., Miller, D. G., Russell, D. W., and Chamberlain, J. S. (2004) Systemic delivery of genes to striated muscles using adeno-associated viral vectors. Nat Med 10, 828–834.
3. Donoviel, D. B., Shield, M. A., Buskin, J. N., Haugen, H. S., Clegg, C. H., and Hauschka, S. D. (1996) Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. Mol Cell Biol 16, 1649–1658.
4. Shield, M. A., Haugen, H. S., Clegg, C. H., and Hauschka, S. D. (1996) E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice. Mol Cell Biol 16, 5058–5068.
5. Hagstrom, J. N., Couto, L. B., Scallan, C., Burton, M., McCleland, M. L., Fields, P. A., Arruda, V. R., Herzog, R. W., and High, K. A. (2000) Improved muscle-derived expression of human coagulation factor IX from a skeletal actin/CMV hybrid enhancer/promoter. Blood 95, 2536–2542.
6. Jerkovic, R., Vitadello, M., Kelly, R., Buckingham, M., and Schiaffino, S. (1997) Fibre type-specific and nerve-dependent regulation of myosin light chain 1 slow promoter in regenerating muscle. J Muscle Res Cell Motil 18, 369–373.
7. Li, X., Eastman, E. M., Schwartz, R. J., and Draghia-Akli, R. (1999) Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences. Nat Biotechnol 17, 241–245.
8. Kelly, R. G., and Buckingham, M. E. (2000) Modular regulation of the MLC1F/3F gene and striated muscle diversity. Microsc Res Tech 50, 510–521.
9. Skarli, M., Kiri, A., Vrbova, G., Lee, C. A., and Goldspink, G. (1998) Myosin regulatory elements as vectors for gene transfer by intramuscular injection. Gene Ther 5, 514–520.
10. Arruda, V. R., Stedman, H. H., Nichols, T. C., Haskins, M. E., Nicholson, M., Herzog, R. W., Couto, L. B., and High, K. A. (2005) Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model. Blood 105, 3458–3464.
11. Su, L. T., Gopal, K., Wang, Z., Yin, X., Nelson, A., Kozyak, B. W., Burkman, J. M., Mitchell, M. A., Low, D. W., Bridges, C. R., and Stedman, H. H. (2005) Uniform scale-independent gene transfer to striated muscle after transvenular extravasation of vector. Circulation 112, 1780–1788.
12. Bridges, C. R., Gopal, K., Holt, D. E., Yarnall, C., Cole, S., Anderson, R. B., Yin, X., Nelson, A., Kozyak, B. W., Wang, Z., Lesniewski, J., Su, L. T., Thesier, D. M., Sundar, H., and Stedman, H. H. (2005) Efficient myocyte gene delivery with complete cardiac surgical isolation in situ. J Thorac Cardiovasc Surg 130, 1364.
13. Amacher, S. L., Buskin, J. N., and Hauschka, S. D. (1993) Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle. Mol Cell Biol 13, 2753–2764.
14. Clegg, C. H., Linkhart, T. A., Olwin, B. B., and Hauschka, S. D. (1987) Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibro-blast growth factor. J Cell Biol 105, 949–956.
15. Neville, C., Rosenthal, N., McGrew, M., Bogdanova, N., and Hauschka, S. (1997) Skeletal muscle cultures. Methods Cell Biol 52, 85–116.
16. Nguyen, Q. G., Buskin, J. N., Himeda, C. L., Fabre-Suver, C., and Hauschka, S. D. (2003) Transgenic and tissue culture analyses of the muscle creatine kinase enhancer Trex control element in skeletal and cardiac muscle indicate differences in gene expression between muscle types. Transgenic Res 12, 337–349.
17. Bischoff, R. (1989) Analysis of muscle regeneration using single myofibers in culture. Med Sci Sports Exerc 21, S164–S172.
18. Bischoff, R. (1990) Interaction between satellite cells and skeletal muscle fibers. Development 109, 943–952.
19. Bischoff, R. (1990) Cell cycle commitment of rat muscle satellite cells. J Cell Biol 111, 201–207.
20. Konigsberg, U. R., Lipton, B. H., and Konigsberg, I. R. (1975) The regenerative response of single mature muscle fibers isolated in vitro. Dev Biol 45, 260–275.
21. Shefer, G., and Yablonka-Reuveni, Z. (2005) Isolation and culture of skeletal muscle myofibers as a means to analyze satellite cells. Methods Mol Biol 290, 281–304.
22. Sternberg, E. A., Spizz, G., Perry, W. M., Vizard, D., Weil, T., and Olson, E. N. (1988) Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. Mol Cell Biol 8, 2896–2909.
23. Johnson, J. E., Wold, B. J., and Hauschka, S. D. (1989) Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice. Mol Cell Biol 9, 3393–3399.
24. Jaynes, J. B., Johnson, J. E., Buskin, J. N., Gartside, C. L., and Hauschka, S. D. (1988) The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer. Mol Cell Biol 8, 62–70.
25. Hauser, M. A., Robinson, A., Hartigan-O’Connor, D., Williams-Gregory, D. A., Buskin, J. N., Apone, S., Kirk, C. J., Hardy, S., Hauschka, S. D., and Chamberlain, J. S. (2000) Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. Mol Ther 2, 16–25.
26. Himeda, C. L. (2003) Identification and Characterization of the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer. University of Washington, Seattle, Washington.
27. Himeda, C. L., Ranish, J. A., Angello, J. C., Maire, P., Aebersold, R., and Hauschka, S. D. (2004) Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol 24, 2132–2143.
28. Himeda, C. L., Ranish, J. A., and Hauschka, S. D. (2008) Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. Mol Cell Biol 28, 6521–6535.
29. Himeda, C. L., Ranish, J. A., Pearson, R. C., Crossley, M., and Hauschka, S. D. (2010) KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites. Mol Cell Biol 30, 3430–3443.
30. Donoghue, M., Ernst, H., Wentworth, B., Nadal-Ginard, B., and Rosenthal, N. (1988) A muscle-specific enhancer is located at the 3¢ end of the myosin light-chain 1/3 gene locus. Genes Dev 2, 1779–1790.
31. Emami, K. H., Jain, A., and Smale, S. T. (1997) Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomer-ization. Genes Dev 11, 3007–3019.
32. Morin, S., Paradis, P., Aries, A., and Nemer, M. (2001) Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. Mol Cell Biol 21, 1036–1044.
33. Apone, S., and Hauschka, S. D. (1995) Muscle gene E-box control elements. Evidence for quantitatively different transcriptional activities and the binding of distinct regulatory factors. J Biol Chem 270, 21420–21427.
34. Larkin, S. B., Farrance, I. K., and Ordahl, C. P. (1996) Flanking sequences modulate the cell specificity of M-CAT elements. Mol Cell Biol 16, 3742–3755.
35. Niu, Z., Li, A., Zhang, S. X., and Schwartz, R. J. (2007) Serum response factor micro-managing cardiogenesis. Curr Opin Cell Biol 19, 618–627.
36. Buskin, J. N., and Hauschka, S. D. (1989) Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. Mol Cell Biol 9, 2627–2640.
37. Blackwell, T. K., and Weintraub, H. (1990) Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science 250, 1104–1110.
38. Wright, W. E., Binder, M., and Funk, W. (1991) Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site. Mol Cell Biol 11, 4104–4110.
39. Merika, M., and Orkin, S. H. (1993) DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13, 3999–4010.
40. Karasseva, N., Tsika, G., Ji, J., Zhang, A., Mao, X., and Tsika, R. (2003) Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Mol Cell Biol 23, 5143–5164.
41. Huang, J., Blackwell, T. K., Kedes, L., and Weintraub, H. (1996) Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol 16, 3893–3900.
42. Weintraub, H., Davis, R., Lockshon, D., and Lassar, A. (1990) MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. Proc Natl Acad Sci U S A 87, 5623–5627.
43. Rosenblatt, J. D., Lunt, A. I., Parry, D. J., and Partridge, T. A. (1995) Culturing satellite cells from living single muscle fiber explants. In Vitro Cell Dev Biol Anim 31, 773–779.
44. Favre, D., Cherel, Y., Provost, N., Blouin, V., Ferry, N., Moullier, P., and Salvetti, A. (2000) Hyaluronidase enhances recombinant adeno-associated virus (rAAV)-mediated gene transfer in the rat skeletal muscle. Gene Ther 7, 1417–1420.
45. Wozniak, A. C., and Anderson, J. E. (2005) Single-fiber isolation and maintenance of satellite cell quiescence. Biochem Cell Biol 83, 674–676.
46. Lee, T. C., Chow, K. L., Fang, P., and Schwartz, R. J. (1991) Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells. Mol Cell Biol 11, 5090–5100.
47. Chen, C. Y., and Schwartz, R. J. (1996) Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol 16, 6372–6384.
48. Groisman, R., Masutani, H., Leibovitch, M. P., Robin, P., Soudant, I., Trouche, D., and Harel-Bellan, A. (1996) Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins. J Biol Chem 271, 5258–5264.
49. Gupta, M., Kogut, P., Davis, F. J., Belaguli, N. S., Schwartz, R. J., and Gupta, M. P. (2001) Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1. J Biol Chem 276, 10413–10422.
50. Natesan, S., and Gilman, M. (1995) YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol Cell Biol 15, 5975–5982.
51. Durocher, D., and Nemer, M. (1998) Combinatorial interactions regulating cardiac transcription. Dev Genet 22, 250–262.
52. Lee, Y., Shioi, T., Kasahara, H., Jobe, S. M., Wiese, R. J., Markham, B. E., and Izumo, S. (1998) The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol 18, 3120–3129.
53. Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C. Y., Nemer, M., and Schwartz, R. J. (1998) GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol 18, 3405–3415.
54. Morin, S., Charron, F., Robitaille, L., and Nemer, M. (2000) GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J 19, 2046–2055.
55. Iwahori, A., Fraidenraich, D., and Basilico, C. (2004) A conserved enhancer element that drives FGF4 gene expression in the embryonic myotomes is synergistically activated by GATA and bHLH proteins. Dev Biol 270, 525–537.
56. Dai, Y. S., Cserjesi, P., Markham, B. E., and Molkentin, J. D. (2002) The transcription factors GATA4 and dHAND physically inter- act to synergistically activate cardiac gene expression through a p300-dependent mechanism. J Biol Chem 277, 24390–24398.
57. Garg, V., Kathiriya, I. S., Barnes, R., Schluterman, M. K., King, I. N., Butler, C. A., Rothrock, C. R., Eapen, R. S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J. C., and Srivastava, D. (2003) GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424, 443–447.
58. Chen, Y., and Cao, X. (2009) NFAT directly regulates Nkx2-5 transcription during cardiac cell differentiation. Biol Cell 101, 335–349.
59. Bhalla, S. S., Robitaille, L., and Nemer, M. (2001) Cooperative activation by GATA-4 and YY1 of the cardiac B-type natriuretic peptide promoter. J Biol Chem 276, 11439–11445.
60. Stennard, F. A., Costa, M. W., Elliott, D. A., Rankin, S., Haast, S. J., Lai, D., McDonald, L. P., Niederreither, K., Dolle, P., Bruneau, B. G., Zorn, A. M., and Harvey, R. P. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 262, 206–224.
61. Molkentin, J. D., Black, B. L., Martin, J. F., and Olson, E. N. (1995) Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125–1136.
62. Morin, S., Pozzulo, G., Robitaille, L., Cross, J., and Nemer, M. (2005) MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem 280, 32272–32278.
63. Maeda, T., Gupta, M. P., and Stewart, A. F. (2002) TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters. Biochem Biophys Res Commun 294, 791–797.
64. Armand, A. S., Bourajjaj, M., Martinez-Martinez, S., el Azzouzi, H., da Costa Martins, P. A., Hatzis, P., Seidler, T., Redondo, J. M., and De Windt, L. J. (2008) Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem 283, 29004–29010.