CaMKII regulates pericyte loss in the retina of early diabetic mouse

Molecules and Cells

Volumn 31, Issue 3, 2011, Pages 289-293

  Kim, Young Hee ^a   Kim, Yoon Sook ^a   Park, So Yun ^a   Park, Chang Hwan ^a   Choi, Wan Sung ^a   Cho, Gyeong Jae ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

AIP; CaMKII; Diabetic retina; INOS; Pericyte death

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AUTOCAMTIDE 2 RELATED INHIBITORY PEPTIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASPASE 3; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOFLUORESCENCE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PERICYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; RETINA; WESTERN BLOTTING;

ANIMALS; BLOOD-RETINAL BARRIER; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CASPASE 3; CELL DEATH; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; ENZYME ASSAYS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; PERICYTES; RETINA; UP-REGULATION;

MUS;

EID: 79960028725     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-011-0038-2     Document Type: Article

References (28)

1. 2+ entry by CaMKII inhibitors in bovine vascular endothelial cells. Am. J. Physiol. Cell Physiol. 289, C1426-1436. (Pubitemid 41636347)
2. 2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery. Pharmacol. Res. 52, 252-257. (Pubitemid 40981926)
3. Carmo, A., Cunha-Vaz, J.G., Carvalho, A.P., and Lopes, M.C. (2000). Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability. Nitric Oxide 4, 590-596. (Pubitemid 32053270)
4. Cheung, A.K., Fung, M.K., Lo, A.C., Lam, T.T., So, K.F., Chung, S.S., and Chung, S.K. (2005). Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 54, 3119-3125. (Pubitemid 43334364)
5. Christopherson, K.S., and Bredt, D.S. (1997). Nitric oxide in excitable tissues: physiological roles and disease. J. Clin. Invest. 100, 2424-2429. (Pubitemid 27514880)
6. Cooper, N.G., Laabich, A., Fan, W., and Wang, X. (2008). The relationship between neurotrophic factors and CaMKII in the death and survival of retinal ganglion cells. Prog. Brain Res. 173, 521-540.
7. Cruzalegui, F.H., Kapiloff, M.S., Morfin, J.P., Kemp, B.E., Rosenfeld, M.G., and Means, A.R. (1992). Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 89, 12127-12131. (Pubitemid 23004798)
8. Ellis, E.A., Guberski, D.L., Hutson, B., and Grant, M.B. (2002). Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat. Nitric Oxide 6, 295-304. (Pubitemid 34852373)
9. Goebel, D.J. (2009). Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons. Brain Res. 1256, 190-204.
10. Jones, R.J., Jourd'heuil, D., Salerno, J.C., Smith, S.M., and Singer, H.A. (2007). iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Am. J. Physiol. Heart Circ. Physiol. 292, H2634-2642. (Pubitemid 47084512)
11. Joussen, A.M., Poulaki, V., Le, M.L., Koizumi, K., Esser, C., Janicki, H., Schraermeyer, U., Kociok, N., Fauser, S., Kirchhof, B., et al. (2004). A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 18, 1450-1452. (Pubitemid 39561611)
12. Kato, I., Oya, T., Suzuki, H., Takasawa, K., Ichsan, A.M., Nakada, S., Ishii, Y., Shimada, Y., Sasahara, M., Tobe, K., et al. (2008). A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells. Diabetes Metab. Res. Rev. 24, 486-497.
13. Kaur, C., Sivakumar, V., Foulds, W.S., Luu, C.D., and Ling, E.A. (2009). Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia. Invest. Ophthalmol. Vis. Sci. 50, 5364-5374.
14. Kim, Y.H., Kim, Y.S., Kang, S.S., Noh, H.S., Kim, H.J., Cho, G.J., and Choi, W.S. (2005). Expression of 14-3-3 zeta and interaction with protein kinase C in the rat retina in early diabetes. Diabetologia 48, 1411-1415. (Pubitemid 41186109)
15. Kim, Y.H., Choi, M.Y., Kim, Y.S., Han, J.M., Lee, J.H., Park, C.H., Kang, S.S., Choi, W.S., and Cho, G.J. (2007). Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes. Neurobiol. Dis. 28, 293-303. (Pubitemid 350123594)
16. Ko, S.H., Ryu, G.R., Kim, S., Ahn, Y.B., Yoon, K.H., Kaneto, H., Ha, H., Kim, Y.S., and Song, K. H. (2008). Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. Transplantation 85, 323-330. (Pubitemid 351322754)
17. Leal, E.C., Manivannan, A., Hosoya, K., Terasaki, T., Cunha-Vaz, J., Ambrosio, A.F., and Forrester, J.V. (2007). Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest. Oph-thalmol. Vis. Sci. 48, 5257-5265. (Pubitemid 351260939)
18. Lee, B.R., Lee, Y.P., Kim, D.W., Song, H.Y., Yoo, K.Y., Won, M.H., Kang, T.C., Lee, K.J., Kim, K.H., Joo, J.H., et al. (2010). Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide. Mol. Cells 29, 349-354.
19. Li, F., and Mahato, R.I. (2008). iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. Mol. Pharm. 5, 407-417. (Pubitemid 351929825)
20. Lipton, S.A., Choi, Y.B., Pan, Z.H., Lei, S.Z., Chen, H.S., Sucher, N.J., Loscalzo, J., Singel, D.J., and Stamler, J.S. (1993). A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626-632. (Pubitemid 23274719)
21. Munevar, S., Gangopadhyay, S.S., Gallant, C., Colombo, B., Sellke, F.W., and Morgan, K.G. (2008). CaMKIIT287 and T305 regulate history-dependent increases in alpha agonist-induced vascular tone. J. Cell Mol. Med. 12, 219-226. (Pubitemid 351430464)
22. Ozveren, E., Korkmaz, B., Buharalioglu, C.K., and Tunctan, B. (2006). Involvement of calcium/calmodulin-dependent protein kinase II to endotoxin-induced vascular hyporeactivity in rat superior mesenteric artery. Pharmacol. Res. 54, 208-218. (Pubitemid 44119201)
23. She, H., Nakazawa, T., Matsubara, A., Hisatomi, T., Young, T.A., Michaud, N., Connolly, E., Hafezi-Moghadam, A., Gragoudas, E.S., and Miller, J.W. (2007). Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 48, 2268-2277. (Pubitemid 351261305)
24. Soderling, T.R. (1996). Structure and regulation of calcium/calmodulin- dependent protein kinases II and IV. Biochim. Biophys. Acta 1297, 131-138. (Pubitemid 26358920)
25. Tang, J., Mohr, S., Du, Y.D., and Kern, T.S. (2003). Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans. Curr. Eye Res. 27, 7-13. (Pubitemid 36936342)
26. Yousif, M.H., Akhtar, S., Walther, T., and Benter, I.F. (2008). Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension. Cell Biochem. Funct. 26, 256-263. (Pubitemid 351373975)
27. Zhang, S., Yang, Y., Kone, B.C., Allen, J.C., and Kahn, A.M. (2003). Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmo-dulindependent protein kinase II. Circulation 107, 1539-1544. (Pubitemid 36378494)
28. Zheng, L., Du, Y., Miller, C., Gubitosi-Klug, R.A., Ball, S., Berkowitz, B.A., and Kern, T.S. (2007). Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia 50, 1987-1996. (Pubitemid 47222853)