Variation in KCNQ1 is associated with therapeutic response to sulphonylureas

Medical Science Monitor

Volumn 17, Issue 7, 2011, Pages

  Schroner, Zbynek ^a   Dobrikova, Martina ^a   Klimcakova, Lucia ^a   Javorsky, Martin ^a   Zidzik, Jozef ^a   Kozarova, Miriam ^a   Hudakova, Terezia ^a   Tkacova, Ruzena ^a   Salagovic, Jan ^a   Tkac, Ivan ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

Author keywords

Glycemic control; KCNQ1; Pharmacogenetics; Sulphonylureas; Type 2 diabetes

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; POTASSIUM CHANNEL KCNQ1; SULFONYLUREA; TRIACYLGLYCEROL;

ADD ON THERAPY; ADULT; AGED; ALLELE; ARTICLE; BODY MASS; BODY WEIGHT; DRUG RESPONSE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; REAL TIME POLYMERASE CHAIN REACTION;

EID: 79960022589     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881850     Document Type: Article

References (22)

1. McCarthy MI: Genomics, type 2 diabetes, and obesity. N Engl J Med, 2010; 363: 2339-2350
2. Unoki H, Takahashi A, Kawaguchi T et al: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet, 2008; 40: 1098-1102
3. Yasuda K, Miyake E, Horikawa Y et al: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet, 2008; 40: 1092-1097
4. Qi Q, Li H, Loos RJF et al: Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet, 2009; 18: 3508-3515
5. Zhou JB, Yang JK, Zhao L, Xin Z: Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: A case-control study and meta-analysis. Med Sci Monit, 2010; 16(6): BR179-BR183
6. Hu C, Wang C, Zhang R et al: Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in Chinese population. Diabetologia, 2009; 52: 1322-1325
7. Jonsson A, Isomaa B, Tuomi T et al: A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes, 2009; 58: 2409-2413
8. Barhanin J, Lesage F, Guillemare E et al: K(V)LQT1 and IsK (mink) proteins associate to form the I(Ks) cardiac potassium current. Nature, 1996; 38: 78-80
9. Demolombe S, Franco D, de Boer P et al: Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol, 2001; 280: C359-C372
10. Wang Q, Curran ME, Splawski I et al: Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhytmias. Nat Genet, 1996; 12: 17-23
11. Chen YH, Xu SJ, Benahhou S et al: KCNQ1 gain-of-function mutation in familial atrial fbrillation. Science, 2003; 299: 251-254
12. Ullrich S, Su J, Wittekindt OH et al: Effects of I (Ks) channel inhibitors in insulin-secreting INS-1 cells. Pfugers Arch, 2005; 451: 428-436
13. Tan JT, Nurbaya S, Gardner D et al: Genetic variation in KCNQ1 associates with fasting glucose and b-cell function. A study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes, 2009; 58: 1445-1449
14. Holmkvist J, Banasik K, Andersen G et al: The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. PLoS ONE, 2009; 4: e5872
15. Müssig K, Staiger H, Machicao F et al: Association of type 2 diabetes candidate polymorphism in KCNQ1 with incretin and insulin secretion. Diabetes, 2009; 57: 1715-1720
16. Nathan DM, Buse JB, Davidson MB et al: Management of hyperglycae-mia in type 2 diabetes: a consensus algorithm for initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia, 2006; 49: 1711-1721
17. Gribble FM, Reimann F: Sulphonylurea action revisited: the post cloning era. Diabetologia, 2003; 46: 875-891
18. Zhang H, Liu X, Kuang H et al: Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes. Diabetes Res Clin Pract, 2007; 77: 58-61
19. Feng Y, Mao G, Ren X et al: Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic effcacy of gliclazide in Chinese type 2 diabetic patients. Diabetes Care, 2008; 31: 1939-1944
20. Pearson ER, Donelly LA, Kimber C et al: Variation in TCF7L2 infuenc-es therapeutic response to sulfonylureas. A GoDARTs Study. Diabetes, 2007; 56: 2178-2182
21. Schroner Z, Javorsky M, Tkacova R et al: Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes. Diabetes Obes Metab, 2011; 13: 89-91
22. American Diabetes Association: Diagnosis and classifcation of diabetes mellitus. Diabetes Care, 2006; 29(Suppl.1): S43-S48