The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder

Genes, Brain and Behavior

Volumn 10, Issue 5, 2011, Pages 523-529

  Da Rocha, F F ^a   Malloy Diniz, L ^b   Lage, N V ^a   Correa H ^a,b  

^a Medicine Molecular Program   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

BDNF; Decision making; Executive function; Frontosubcortical circuit; Iowa gambling task; Obsessive compulsive disorder; Orbitofrontal cortex

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SCATTER FACTOR RECEPTOR;

ADULT; AGED; ALLELE; AMBIGUITY; ARTICLE; BECK ANXIETY INVENTORY; CAUCASIAN; CLINICAL ARTICLE; DECISION MAKING; FEMALE; GENETIC POLYMORPHISM; HUMAN; MALE; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOLOGIC TEST; TASK PERFORMANCE;

ADOLESCENT; ADULT; AGED; ALLELES; BRAIN-DERIVED NEUROTROPHIC FACTOR; DECISION MAKING; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES;

EID: 79960016336     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2011.00687.x     Document Type: Article

References (47)

1. Bath, K.G. & Lee, F.S. (2006) Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Neurosci 6, 79-85.
2. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J. & Erbaugh, J. (1961) An inventory for measuring depression. Arch Gen Psychiatry 4, 561-571.
3. Beck, A.T., Epstein, N., Brown, G. & Steer, R.A. (1988) An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 56, 893-897.
4. van den Bos, R., Homberg, J., Gijsbers, E., den Heijer, E. & Cuppen, E. (2009) The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology 56, 493-498.
5. Britton, J.C., Stewart, S.E., Killgore, W.D., Rosso, I.M., Price, L.M., Gold, A.L., Pine, D.S., Wilhelm, S., Jenike, M.A. & Rauch, S.L. (2010) Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. Depress Anxiety 27, 643-651.
6. Cannistraro, P.A., Wright, C.I., Wedig, M.M., Martis, B., Shin, L.M., Wilhelm, S. & Rauch, S.L. (2004) Amygdala responses to human faces in obsessive-compulsive disorder. Biol Psychiatry 56, 916-920.
7. Cavallaro, R., Cavedini, P., Mistretta, P., Bassi, T., Angelone, S.M. & Ubbiali, A. (2003) Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: a controlled, double dissociation study. Biol Psychiatry 54, 437-443.
8. Chamberlain, S.R., Menzies, L., Hampshire, A., Suckling, J., Fineberg, N.A. & del Campo, N. (2008) Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321, 421-422.
9. Chan, R.C., Shum, D., Toulopoulou, T. & Chen, E.Y. (2008) Assessment of executive functions: review of instruments and identification of critical issues. Arch Clin Neuropsychol 23, 201-216.
10. Deltheil, T., Guiard, B.P., Guilloux, J.P., Nicolas, L., Delomenie, C. & Reperant, C. (2008) Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacol Biochem Behav 90, 174-183.
11. Gasic, G.P., Smoller, J.W., Perlis, R.H., Sun, M., Lee, S. & Kim, B.W. (2009) BDNF, relative preference, and reward circuitry responses to emotional communication. Am J Med Genet B Neuropsychiatr Genet 150B, 762-781.
12. Geurts, H.M., van der Oord, S. & Crone, E.A. (2006) Hot and cool aspects of cognitive control in children with ADHD: decision-making and inhibition. J Abnorm Child Psychol 34, 813-824.
13. Goodman, W.K., Price, L.H., Rasmussen, S.A., Mazure, C., Fleischmann, R.L. & Hill, C.L. (1989a) The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Part I: reliability. Arch Gen Psychiatry 46, 1006-1011.
14. Goodman, W.K., Price, L.H., Rasmussen, S.A., Mazure, C., Delgado, P. & Heninger, G.R. (1989b) The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Part II: validity. Arch Gen Psychiatry 46, 1012-1016.
15. Grisham, J.R., Norberg, M.M., Williams, A.D., Certoma, S.P. & Kadib, R. (2010) Categorization and cognitive deficits in compulsive hoarding. Behav Res Ther 48, 866-872.
16. Ha, R.Y., Namkoong, K., Kang, J.I., Kim, Y.T. & Kim, S.J. (2009) Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making. Prog Neuropsychopharmacol Biol Psychiatry 33, 1217-1222.
17. Harrison, B.J., Soriano-Mas, C., Pujol, J., Ortiz, H., López-Solà, M. & Hernández-Ribas, R. (2009) Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch Gen Psychiatry 66, 1189-1200.
18. Ho, B.C., Milev, P., O'Leary, D.S., Librant, A., Andreasen, N.C. & Wassink, T.H. (2006) Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry 63, 731-740.
19. Kang, J.I., Namkoong, K., Ha, R.Y., Jhung, K., Kim, Y.T. & Kim, S.J. (2010) Influence of BDNF and COMT polymorphisms on emotional decision making. Neuropharmacology 58, 1109-1113.
20. Kwon, J.S., Jang, J.H., Choi, J.S. & Kang, D.H. (2009) Neuroimaging in obsessive-compulsive disorder. Expert Rev Neurother 9, 255-269.
21. Li, X., Lu, Z.L., D'Argembeau, A., Ng, M. & Bechara, A. (2010) The Iowa Gambling Task in fMRI images. Hum Brain Mapp 31, 410-423.
22. Liao, P.C., Uher, R., Lawrence, N., Treasure, J., Schmidt, U., Campbell, I.C., Collier, D.A. & Tchanturia, K. (2009) An examination of decision making in bulimia nervosa. J Clin Exp Neuropsychol 31, 455-461.
23. Malloy-Diniz, L., Fuentes, D., Leite, W.B., Correa, H. & Bechara, A. (2007) Impulsive behavior in adults with attention deficit/hyperac- tivity disorder: characterization of attentional, motor and cognitive impulsiveness. J Int Neuropsychol Soc 13, 693-698.
24. Malloy-Diniz, L.F., Leite, W.B., de Moraes, P.H., Correa, H., Bechara, A. & Fuentes, D. (2008) Brazilian Portuguese version of the Iowa Gambling Task: transcultural adaptation and discriminant validity. Rev Bras Psiquiatr 30, 144-148.
25. Malloy-Diniz, L.F., Neves, F. & Corrêa, H. (2009) Neuropsychological aspects of bipolar disorder. Rev Bras Psiquiatr 31, 183-185.
26. Menzies, L., Chamberlain, S.R., Laird, A.R., Thelen, S.M., Sahakian, B.J. & Bullmore, E.T. (2008) Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32, 525-549.
27. Nielen, M.M., Veltman, D.J., de Jong, R., Mulder, G. & den Boer, J.A. (2002) Decision making performance in obsessive compulsive disorder. J Affect Disord 69, 257-260.
28. Olley, A., Malhi, G. & Sachdev, P. (2007) Memory and executive functioning in obsessive compulsive disorder: a selective review. J Affect Disord 104, 15-23.
29. Parra, F.C., Amado, R.C., Lambertucci, J.R., Rocha, J., Antunes, C.M. & Pena, S.D. (2003) Color and genomic ancestry in Brazilians. Proc Natl Acad Sci U S A 100, 177-182.
30. Petryshen, T.L., Sabeti, P.C., Aldinger, K.A., Fry, B., Fan, J.B., Schaffner, S.F., Waggoner, S.G., Tahl, A.R. & Sklar, P. (2010) Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry 15, 810-815.
31. Raven, J.C. (1948) The comparative assessment of intellectual ability. Br J Psychol 39, 12-19.
32. Reitan, R.M. & Wolfson, D. (1985) The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Neuropsychology Press, Tucson, AZ.
33. Da Rocha, F.F., Malloy-Diniz, L., de Sousa, K.C., Prais, H.A., Correa, H. & Teixeira, A.L. (2008a) Borderline personality features possibly related to cingulate and orbitofrontal cortices dysfunction due to schizencephaly. Clin Neurol Neurosurg 110, 396-399.
34. Da Rocha, F.F., Malloy-Diniz, L., Lage, N.V., Romano-Silva, M.A., de Marco, L.A. & Correa, H. (2008b) Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder. Behav Brain Res 195, 159-163.
35. Da Rocha, F.F., Malloy-Diniz, L., Lage, N.V. & Correa, H. (2010) Positive association between MET allele (BDNF Val66Met polymorphism) and obsessive-compulsive disorder. Rev Bras Psiquiatr 32, 323-324.
36. Da Rocha, F.F., Alvarenga, N.B., Lage, N.V., Romano-Silva, M.A., de Marco, L.A. & Corrêa, H. (in press) Associations between polymorphic variants of the tryptophan hydroxylase 2 gene and obsessive-compulsive disorder. Rev Bras Psiquiatr (in press).
37. Rogers, R.D. (2011) The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacology 36, 114-132.
38. Rosario-Campos, M.C., Miguel, E.C., Quatrano, S., Chacon, P., Ferrao, Y. & Findley, D. (2006) The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry 11, 495-504.
39. Roth, T.L. & Sweatt, J.D. (in press) Epigenetic marking of the BDNF gene by early-life adverse experiences. Horm Behav (in press).
40. Rybakowski, J.K. (2008) BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics 9, 1589-1593.
41. Schlösser, R.G., Wagner, G., Schachtzabel, C., Peikert, G., Koch, K., Reichenbach, J.R. & Sauer, H. (2010) Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp 31, 1834-1850.
42. Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J. & Weiller, E. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59, 22-33.
43. Starcke, K., Tuschen-Caffier, B., Markowitsch, H.J. & Brand, M. (2009) Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry 14, 199-216.
44. Starcke, K., Tuschen-Caffier, B., Markowitsch, H.J. & Brand, M. (2010) Dissociation of decisions in ambiguous and risky situations in obsessive-compulsive disorder. Psychiatry Res 175, 114-120.
45. Stoltenberg, S.F. & Vandever, J.M. (2010) Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology 58, 423-428.
46. Tramontina, J.F., Yates, D., Magalhães, P.V., Trentini, C., Sant'anna, M.K. & Fries, G.R. (2009) Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder. Rev Bras Psiquiatr 31, 36-40.
47. Yamada, K., Mizuno, M. & Nabeshima, T. (2002) Role for brain-derived neurotrophic factor in learning and memory. Life Sci 70, 735-744.