Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder

Behavioural Brain Research

Volumn 195, Issue 1, 2008, Pages 159-163

  da Rocha, Felipe Filardi ^a   Malloy Diniz, Leandro ^a   Lage, Naira Vassalo ^a   Romano Silva, Marco Aurélio ^a   de Marco, Luiz Armando ^a   Correa, Humberto ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

5 HTTLPR; Decision making; Executive function; Fronto subcortical circuit; Iowa gambling task; Obsessive compulsive disorder; Orbitofrontal cortex

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; CAUCASIAN; CLINICAL ARTICLE; DECISION MAKING; FEMALE; GENETIC POLYMORPHISM; HUMAN; MALE; NEUROPSYCHOLOGY; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; PROMOTER REGION; PSYCHOLOGIC TEST; RATING SCALE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; DECISION MAKING; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GAMBLING; GENOTYPE; HUMANS; INTELLIGENCE TESTS; MALE; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PSYCHOMOTOR PERFORMANCE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 52949118472     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.05.015     Document Type: Article

References (29)

1. Aouizerate B., Guehl D., Cuny E., Rougier A., Bioulac B., Tignol J., et al. Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol 72 3 (2004) 195-221
2. Bannon S., Gonsalvez C.J., Croft R.J., and Boyce P.M. Executive functions in obsessive-compulsive disorder: state or trait deficits?. Aust N Z J Psychiatry 40 (2006) 1031-1038
3. Bechara A. Neurobiology of decision-making: risk and reward. Semin Clin Neuropsychiatry 6 3 (2001) 205-216
4. Bechara A., Damasio H., Damasio A.R., and Lee G.P. Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19 (1999) 5473-5481
5. Beck A.T., Epstein N., Brown G., and Steer R.A. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 56 6 (1988) 893-897
6. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
7. Bloch M.H., Landeros-Weisenberger A., Sen S., Dombrowski P., Kelmendi B., Coric V., et al. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet (2009) [Epub ahead of print]
8. Cavedini P., Gorini A., and Bellodi L. Understanding obsessive-compulsive disorder: focus on decision making. Neuropsychol Rev 16 1 (2006) 3-15
9. Canli T., and Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 10 9 (2007) 1103-1109
10. Chamberlain S.R., Blackwell A.D., Fineberg N.A., Robbins T.W., and Sahakian B.J. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Ver 29 3 (2005) 399-419
11. Correa H., De Marco L., Boson W., Viana M.M., Lima V.F., Campi-Azevedo A.C., et al. Analysis of T102C 5-HT2A polymorphism in Brazilian psychiatric inpatients: association with suicidal behavior. Cell Mol Neurobiol 22 (2002) 813-817
12. Fenger M.M., Gade A., Adams K.H., Hansen E.S., Bolwig T.G., and Knudsen G.M. Cognitive deficits in obsessive-compulsive disorder on tests of frontal lobe functions. Nord J Psychiatry 59 1 (2005) 39-44
13. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Part I: reliability. Arch Gen Psychiatry 46 (1989) 1006-1011
14. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Part II: validity. Arch Gen Psychiatry 46 (1989) 1012-1016
15. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78 (2006) 815-826
16. Jollant F., Buresi C., Guillaume S., Jaussent I., Bellivier F., Leboyer M., et al. The influence of four serotonin-related genes on decision-making in suicide attempters. Am J Med Genet B Neuropsychiatr Genet 144 5 (2007) 615-624
17. Lawrence N.S., Wooderson S., Mataix-Cols D., David R., Speckens A., and Phillips M.L. Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder. Neuropsychology 20 4 (2006) 409-419
18. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
19. Lin P.Y. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 31 3 (2007) 683-689
20. Malloy-Diniz L., Fuentes D., Leite W.B., Correa H., and Bechara A. Impulsive behavior in adults with attention deficit/hyperactivity disorder: characterization of attentional, motor and cognitive impulsiveness. J Int Neuropsychol Soc 13 4 (2007) 693-698
21. Menzies L., Achard S., Chamberlain S.R., Fineberg N., Chen C.H., del Campo N., et al. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 130 Pt 12 (2007) 3223-3236
22. Parra F.C., Amado R.C., Lambertucci J.R., Rocha J., Antunes C.M., and Pena S.D. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA 100 (2003) 177-182
23. Raven J.C. The comparative assessment of intellectual ability. Br J Psychol 39 (1948) 12-19
24. Reitan R.M., and Wolfson D. The Halstead-Reitan neuropsycyhological test battery: theory and clinical interpretation (1985), Neuropsychology Press, Tucson, AZ
25. Rocha F.F., Sousa K.C.A., Teixeira A.L., Fontenelle L.F., Romano-Silva M.A., and Correa H. Studies of association between the obsessive compulsive disorder and candidate genes: a review. J Bras Psiquiatr 55 (2006) 288-295
26. Rosario-Campos M.C., Miguel E.C., Quatrano S., Chacon P., Ferrao Y., Findley D., et al. The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry 11 5 (2006) 495-504
27. Sachdev P.S., and Malhi G.S. Obsessive-compulsive behaviour: a disorder of decision-making. Aust N Z J Psychiatry 39 9 (2005) 757-763
28. Strobel A., Dreisbach G., Müller J., Goschke T., Brocke B., and Lesch K.P. Genetic variation of serotonin function and cognitive control. J Cogn Neurosci 19 12 (2007) 1923-1931
29. Yucel M., Harrison B.J., Wood S.J., Fornito A., Wellard R.M., Pujol J., et al. Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry 64 8 (2007) 946-955