Single cells can sense their position in a morphogen gradient

Development

Volumn 126, Issue 23, 1999, Pages 5309-5317

  Gurdon, J B ^a   Standley, H ^a   Dyson, S ^a   Butler, K ^a   Langon, T ^a   Ryan, K ^a   Stennard, F ^a   Shimizu, K ^a   Zorn, A ^a  

^a NONE

Author keywords

Activin; Eomesodermin; Morphogen gradient; Xbrachyury; Xenopus

Indexed keywords

ACTIVIN; AGAROSE; FIBRONECTIN; MORPHOGEN;

ANIMAL CELL; ARTICLE; BLASTULA; CELL ACTIVITY; CELL AGGREGATION; CELL CLONE; CELL COMMUNICATION; CELL CONTACT; CELL CULTURE; CELL INTERACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; RIBONUCLEASE PROTECTION ASSAY; XENOPUS;

ACTIVINS; ANIMALS; BLASTOMERES; CELL COMMUNICATION; CELL LINEAGE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION; GLYCOPROTEINS; GOOSECOID PROTEIN; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; INHIBINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEINS; RECEPTORS, FIBROBLAST GROWTH FACTOR; REPRESSOR PROTEINS; RIBONUCLEASES; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; XENOPUS; XENOPUS PROTEINS;

ANIMALIA; CERBERUS; VERTEBRATA;

EID: 0033390936     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Asashima, M., Nakano, H., Uchiyama, H., Sugino, H., Nakamura, T., Eto, Y., Ejima, D., Nishimatsu, S., Ueno, N. and Kinoshita, K. (1991). Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. Proc. Natl. Acad. Sci. USA 88, 6511-6514.
2. Bouwmeester, T., Kim, S.-Y., Sasai, Y., Lu, B. and De Robertis, E. M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
3. Butler, K., Zorn, A. and Gurdon, J. B. (1999). Non-radioactive on situ hybridization to Xenopus tissue sections. Methods: in situ hybridization in developmental biology. Academic Press (in press).
4. Carnac, G. and Gurdon, J. B. (1997). The community effect in Xenopus myogenesis is promoted by dorsalizing factors. Int. J. Dev. Biol. 41, 521-524.
5. Cho, K. H. Y., Blumberg, B., Steinbeisser, H. and De Robertis, E. M. (1991). Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120.
6. Dyson, S. and Gurdon, J. B. (1998). The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93, 557-568.
7. Godsave, S. F. and Slack, J. M. W. (1991). Single cell analysis of mesoderm formation in the Xenopus embryo. Development 111, 523-530.
8. Green, J. B. and Smith, J. C. (1990). Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347, 391-394.
9. Green, J. B., New, H. V. and Smith, J. C. (1992). Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71, 731-739.
10. Green, J. B., Smith, J. C. and Gerhart, J. C. (1994). Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern. Development 120, 2271-2278.
11. Gurdon, J. B. (1977). Methods for nuclear transplantation in Amphibia. In Methods in Cell Biology 16 (ed. G. Stein, J. Stein and L. J. Kleinsmith), pp. 125-139. New York: Academic Press.
12. Gurdon, J. B., Tiller, E., Roberts, J. and Kato, K. (1993). A community effect in muscle development. Curr. Biol. 3, 1-11.
13. Gurdon, J. B., Harger, P., Mitchell, A. and Lemaire, P. (1994). Activin signalling and response to a morphogen gradient. Nature 371, 487-492.
14. Gurdon, J. B., Dyson, S. and St Johnson, D. (1998). Cells' perception of position in a concentration gradient. Cell 95, 159-162.
15. Harland, R. M. (1991). In situ hybridisation: an improved whole-mount method for Xenopus embryos. Meth. Cell Biol. 36, 685-695.
16. Horb, M. E. and Thomsen, G. H. (1997). A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation. Development 124, 1689-1698.
17. Howard, J. E. and Smith, J. C. (1993). Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis. Mech. Dev. 43, 37-48.
18. Hudson, C., Clements, D., Friday, R. V., Stott, D. and Woodland, H. R. (1997). Xsox17alpha and -beta mediate endoderm formation in Xenopus. Cell 91, 397-405.
19. Lemaire, P. and Gurdon, J. B. (1994). A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos. Development 120, 1191-1199.
20. Lustig, K. D., Kroll, K. L., Sun, E. E. and Kirschner, M. W. (1996). Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development 122, 4001-4012.
21. McDowell, N., Zorn, A. M., Crease, D. J. and Gurdon, J. B. (1997). Activin has a direct longe range signalling activity and can form a concentration gradient by diffusion. Curr. Biol. 7, 671-681.
22. Newman, C. S., Chia, F. and Krieg, P. A. (1997). The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev. 66, 83-93.
23. Ramos, J. W., Whittaker, C. A. and DeSimone, D. W. (1996). Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation. Development 122, 2873-2883.
24. Rosa, F. M. (1989). Mix, I, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endoderm cells of Xenopus embryos. Cell 57, 965-974.
25. Ryan, K., Garrett, N., Mitchell, A. and Gurdon, J. B. (1996). Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell 87, 989-1000.
26. Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L. K. and De Robertis, E. M. (1994). Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79, 779-790.
27. Singer, M. A., Penton, A., Twombly, V., Hoffmann, F. M. and Gelbart, W. M. (1997). Signaling through both type 1 DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing. Development 124, 79-89.
28. Smith, J. C., Symes, K., Hynes, R. O. and DeSimone, D. (1990a). Mesoderm induction and control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins. Development 108, 229-238.
29. Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D. and Herrmann, B. G. (1991). Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79-87.
30. Smith, J. C. (1993). Mesoderm-inducing factors in early vertebrate development. EMBO J. 12, 4463-4470.
31. Stennard, F., Carnae, G. and Gurdon, J. B. (1996). The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation. Development 122, 4179-4188.
32. Stennard, F., Ryan, K. and Gurdon, J. B. (1997). Markers of vertebrate mesoderm induction. Curr. Opin. Genet. Dev. 7, 620-627.
33. Stennard, F., Zorn, A. M., Ryan, K., Garrett, N. and Gurdon, J. B. (1999). Differential expression of VegT and Antipodean protein isoforms in Xenopus. Mech. Dev. (in press).
34. Symes, K., Yaqoob, M. and Smith, J. C. (1988). Mesoderm induction in Xenopus laevis: responding cells must be in contact for mesoderm formation but suppression of epidermal differentiation can occur in single cells. Development 104, 609-618.
35. Symes, K., Yordan, C. and Mercola, M. (1994). Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin. Development 120, 2339-2346.
36. Taira, M., Jamrich, M., Good, P. J. and Dawid, I. B. (1992) The LIM domain-containing homeobox gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Genes Dev. 6, 356-366.
37. Thomsen, G., Woolf, T., Whitman, M., Sokol, S., Vaughan, J., Vale, W. and Melton, D. A. (1990). Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63, 485-493.
38. Wacker, S., Brodbeck, A., Lemaire, P., Niehrs, C. and Winklbauer, R. (1998). Patterns and control of cell motility in the Xenopus gastrula. Development 125, 1931-1942.
39. Watabe, T., Kim, S., Candia, A., Rothbacher, U., Hashimoto, C., Inoue, K. and Cho, K.W.Y. (1995). Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9, 3038-3050.
40. Wilson, P. A. and Melton, D. A. (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Curr. Biol. 4, 676-686.
41. Wolpert, L. (1969). Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol. 25, 1-47.
42. Zhang, J. and King, M. L. (1996). Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. Development 122, 4119-4129.