Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19

Molecular Vision

Volumn 17, Issue , 2011, Pages 1652-1661

  Ramirez Miranda, Arturo ^a   Nakatsu, Martin N ^a   Zarei Ghanavati, Siamak ^a   Nguyen, Christine V ^b   Deng, Sophie X ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKERATIN 12; CYTOKERATIN 13; CYTOKERATIN 19; RNA;

ADOLESCENT; ADULT; ANATOMICAL VARIATION; ARTICLE; CHILD; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CORNEA; CORNEA LIMBUS; EPITHELIUM CELL; GENE; GENE EXPRESSION PROFILING; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; K13 GENE; K19 GENE; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD;

ADULT; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; CONJUNCTIVA; CORNEA; EPITHELIAL CELLS; EPITHELIUM; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-12; KERATIN-13; KERATIN-19; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER;

EID: 79959996506     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Davanger M, Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 1971; 229:560-561. [PMID: 4925352]
2. Schermer A, Galvin S, Sun TT. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol 1986; 103:49-62. [PMID: 2424919]
3. Tseng SC. Concept and application of limbal stem cells. Eye (Lond) 1989; 3:141-57. [PMID: 2695347]
4. Shapiro MS, Friend J, Thoft RA. Corneal re-epithelialization from the conjunctiva. Invest Ophthalmol Vis Sci 1981; 21:135-142. [PMID: 7251297]
5. Puangsricharern V, Tseng SC. Cytologic evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology 1995; 102:1476-1485. [PMID: 9097795]
6. Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol 1977; 84:798-801. [PMID: 596392]
7. Krenzer KL, Freddo TF. Patterns of cytokeratin expression in impression cytology specimens from normal human conjunctival epithelium. Adv Exp Med Biol 1994; 350:289-292. [PMID: 7518181]
8. Chen WY, Mui MM, Kao WW, Liu CY, Tseng SC. Conjunctival epithelial cells do not transdifferentiate in organotypic cultures: expression of K12 keratin is restricted to corneal epithelium. Curr Eye Res 1994; 13:765-778. [PMID: 7531131]
9. Donisi PM, Rama P, Fasolo A, Ponzin D. Analysis of limbal stem cell deficiency by corneal impression cytology. Cornea 2003; 22:533-538. [PMID: 12883346]
10. Yoshida S, Shimmura S, Kawakita T, Miyashita H, Den S, Shimazaki J, Tsubota K. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci 2006; 47:4780-4786. [PMID: 17065488]
11. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells 2004; 22:355-366. [PMID: 15153612]
12. Kasper M, Moll R, Stosiek P, Karsten U. Patterns of cytokeratin and vimentin expression in the human eye. Histochemistry 1988; 89:369-377. [PMID: 2457569]
13. Barbaro V, Ferrari S, Fasolo A, Pedrotti E, Marchini G, Sbabo A, Nettis N, Ponzin D, Di Iorio E. Evaluation of ocular surface disorders: a new diagnostic tool based on impression cytology and confocal laser scanning microscopy. Br J Ophthalmol 2010; 94:926-932. [PMID: 19740872]
14. Ding Z, Dong J, Liu J, Deng SX. Preferential gene expression in the limbus of the vervet monkey. Mol Vis 2008; 14:2031-2041. [PMID: 18989386]
15. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini A. J, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5:R80. [PMID: 15461798]
16. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4:249-264. [PMID: 12925520]
17. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57. [PMID: 19131956]
18. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci 1996; 37:1684-1692. [PMID: 8675412]
19. Turner HC, Budak MT, Akinci MA, Wolosin JM. Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays. Invest Ophthalmol Vis Sci 2007; 48:2050-2061. [PMID: 17460260]
20. Elder MJ, Hiscott P, Dart JK. Intermediate filament expression by normal and diseased human corneal epithelium. Hum Pathol 1997; 28:1348-1354. [PMID: 9416689]
21. Waseem A, Alam Y, Dogan B, White KN, Leigh IM, Waseem NH. Isolation, sequence and expression of the gene encoding human keratin 13. Gene 1998; 215:269-279. [PMID: 9714826]
22. Kallioinen M, Koivukangas V, Jarvinen M, Oikarinen A. Expression of cytokeratins in regenerating human epidermis. Br J Dermatol 1995; 133:830-835. [PMID: 8547031]
23. Dota A, Nishida K, Adachi W, Nakamura T, Koizumi N, Kawamoto S, Okubo K, Kinoshita S. An expression profile of active genes in human conjunctival epithelium. Exp Eye Res 2001; 72:235-2341. [PMID: 11180972]
24. Jaworski CJ, Aryankalayil-John M, Campos MM, Fariss RN, Rowsey J, Agarwalla N, Reid T. W, Dushku N, Cox CA, Carper D, Wistow G. Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. Mol Vis 2009; 15:2421-2434. [PMID: 19956562]
25. Rosellini A, Papini S, Giannarini C, Nardi M, Revoltella RP. Human conjunctival epithelial precursor cells and their progeny in 3D organotypic culture. Int J Dev Biol 2007; 51:739-743. [PMID: 17939121]
26. Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K. S100 proteins in the epidermis. J Invest Dermatol 2004; 123:23-33. [PMID: 15191538]
27. Thorey IS, Roth J, Regenbogen J, Halle JP, Bittner M, Vogl T, Kaesler S, Bugnon P, Reitmaier B, Durka S, Graf A, Wockner M, Rieger N, Konstantinow A, Wolf E, Goppelt A, Werner S. The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J Biol Chem 2001; 276:35818-35825. [PMID: 11463791]
28. Riau AK, Wong TT, Beuerman RW, Tong L. Calcium-binding S100 protein expression in pterygium. Mol Vis 2009; 15:335-342. [PMID: 19223989]
29. Goebeler M, Roth J, van den Bos C, Ader G, Sorg C. Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filaments. Biochem J 1995; 309:419-424. [PMID: 7542868]
30. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 1989; 57:327-334. [PMID: 2702691]
31. Gipson IK, Spurr-Michaud S, Argueso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci 2003; 44:2496-2506. [PMID: 12766048]