Effect of ethanol leaf extract of Newboulda laevis on blood glucose levels of diabetic rats

Tropical Journal of Pharmaceutical Research

Volumn 10, Issue 3, 2011, Pages 249-254

  Owolabi, Omonkhelin J ^a   Amaechina, Fabian C ^a   Okoro, Mercy ^a  

^a UNIVERSITY OF BENIN   (Nigeria)

Author keywords

Antidiabetic; Blood glucose; Diabetes mellitus; Hypoglycemia; Newbouldia laevis

Indexed keywords

ALCOHOL; ALKALOID; ANTIDIABETIC AGENT; FLAVONOID; GLIBENCLAMIDE; GLUCOSE; NEWBOULDA LAEVIS EXTRACT; PLANT EXTRACT; SAPONIN; TANNIN; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BIGNONIACEAE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFECT; DRUG SAFETY; DRUG SCREENING; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LD 50; MALE; MOUSE; NEWBOULDA LAEVIS; NIGERIA; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; TRADITIONAL MEDICINE;

EID: 79959984153     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v10i3.12     Document Type: Article

References (17)

1. World Health Organization Resolution. Promotion and research development of training in traditional medicine. Technical Report, 1978, no. 622, Geneva.
2. Gbile ZO, Adesina SK. Nigerian flora and its pharmaceutical potentials. J. Ethnopharmacol 1986; 19:1-16.
3. Watt JM, Brayer-Brandwyk MG. The medicinal and poisonous plants of Southern and Eastern Africa. Livingstone: Edinburgh. 1962; p 3.
4. Kameswara RB, Kesavulu MM, Giri CH. Antidiabetic and hypolipidemic effects of Momordica cymbalania Hook fruit powder in alloxan-induced diabetic rats. J. Ethnopharmacol, 1999; 67: 103-109
5. Hutchinson J, Dalziel JM. Floral of West Tropical Africa, 1963: Vol 2, 5p
6. Arbonnier M. Trees, shrubs and lianas of West African, Dry zone. CIRAD. Margra GMBH MNHN. Cote D'ivoire. 2004; p 194
7. Usman H, Osuji JC. Phytochemical and in vitro antibacterial assay of the leaf extract of Newboulda laevis. Afr J. Trad CAM 2007; 4: 476-480
8. National Institute of Health, USA. Public health service policy on humane care and use of laboratory animals; 2002.
9. Evans WC. Trease and Evans Pharmacogonosy. 15th edn, Churchill Livingstone London, 2002; p 26.
10. Harbone JB. In Comparative biochemistry of flavonoids. Proc Natl Acad Sci 1993; 90: 4689-4692
11. Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol 1998; 54: 275-287.
12. Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diab Med 2005; 22: 359-370.
13. Rheney CC, Kirk JK. Performance of three blood glucose meters. Ann Pharmacother 2000; 34: 317-321.
14. Szudelski T. The mechanism of alloxan and streptozotocin action in β cells of the rat pancreas. Physiol Res 2001; 50: 536-546.
15. Katzung BG, Trevor A, Masters SB. Basic and Clinical Pharmacology. Mc-Graw Hill; 2009; p 346.
16. Frode TS, Medeiros A. Animal models to test drugs with potential antidiabetic activity. J. Ethnopharmacol 2008; 115: 173-183.
17. Schimizu M, Ito T, Rshima S, Mayashi T, Arisawa M, Morita-Kurokowa S, Ito Hasimato Y. Inhibition of lens aldose reductase by flavonoids. Phytochemistry 1984; 23: 1885-1888.