Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata

Phytochemistry

Volumn 72, Issue 11-12, 2011, Pages 1414-1423

  Foubert, Kenn ^a   Cuyckens, Filip ^b   Matheeussen, Ann ^a   Vlietinck, Arnold ^a   Apers, Sandra ^a   Maes, Louis ^a   Pieters, Luc ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antiangiogenic activity; Antiprotozoal activity; Apodytes dimidiata; Haemolytic activity; Icacinaceae; Saponins

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFECTIVE AGENT; ANTIPROTOZOAL AGENT; APODYTINE; HEMOLYTIC AGENT; SAPONIN;

ABDOMINAL AORTA; ANGIOSPERM; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; FRACTIONATION; HUMAN; IN VITRO STUDY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; RAT; SPRAGUE DAWLEY RAT;

ANGIOGENESIS INHIBITORS; ANGIOSPERMS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIPROTOZOAL AGENTS; AORTA, ABDOMINAL; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOLYTIC AGENTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

APODYTES DIMIDIATA; ICACINACEAE; RATTUS;

EID: 79959970974     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2011.04.009     Document Type: Article

References (22)

1. S. Apers, M. Claeys, T.E. De Bruyne, A.J. Vlietinck, and L. Pieters New acylated triterpenoid saponins from Maesa lanceolata Phytochemistry 52 1999 1121 1131 (Pubitemid 30016476)
2. S. Apers, S. Baronikova, J.B. Sindambiwe, M. Witvrouw, E. De Clercq, D. Vanden Berghe, E. Van Marck, A. Vlietinck, and L. Pieters Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships Planta Med. 67 2001 528 532 (Pubitemid 32800418)
3. S. Apers, G. Everaert, B.J. Van der Veken, A.J. Vlietinck, and L.A.C. Pieters Electronic structure calculations as a tool for investigating acyl migrations in ester saponins Phytochem. Anal. 13 2002 262 265
4. S. Apers, D. Paper, J. Bürgermeister, S. Baronikova, S. Van Dyck, G. Lemire, L. Pieters, and A. Vlietinck Antiangiogenic activity of synthetic dihydrobenzofuran lignans J. Nat. Prod. 65 2002 718 720 (Pubitemid 34547416)
5. S. Baróniková, S. Apers, D. Vanden Berghe, P. Cos, P. Vermeulen, A. Van Daele, L. Pieters, E. Van Marck, and A. Vlietinck An ex-vivo aniogenesis assay as a screening method for natural compounds and herbal drug preparations Planta Med. 70 2004 887 892 (Pubitemid 39457795)
6. T.D. Brackenbury, C.C. Appleton, and G. Thurman Mammal toxicity assessment of the plant molluscicide, Apodytes dimidiata (Icacinaceae), in South Africa Acta Trop. 65 1997 155 162
7. T.D. Brackenbury, and C.C. Appleton Acute toxicity evaluation of the plant molluscicide, Apodytes dimidiata (Icacinaceae), to Eisenia fetida (oligochaeta) and Oreochromis mossambicus (Cichlidae) in South Africa Acta Trop. 63 1997 1 14 (Pubitemid 27121672)
8. T.D. Brackenbury The molluscicidal properties of Apodytes dimidiata (Icacinaceae): geographical variation in molluscicidal potency Ann. Trop. Med. Parasitol. 93 1999 511 518 (Pubitemid 29385232)
9. Bryant, A.T., 1966. Zulu medicine and medicine-men. C. Struik. Cape Town.
10. P. Cos, A.J. Vlietinck, D. Vanden Berghe, and L. Maes Anti-infective potential of natural products: how to develop a stronger in vitro proof-of-concept J. Ethnopharmacol. 106 2006 290 302 (Pubitemid 43949328)
11. S.E. Drewes, and L. Kayonga Iridoid molluscicidal compounds from Apodytes dimidiata J. Nat. Prod. 59 1996 1169 1170 (Pubitemid 27026582)
12. G. Gaidi, T. Miyamoto, A. Rustaiyan, and MA. Lacaille-Dubois Three new acylated triterpene saponins from Acantophyllum squarrosum J. Nat. Prod. 64 2001 920 924 (Pubitemid 32729905)
13. J. Gestner A prelimenary checklist of Zulu names of plants with short notes Bantu Studies 12 215-236 1938 321 342
14. Hutchings, A., Scott, A.H., Lewis, G., Cunningham, A.B., 1996. Zulu Medicinal Plants: an Inventory. University of Natal Press, Pietermaritzburg.
15. Maes, L., 2003. Lead identification and development of a new anti-leishmanial saponin PX-6518, isolated from the Vietnamese plant Maesa balansae. Ph.D. Thesis. University of Antwerp, Antwerp.
16. L. Maes, D. Vanden Berghe, N. Germonprez, L. Quirijnen, P. Cos, N. De Kimpe, and L. Van Puyvelde In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral Leishmania species Antimicrob Agents Chemother. 48 2004 130 136a
17. P.M. Medeiros, and B.R.T. Simoneit Analysis of sugars in environmental samples by gas chromatography-mass spectrometry J. Chromatogr. A 1141 2007 271 278 (Pubitemid 46096968)
18. S.J. Pretorius, P.H. Joubert, A.H. Scott, and T.G. Fourie The molluscicidal properties of Apodytes dimidiata subsp. Dimidiata (Icacinaceae) J. Trop. Med. Hyg. 94 1991 159 165
19. Sleumer, H., 1971. Flora Malesiana: Series I. 7, 48-49.
20. N. Tan, J. Zhou, and S. Zhao Advances in structural elucidation of glucuronide oleanane-type triterpene carboxylic acid 3,28-O-bisdesmosides (1962-1997) Phytochemistry. 52 1999 153 192 (Pubitemid 29426483)
21. Vermeersch, M., Foubert, K., Inoecêncio da Luz, R., Van Puyvelde, L., Pieters, L., Cos, P., Maes, L., 2009. Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae. Phytother. Res. 23, 1404-1410.
22. J.M. Watt, and M.G. Breyer-Brandwijk The Medicinal and Poisonous Plants of Southern and Eastern Africa second ed. 1962 Livingstone Edinburgh