Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics

Psychopharmacology

Volumn 216, Issue 1, 2011, Pages 9-16

  Yang, Fu De ^a   Wang, Xiang Qun ^a   Liu, Xiu Ping ^a   Zhao, Ke Xin ^a   Fu, Wei Hong ^a   Hao, Xue Ru ^a   Zhang, Xing Li ^a   Huang, Guo Shu ^a   Qu, Sheng Cai ^a   Bai, Jing Shen ^a   Huang, Xu Feng ^b   Kosten, Thomas R ^c,d   Zhang, Xiang Yang ^c  

^a BEIJING HUILONGGUAN HOSPITAL   (China)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Antipsychotics; Electrocardiography; QT prolongation; Schizophrenia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; PERPHENAZINE; RISPERIDONE; SULPIRIDE;

ADULT; AGE; AGED; ARTICLE; CARDIOVASCULAR DISEASE; COMORBIDITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAPHY; FEMALE; GENDER; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PREVALENCE; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; SCHIZOPHRENIA; SEX DIFFERENCE;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HOSPITALS, PSYCHIATRIC; HUMANS; INSTITUTIONALIZATION; LONG QT SYNDROME; MALE; MIDDLE AGED; PREVALENCE; REGRESSION ANALYSIS; SCHIZOPHRENIA; SEX CHARACTERISTICS; TIME FACTORS;

EID: 79959958729     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2188-5     Document Type: Article

References (37)

1. HC Bazett 1920 An analysis of the time-relations of electrocardiograms Heart 7 353 370
2. SA Chong A Mythily Lum HY Goh YH Chan 2003 Prolonged QTc intervals in medicated patients with schizophrenia Hum Psychopharmacol 18 647 649 14696025 10.1002/hup.540 (Pubitemid 38028792)
3. CU Correll AM Frederickson V Figen EJ Ginn-Scott RA Pantaleon Moya JM Kane P Manu 2009 The QTc interval and its dispersion in patients receiving two atypical antipsychotics Eur Arch Psychiatry Clin Neurosci 259 1 23 27 18574608 10.1007/s00406-008-0829-4
4. J Czekalla S Kollack-Walker CM Beasley Jr 2001 Cardiac safety parameters of olanzapine: comparison with other atypical and typical antipsychotics J Clin Psychiatry 62 Suppl 2 35 40 11232751 1:CAS:528:DC%2BD3MXhs1Skuro%3D (Pubitemid 32154140)
5. H Elming J Sonne HKF Lublin 2003 The importance of the QT interval: a review of the literature Acta Psychiatr Scand 107 96 101 12534434 10.1034/j.1600-0447.2003.00061.x 1:STN:280:DC%2BD3s%2FislKquw%3D%3D (Pubitemid 36164476)
6. RJ Flanagan 2008 Side effects of clozapine and some other psychoactive drugs Curr Drug Saf 3 2 115 122 18690989 10.2174/157488608784529251 1:CAS:528:DC%2BD1MXjs1Wjtbk%3D
7. AH Glassman JT Bigger Jr 2001 Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death Am J Psychiatry 158 11 1774 1782 11691681 10.1176/appi.ajp.158.11.1774 1:STN:280:DC%2BD3MnktVentQ%3D%3D (Pubitemid 33054769)
8. PM Haddad IM Anderson 2002 Antipsychotic-related QTc prolongation, torsade de pointes and sudden death Drugs 62 11 1649 1671 12109926 10.2165/00003495-200262110-00006 1:CAS:528:DC%2BD38Xms1ahsbo%3D (Pubitemid 34848372)
9. EP Harrigan JJ Miceli R Anziano E Watsky KR Reeves NR Cutler J Sramek T Shiovitz M Middle 2004 A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition J Clin Psychopharmacol 24 1 62 69 14709949 10.1097/01.jcp.0000104913.75206.62 1:CAS:528:DC%2BD2cXhtlCmuw%3D%3D (Pubitemid 38134167)
10. UG Kang JS Kwon YM Ahn SJ Chung JH Ha YJ Koo YS Kim 2000 Electrocardiographic abnormalities in patients treated with clozapine J Clin Psychiatry 61 6 441 446 10901343 10.4088/JCP.v61n0609 1:CAS:528: DC%2BD3cXltFOnsL4%3D (Pubitemid 30452212)
11. SP Khan S Dahlvani WVR Vieweg 1998 Electrocardiographic QT interval in a geropsychiatric inpatient population: a preliminary study Med Psychiatr 1 71 74
12. CH Lin MC Chen SY Wang CY Lin 2004 Predictive factors for QTc prolongation in schizophrenic patients taking antipsychotics J Formos Med Assoc 103 6 437 441 15278188
13. P Mackin AH Young 2005 QTc interval measurement and metabolic parameters in psychiatric patients taking typical or atypical antipsychotic drugs: a preliminary study J Clin Psychiatry 66 11 1386 1391 16420075 10.4088/JCP.v66n1107 1:CAS:528:DC%2BD2MXhtlamsb7N (Pubitemid 41779536)
14. DB Merrill GW Dec DC Goff 2005 Adverse cardiac effects associated with clozapine J Clin Psychopharmacol 25 1 32 41 15643098 10.1097/01.jcp.0000150217. 51433.9f 1:CAS:528:DC%2BD2MXisVSisw%3D%3D (Pubitemid 40129380)
15. Y Ozeki K Fujii N Kurimoto N Yamada M Okawa T Aoki J Takahashi N Ishida M Horie H Kunugi 2010 QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 34 2 401 405 20079791 10.1016/j.pnpbp.2010.01.008 1:CAS:528:DC%2BC3cXit1antrY%3D
16. JS Perkiömäki MJ Koistinen S Yli-Mäyry HV Huikuri 1995 Dispersion of the QT interval in patients with and without susceptibility to ventricular tachyarrhythmias after previous myocardial infarction J Am Coll Cardiol 26 174 179 7797747 10.1016/0735-1097(95)00122-G
17. R Ramos-Ríos M Arrojo-Romero E Paz-Silva F Carballal-Calvo JL Bouzón-Barreiro J Seoane-Prado R Codesido-Barcala A Crespí- Armenteros R Fernández-Pérez JD López-Moríñigo I Tortajada-Bonaselt FJ Diaz J de Leon 2010 QTc interval in a sample of long-term schizophrenia inpatients Schizophr Res 116 1 35 43 19892525 10.1016/j.schres.2009.09.041
18. PM Rautaharju SH Zhou S Wong HP Calhoun GS Berenson R Prineas, et al. 1992 Sex differences in the evolution of the electrocardiographic QT interval with age Can J Cardiol 8 7 690 695 1422988 1:STN:280:DyaK3s%2FksFOgtA%3D%3D
19. JG Reilly SA Ayis IN Ferrier SJ Jones SH Thomas 2000 QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients Lancet 355 9209 1048 1052 10744090 10.1016/S0140-6736(00)02035-3 1:CAS:528: DC%2BD3cXisFOnsb8%3D (Pubitemid 30162807)
20. MA Rettenbacher U Eder-Ischia A Bader M Edlinger A Hofer M Hummer G Kemmler EM Weiss M Hochleitner WW Fleischhacker 2005 QTc variability in schizophrenia patients treated with antipsychotics and healthy controls J Clin Psychopharmacol 25 3 206 210 15876897 10.1097/01.jcp.0000162799.64378.fc (Pubitemid 40685782)
21. M Sala A Vicentini P Brambilla C Montomoli JR Jogia E Caverzasi A Bonzano M Piccinelli F Barale GM De Ferrari 2005 QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy Ann Gen Psychiatry 4 1 1 15845138 10.1186/1744-859X-4-1 (Pubitemid 40854389)
22. C Stöllberger JO Huber J Finsterer 2005 Antipsychotic drugs and QT prolongation Int Clin Psychopharmacol 20 5 243 251 16096514 10.1097/01.yic. 0000166405.49473.70 (Pubitemid 41192144)
23. M Stramba-Badiale D Spagnolo G Bosi PJ Schwartz 1992 Are gender differences in QTc present at birth? MISNES investigators. Multicenter Italian study on neonatal electrocardiography and sudden infant death syndrome Am J Cardiol 75 17 1277 1278
24. M Stramba-Badiale EH Locati A Martinelli J Courville PJ Schwartz 1997 Gender and the relationship between ventricular repolarisation and cardiac cycle length during 24-hour Holter recordings Eur Heart J 18 1000 1006 9183593 1:STN:280:DyaK2szis1OksA%3D%3D (Pubitemid 27230673)
25. JC Sumić V Barić P Bilić M Herceg M Sisek-Sprem V Jukić 2007 QTc and psychopharmacs: are there any differences between monotherapy and polytherapy Ann Gen Psychiatry 6 13 17477877 10.1186/1744-859X-6-13 (Pubitemid 46813766)
26. D Taylor 2003 Ziprasidone in the management of schizophrenia : the QT interval issue in context CNS Drugs 17 6 423 430 12697001 10.2165/00023210- 200317060-00004 1:CAS:528:DC%2BD3sXksVahu7c%3D (Pubitemid 36560704)
27. C van Noord SM Straus MC Sturkenboom A Hofman AJ Aarnoudse V Bagnardi JA Kors C Newton-Cheh JC Witteman BH Stricker 2009 Psychotropic drugs associated with corrected QT interval prolongation J Clin Psychopharmacol 29 1 9 15 19142100 10.1097/JCP.0b013e318191c6a8
28. C van Noord M Dörr MC Sturkenboom SM Straus T Reffelmann SB Felix A Hofman JA Kors R Haring FH de Jong M Nauck AG Uitterlinden H Wallaschofski JC Witteman H Völzke BH Stricker 2010 The association of serum testosterone levels and ventricular repolarization Eur J Epidemiol 25 1 21 28 19957021 10.1007/s10654-009-9406-z 1:CAS:528:DC%2BC3cXnt1agsw%3D%3D
29. WVR Vieweg 2002 Mechanisms and risk of electrocardiographic QT interval prolongation when using antipsychotic drugs J Clin Psychiatry 63 suppl 9 18 24 12088172 1:CAS:528:DC%2BD38XltlKrt7w%3D
30. WV Vieweg 2003 New generation antipsychotic drugs and QTc interval prolongation Prim Care Companion J Clin Psychiat 5 205 215 10.4088/PCC.v05n0504
31. WV Vieweg MA Wood A Fernandez M Beatty-Brooks M Hasnain AK Pandurangi 2009 Proarrhythmic risk with antipsychotic and antidepressant drugs. Implications in the elderly Drugs Aging 26 997 1012 19929028 10.2165/11318880-000000000-00000 1:CAS:528:DC%2BC3cXpvFyguw%3D%3D
32. B Warner P Hoffmann 2002 Investigation of the potential of clozapine to cause torsade de pointes Adverse Drug React Toxicol Rev 21 4 189 203 12503253 1:CAS:528:DC%2BD3sXpsVyr (Pubitemid 36018766)
33. JP Warner TR Barnes JA Henry 1996 Electrocardiographic changes in patients receiving neuroleptic medication Acta Psychiatr Scand 93 311 313 8712033 10.1111/j.1600-0447.1996.tb10653.x 1:STN:280:DyaK28zltVKmtw%3D%3D (Pubitemid 26148719)
34. XH Wehrens 2006 Structural determinants of potassium channel blockade and drug-induced arrhythmias Handb Exp Pharmacol 171 123 157 16610343 10.1007/3-540-29715-4-5 1:CAS:528:DC%2BD2MXhtlCjurbL
35. SW Woods 2003 Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 64 663 667 12823080 10.4088/JCP.v64n0607 1:CAS:528:DC%2BD3sXls12ktb0%3D (Pubitemid 36750143)
36. AE Yagcioglu BB Akdede TI Turgut 2005 A doubleblind controlled study of adjunctive treatment with risperidone in schizophrenic patients partially responsive to clozapine: efficacy and safety J Clin Psychiatry 66 63 72 10.4088/JCP.v66n0109 1:CAS:528:DC%2BD2MXhsV2htLo%3D
37. WR Zemrak GA Kenna 2008 Association of antipsychotic and antidepressant drugs with Q-T interval prolongation Am J Health-Syst Pharm 65 11 1029 1038 18499875 10.2146/ajhp070279 1:CAS:528:DC%2BD1cXnsFGitbc%3D (Pubitemid 351768736)