Electrocardiographic abnormalities in patients treated with clozapine

Journal of Clinical Psychiatry

Volumn 61, Issue 6, 2000, Pages 441-446

  Kang, Ung Gu ^a   Kwon, Jun Soo ^a   Ahn, Yong Min ^a   Chung, Sun Ju ^b   Ha, Jee Hyun ^a   Koo, Young Jin ^a   Kim, Yong Sik ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Gachon University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; DRUG EFFECT; DRUG SCREENING; ELECTROCARDIOGRAM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; SCHIZOPHRENIA; TREATMENT OUTCOME;

EID: 0343953054     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v61n0609     Document Type: Article

References (26)

1. Liberman JA, Alvir JMJ. A report of clozapine induced agranulocytosis in the United States: incidence and risk factors. Drug Saf 1992;7(suppl 1): 1-2
2. Honigfeld G. Effects of the clozapine national registry system on incidence of deaths related to agranulocytosis. Psychiatr Serv 1996;47:52-56
3. Ennis LM, Parker RM. Paradoxical hypertension associated with clozapine [letter]. Med J Aust 1997;166:278
4. George TP, Winther LC. Hypertension after initiation of clozapine. Am J Psychiatry 1996;153:1368-1369
5. Shiwach RS. Treatment of clozapine induced hypertension and possible mechanisms. Clin Neuropharmacol 1998;21:139-140
6. Khalil N. Peri-/Myokarditis unter Clozapin (Leponex). Psychiatr Prax 1997;24:46
7. Bandelow B, Degner D, Kreusch U, et al. Myocarditis under therapy with clozapine. Schizophr Res 1995;17:293-294
8. Leo RJ, Kreeger JL, Kim KY. Cardiomyopathy associated with clozapine. Ann Pharmacother 1996;30:603-605
9. Ketch J, Herd A, Ludwig L. ST segment elevations without myocardial infarction in a patient on clozapine [letter]. Am J Emerg Med 1996;14: 111-112
10. Beale MD, Pritchett JT, Kellner CH. Supraventricular tachycardia in a patient receiving ECT, clozapine, and caffeine. Convuls Ther 1994;10: 228-231
11. Desta Z, Kerbusch T, Flockhart DA. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). Clin Pharmacol Ther 1999;65:10-20
12. Tueth MJ, Cheong JA. Clinical uses of pimozide. South Med J 1993;86: 344-349
13. Schmidt W, Lang K. Life-threatening dysrhythmias in severe thioridazine poisoning treated with physostigmine and transient atrial pacing. Crit Care Med 1997;25:1925-1930
14. Roden DM. Torsade de pointes. Clin Cardiol 1993;16:683-686
15. Liberatore MA, Robinson DS. Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy? J Clin Psychopharmacol 1984;4:143-146
16. Brown GR, Radford JM. Sertindole hydrochloride: a novel antipsychotic medication with a favorable side effect profile. South Med J 1997;90: 691-693
17. Chouinard G, Annable L, Melancon, et al. Chlorpromazine-induced electrocardiogram abnormalities. Int J Clin Pharmacol Biopharm 1975;11: 327-331
18. Bolognesi R, Tsialtas D, Vasini P, et al. Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. Am J Cardiol 1997;79:242-245
19. Ebert SN, Liu XK, Woosley RL. Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence. J Womens Health 1998;7:547-557
20. Warner JP, Barnes TR, Henry JA. Electrocardiographic changes in patients receiving neuroleptic medication. Acta Psychiatr Scand 1996;93:311-313
21. Sramek JJ, Cutler NR, Kurtz NM, et al. Optimizing the Development of Antipsychotic Drugs. Chichester, England: John Wiley & Sons; 1997: 53-99
22. Stahl SM. Psychopharmacology of Antipsychotics. London. England: Martin Dunitz Ltd; 1999
23. Jackson T, Ditmanson L, Phibbs B. Torsade de pointes and low-dose oral haloperidol. Arch Intern Med 1997;157:2013-2015
24. Fei L, Statters DJ, Anderson MH, et al. Is there an abnormal QT interval in sudden cardiac death survivors with a "normal" QTc? Am Heart J 1994; 128:73-76
25. Funck-Brentano C, Jaillon P. Rate-corrected QT interval: techniques and limitations. Am J Cardiol 1993;72:17B-22B
26. Stoletniy LN, Pai SM, Platt ML, et al. QT dispersion as a noninvasive predictor of inducible ventricular tachycardia. J Electrocardiol 1999;32: 173-177